CAREER: Nucleophilic, Radical, and Electrophilic Palladium Carbene Complexes: New Types of Reactivity For Palladium
职业:亲核、自由基和亲电钯卡宾配合物:钯的新型反应性
基本信息
- 批准号:1552397
- 负责人:
- 金额:$ 60.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-01 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this CAREER project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Vlad M. Iluc of the Department of Chemistry at the University of Notre Dame is developing new tools for the selective reaction of hydrogen atoms bonded to common elements such as carbon, oxygen, boron, nitrogen and silicon. In this project, new approaches that involve metal-ligand cooperation are being developed to facilitate chemical transformations under mild conditions. This work is expected to have environmental and societal impact by providing basic knowledge that allows the development of catalytic processes involving water, alcohol, and amines, which are readily available chemical feedstocks. As the educational component of his project, Professor Iluc is developing an outreach program that focuses on mentoring of students from socio-economic groups that are underrepresented in science. The educational program provides educational opportunities for youth at the Bashor Children's Home and promotes their recruitment into science, technology, engineering and mathematics-based careers.The project targets (1) hydrogen transfer from the ligand to the metal and vice versa, which involves a nucleophilic carbene as part of a diphosphine pincer ligand; (2) hemilabile ligands, which incorporate olefins in a pincer architecture, in order to synthesize new untethered carbene nickel and palladium complexes; and (3) transfer of radical character from the supporting ligand to a coordinated substrate. The first class of complexes features nucleophilic carbene palladium complexes that are applied to the hydration, hydroalkoxylation, and hydroamination of olefins and other unsaturated substrates. The second class focuses on nickel and palladium and is applied to carbon (C)- silicon (Si) and C- boron (B) bond forming reactions. Finally, the third class features radical carbene palladium complexes that are applied to C-hydrogen (H) amination reactions with azides and olefin copolymerization reactions. Molecular models based on density functional theory guide these experiments. The educational project includes collaboration with the Bashor Children's Home, in Goshen, Indiana, a non-profit agency that provides help for at-risk children. In addition, the CAREER Award supports summer research activities at the University of Notre Dame. Visiting high school students work closely with graduate and undergraduate chemistry students in science activities related to research in the Iluc group.
在这个由化学系化学催化计划资助的职业项目中,圣母大学化学系的Vlad M.ILUC教授正在开发新的工具,用于与碳、氧、硼、氮和硅等常见元素键合的氢原子的选择性反应。在这个项目中,正在开发涉及金属-配体合作的新方法,以促进在温和条件下的化学转化。这项工作预计将对环境和社会产生影响,因为它提供了允许开发涉及水、酒精和胺的催化过程的基本知识,这些都是容易获得的化学原料。作为他项目的教育组成部分,ILUC教授正在开发一项外展计划,重点是指导那些在科学领域代表性不足的社会经济群体的学生。该教育计划为Bashor儿童之家的年轻人提供教育机会,并促进他们进入科学、技术、工程和基于数学的职业。该项目的目标是(1)氢从配体到金属的转移,反之亦然,这涉及到亲核卡宾作为双膦钳形配体的一部分;(2)半碱基配体,它将烯烃结合在钳形结构中,以合成新的自由卡宾镍和钯配合物;以及(3)将自由基性质从支持配体转移到配位底物。第一类配合物的特点是亲核的卡宾钯配合物,用于烯烃和其他不饱和底物的水合、氢烷氧基化和氢胺化。第二类是镍和钯,用于碳(C)-硅(Si)和碳-硼(B)键的形成反应。最后,第三类以自由基卡宾钯配合物为特征,用于叠氮化合物的C-氢(H)胺化反应和烯烃共聚反应。基于密度泛函理论的分子模型指导着这些实验。该教育项目包括与印第安纳州戈申的Bashor儿童之家合作,这是一家为高危儿童提供帮助的非营利性机构。此外,职业奖还支持圣母大学的暑期研究活动。来访的高中生与化学专业的研究生和本科生密切合作,开展与ILUC小组研究相关的科学活动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Vlad Iluc其他文献
Vlad Iluc的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Vlad Iluc', 18)}}的其他基金
CAS:Toward Iron Olefin Metathesis: Synthesis and Reactivity of Iron Carbenes
CAS:铁烯烃复分解:铁卡宾的合成和反应性
- 批准号:
2102517 - 财政年份:2021
- 资助金额:
$ 60.33万 - 项目类别:
Standard Grant
相似海外基金
CAREER: Nucleophilic Cobalt Photocatalysis for the Generation of Radicals from Non-Traditional Precursors
职业:亲核钴光催化从非传统前体产生自由基
- 批准号:
2338732 - 财政年份:2024
- 资助金额:
$ 60.33万 - 项目类别:
Continuing Grant
Development of Strongly Lewis Acidic and Nucleophilic Boron Reagents and Its Catalytic Reactions
强路易斯酸性亲核硼试剂的研制及其催化反应
- 批准号:
23K06048 - 财政年份:2023
- 资助金额:
$ 60.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Nucleophilic amination with an azanide surrogate
与氮氧化物替代物的亲核胺化
- 批准号:
2905473 - 财政年份:2023
- 资助金额:
$ 60.33万 - 项目类别:
Studentship
Nucleophilic aromatic substitution on electron-rich aniline derivatives via transient polarity inversion with N-centered radical (cationic) substituents
通过 N 中心自由基(阳离子)取代基的瞬时极性反转对富电子苯胺衍生物进行亲核芳香取代
- 批准号:
527488163 - 财政年份:2023
- 资助金额:
$ 60.33万 - 项目类别:
WBP Fellowship
Metal-Catalyzed Nucleophilic Substitution Reactions of Alkyl Electrophiles
金属催化烷基亲电试剂的亲核取代反应
- 批准号:
10625376 - 财政年份:2022
- 资助金额:
$ 60.33万 - 项目类别:
Addressing Sustainability Concerns of Nucleophilic Cyanation using Disubstituted Malononitriles as Electrophilic Nitrilation Reagents
使用二取代丙二腈作为亲电硝化试剂解决亲核氰化的可持续性问题
- 批准号:
568891-2022 - 财政年份:2022
- 资助金额:
$ 60.33万 - 项目类别:
Postgraduate Scholarships - Doctoral
Harnessing Carbonyls As Nucleophilic Handles Via C-C Cleavage
通过 C-C 裂解利用羰基作为亲核手柄
- 批准号:
577680-2022 - 财政年份:2022
- 资助金额:
$ 60.33万 - 项目类别:
Canadian Graduate Scholarships Foreign Study Supplements
Metal-Catalyzed Nucleophilic Substitution Reactions of Alkyl Electrophiles
金属催化烷基亲电试剂的亲核取代反应
- 批准号:
10810179 - 财政年份:2022
- 资助金额:
$ 60.33万 - 项目类别:
Metal-Catalyzed Nucleophilic Substitution Reactions of Alkyl Electrophiles
金属催化烷基亲电试剂的亲核取代反应
- 批准号:
10406704 - 财政年份:2022
- 资助金额:
$ 60.33万 - 项目类别:
Synthesis of enolates by nucleophilic substitution
通过亲核取代合成烯醇化物
- 批准号:
EP/W012626/1 - 财政年份:2022
- 资助金额:
$ 60.33万 - 项目类别:
Research Grant