CAREER: Chemical Transformations Enabled by Flow Chemistry

职业：流动化学实现化学转化

• 批准号: 1555300
• 负责人: Aaron Beeler
• 金额: $ 61.42万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1555300&HistoricalAwards=false
• 关键词: CAREER; Chemical; Transformations; Enabled; Flow

In this CAREER project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Beeler of the Department of Chemistry at Boston University is developing new chemical methods utilizing flow chemistry. Traditionally, chemical transformations have been carried out in batch reactors such as flasks and beakers. Instead, the Beeler lab carries out reactions by continuously flowing reagents inside of tubing. This approach may lead to significantly more efficient methods for synthesizing molecules with applications in human health, materials science, and agriculture. The Beeler lab is involved in efforts to bring science education to high school students in the Boston area. This award supports the development of outreach activities including a science summer camp for local high school students.The research projects focus on three reaction classes that are significantly enabled by flow chemistry. Photochemistry may be considered one of the most powerful complexity-generating reaction classes available to chemists. When utilizing a flow chemistry platform, it may be possible to overcome issues inherent to batch photochemical reactions, such as long reaction times, poor reproducibility, and difficult scalability. This aspect of the project explores a number of powerful photochemical reactions such as [2+2]-photocycloaddition, reactions of photoinduced phenyl cations, and photoinduced electron transfer reactions. Electrochemical reactions are often underutilized and can be difficult to optimize and scale. This project develops a practical and scalable electrochemical flow platform that is utilized in the development of oxidative coupling of phenols. Many examples of flow chemistry utilize highly toxic and/or reactive species or reactions under extreme conditions. This project focuses on generating and utilizing highly reactive diazoalkanes in complexity-generating reactions. In addition to this research, the educational outreach focuses on developing a science summer camp at the high school level for students from disadvantaged backgrounds. New laboratory experiments are being developed to introduce flow chemistry into the undergraduate organic chemistry laboratory curriculum at Boston University.

在这个由化学系化学合成项目资助的CAREER项目中，波士顿大学化学系的Beeler教授正在利用流动化学开发新的化学方法。传统上，化学转化是在诸如烧瓶和烧杯之类的间歇反应器中进行的。相反，比勒实验室通过在管道内不断流动的试剂来进行反应。这种方法可能会导致更有效的合成分子的方法，并在人类健康、材料科学和农业中得到应用。比勒实验室致力于将科学教育带给波士顿地区的高中生。该奖项支持拓展活动的发展，包括为当地高中生举办的科学夏令营。研究项目集中在三种反应类别上，这三种反应类别都是由流动化学显著促成的。光化学可以被认为是化学家所能得到的最强大的产生复杂性的反应类之一。当利用流动化学平台时，有可能克服批处理光化学反应固有的问题，如反应时间长、重现性差和难以扩展。这方面的项目探索了一些强大的光化学反应，如[2+2]-光环加成反应，光诱导苯基阳离子反应和光诱导电子转移反应。电化学反应通常未被充分利用，并且难以优化和规模化。本项目开发了一个实用且可扩展的电化学流动平台，用于酚类氧化偶联的开发。流动化学的许多例子在极端条件下使用剧毒和/或反应性物质或反应。这个项目的重点是在复杂生成反应中生成和利用高活性的重氮烷烃。除本研究外，教育推广的重点是为来自弱势背景的学生开发高中水平的科学夏令营。波士顿大学正在开发新的实验室实验，以将流动化学引入本科有机化学实验室课程。