CAS:Toward Iron Olefin Metathesis: Synthesis and Reactivity of Iron Carbenes

CAS：铁烯烃复分解：铁卡宾的合成和反应性

• 批准号: 2102517
• 负责人: Vlad Iluc
• 金额: $ 47.5万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2102517&HistoricalAwards=false
• 关键词: CAS; Toward; Iron; Olefin; Metathesis

With the support of the Chemical Catalysis program in the Division of Chemistry, Vlad M. Iluc of Notre Dame University will study an important chemical transformation known olefin metathesis, using earth-abundant transition metal catalysts. The olefin metathesis reaction positively impacts numerous fields in academic research and industry, ranging from synthesis of value-added compounds to applications in materials science and biology. Catalysts currently employed utilize rather costly transition metals such as ruthenium. The proposed research seeks to fundamentally change this approach and could have a significant component of sustainable chemistry as an effective olefin metathesis reaction based upon an earth-abundant metal such as iron would reduce dependence on precious and toxic metals. Dr. Iluc and his team will integrate their scientific activities and results with the Center for Sustainable Energy at Notre Dame (ND Energy) and share their discoveries with the broader research community. The Iluc research group will work to enhance diversity in science by attracting women and underrepresented minorities to work on the proposed projects. The PI and several group members will continue their in person mentorship of teenagers at the Bashor Children’s Home, a non-profit child welfare agency that provides assistance to troubled children and their families through residential care, and help with alternative education and other activities.Vlad M. Iluc and his team at the University of Notre Dame will work to develop an alternative manifold for olefin metathesis based upon earth-abundant metal catalysts. Olefin metathesis reactions are well known for ruthenium catalysis, but those that utilize iron are only now being discovered. Recent workroom the Iluc group demonstrating that iron carbenes can mediate olefin metathesis reactions similar to ruthenium lay the foundation for the proposed work. The results from this project will likely provide foundational insight to guide future developments in iron olefin metathesis catalysis. In this project, Dr. Iluc and his coworkers will investigate the electronic structures and chemical reactivity of tethered iron carbene complexes and apply this knowledge to the synthesis and isolation of mono-tethered and untethered analogues for new catalytic applications. This research program is designed to increase broader participation in STEM through team-coordinated outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学催化项目的支持下，圣母大学的Vlad M.ILUC将利用富含稀土的过渡金属催化剂，研究一种重要的化学转化，即烯烃歧化反应。从增值化合物的合成到材料科学和生物学的应用，烯烃歧化反应对学术研究和工业中的许多领域都产生了积极的影响。目前使用的催化剂使用相当昂贵的过渡金属，如Ru。拟议的研究试图从根本上改变这种方法，并可能在可持续化学中具有重要组成部分，因为基于富含地球的金属(如铁)的有效烯烃化合反应将减少对贵金属和有毒金属的依赖。ILUC博士和他的团队将把他们的科学活动和成果与圣母大学可持续能源中心(ND Energy)整合起来，并与更广泛的研究社区分享他们的发现。国际劳工联合会研究小组将通过吸引妇女和代表不足的少数群体参与拟议的项目，努力加强科学的多样性。PI和几名小组成员将继续在Bashor儿童之家亲自指导青少年，Bashor儿童之家是一家非营利性儿童福利机构，通过寄宿照顾为问题儿童及其家庭提供帮助，并帮助替代教育和其他活动。圣母大学的Vlad M.ILUC和他的团队将致力于开发一种基于地球上丰富的金属催化剂的烯烃化合反应替代歧管。烯烃歧化反应是众所周知的Ru催化反应，但那些利用铁的反应直到现在才被发现。最近的工作室，ILUC小组展示了铁卡宾可以介导类似于Ru的烯烃歧化反应，为拟议的工作奠定了基础。该项目的研究结果将为指导铁烯复分解催化剂的未来发展提供基础性的见解。在这个项目中，ILUC博士和他的同事们将研究卡宾铁络合物的电子结构和化学反应活性，并将这些知识应用于合成和分离单链和非链状类似物，以用于新的催化应用。这一研究计划旨在通过团队协调的外展活动增加对STEM的更广泛参与。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。