I-Corps Teams: Membrane Adsorbers for Biologics Purification
I-Corps 团队:用于生物制品纯化的膜吸附器
基本信息
- 批准号:1556563
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-01 至 2017-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Rising rates of chronic conditions such as cancer and cardiovascular diseases are driving the demand for biologic drugs used to treat them. Currently, there are over 130 biologics approved for use in the US, with a market exceeding $140 B. Over 900 new biologics targeting more than 100 diseases are under development. New product commercialization will require significant expansions in production capacity and improvements in manufacturing flexibility to meet future market demands. In addition, the emergence of biosimilars, biobetters, and increasing competition will apply economic pressure on biomanufacturers to innovate new drug manufacturing technologies to lower production costs. Innovations are especially needed in downstream drug purification, which often limits the production capacity and contributes 30-40% of the overall manufacturing cost. This I-Corps team is developing a platform (PuriTM membranes) to dramatically enhance production capacity and flexibility in the downstream purification of biologic drugs. The disposable nature of the PuriTM platform is expected to reduce biomanufacturing production costs significantly.This project is expected to accelerate market entry of PuriTM membrane innovations by developing the entrepreneurial knowledge and skills of the I-Corps team that are needed to translate the innovation from the academic laboratory to the industry sector. PuriTM adsorptive membrane modules are single-use membrane products that purify biologic drugs. They are characterized by high drug binding capacity, high selectivity, and high tolerance to feedstock conditions. Laboratory research has demonstrated that the firstgeneration PuriTM membranes specifically address all of the known customer pain points. Through customer interviews and use of the business model canvas, the team will test the proposition that these single-use adsorptive membrane innovations will derive commercial value from their abilities to increase the production capacity and flexibility of biomanufacturing facilities and lower the manufacturing cost of biologics. Identification of early acceptance customers also is expected as an outcome of the project. The team will develop alpha prototypes and work closely with potential customers on external validation of these prototypes. Completion of external validation will provide additional opportunities for the team to understand customer needs and test assumptions about the product utility and design. It also will provide vital data to attract external investors and new customers. A validated business plan and minimum viable products areexpected at the end of the I-Corps program.
癌症和心血管疾病等慢性疾病的发病率不断上升,推动了对用于治疗这些疾病的生物药物的需求。目前,美国批准使用的生物制剂超过130种,市场规模超过140亿美元,针对100多种疾病的900多种新生物制剂正在开发中。新产品商业化将需要大幅度扩大生产能力和提高制造灵活性,以满足未来的市场需求。此外,生物仿制药、生物改良药的出现和日益激烈的竞争将对生物制药商施加经济压力,迫使他们创新新的药物制造技术,以降低生产成本。下游药物纯化尤其需要创新,这往往限制了生产能力,并占总制造成本的30-40%。I-Corps团队正在开发一个平台(PuriTM膜),以显著提高生物药物下游纯化的生产能力和灵活性。清教徒平台的一次性特性有望显著降低生物制造的生产成本。该项目预计将通过培养I-Corps团队的创业知识和技能来加速清教徒膜创新的市场进入,这些知识和技能是将学术实验室的创新转化为工业部门所需要的。清教徒吸附膜组件是一次性使用的膜产品,净化生物药物。它们的特点是高药物结合能力,高选择性和对原料条件的高耐受性。实验室研究表明,第一代清透膜专门解决所有已知的客户痛点。通过客户访谈和商业模式画布的使用,该团队将测试这些一次性吸附膜创新将从其提高生物制造设施的生产能力和灵活性以及降低生物制剂制造成本的能力中获得商业价值的主张。早期验收客户的识别也被期望作为项目的结果。该团队将开发alpha原型,并与潜在客户密切合作,对这些原型进行外部验证。外部验证的完成将为团队提供更多的机会来了解客户需求,并测试关于产品效用和设计的假设。它还将为吸引外部投资者和新客户提供重要数据。在I-Corps项目结束时,预计将有一个经过验证的商业计划和最小可行产品。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Scott Husson其他文献
Scott Husson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Scott Husson', 18)}}的其他基金
PFI:AIR-TT: Translation of multimodal membrane adsorbers for protein purifications
PFI:AIR-TT:用于蛋白质纯化的多模式膜吸附器的转化
- 批准号:
1640645 - 财政年份:2016
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
UNS:High-performance membranes for engineered osmosis
UNS:用于工程渗透的高性能膜
- 批准号:
1510790 - 财政年份:2015
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Multimodal Membranes for High-throughput Bioseparations
用于高通量生物分离的多模式膜
- 批准号:
1159622 - 财政年份:2012
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
REU Site: Advanced Functional Membranes
REU 网站:高级功能膜
- 批准号:
1061524 - 财政年份:2011
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
GOALI: Understanding Plasticization and Compaction Mechanisms in Perfluorocyclobutyl Polymer Thin Films and Membranes
目标:了解全氟环丁基聚合物薄膜和膜的塑化和压实机制
- 批准号:
0966581 - 财政年份:2010
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Acquisition of an Atomic Force Microscope for Materials Research and Education
购买原子力显微镜用于材料研究和教育
- 批准号:
0315487 - 财政年份:2003
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
CAREER: Peptide Adsorption Dynamics on Molecularly Imprinted Surfaces: A Surface Plasmon Resonance Study
职业:分子印迹表面上的肽吸附动力学:表面等离子共振研究
- 批准号:
9983737 - 财政年份:2000
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
相似海外基金
How can we make use of one or more computationally powerful virtual robots, to create a hive mind network to better coordinate multi-robot teams?
我们如何利用一个或多个计算能力强大的虚拟机器人来创建蜂巢思维网络,以更好地协调多机器人团队?
- 批准号:
2594635 - 财政年份:2025
- 资助金额:
$ 5万 - 项目类别:
Studentship
Using Scholarships, Teams and Research to Engage Undergraduate STEM Students at an HSI
利用奖学金、团队和研究吸引 HSI 本科 STEM 学生
- 批准号:
2345369 - 财政年份:2024
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
A new model of teamwork for Human-Autonomy Teams (HATs)
人类自主团队 (HAT) 的新团队合作模式
- 批准号:
DP240101861 - 财政年份:2024
- 资助金额:
$ 5万 - 项目类别:
Discovery Projects
Conference: Supporting Mid-Scale Research Infrastructure Readiness for STEM Education Research Teams
会议:支持 STEM 教育研究团队的中型研究基础设施准备
- 批准号:
2412719 - 财政年份:2024
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Swarm construction: ant-inspired processes for teams of building robots
群体建造:建筑机器人团队的受蚂蚁启发的流程
- 批准号:
FT220100669 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
ARC Future Fellowships
Satisficing Trust in Human Robot Teams
满足人类机器人团队的信任
- 批准号:
EP/X028569/1 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Research Grant
Collaborative Research: Increasing Capabilities of Heterogeneous Robot Teams through Mutually Beneficial Physical Interactions
协作研究:通过互利的物理交互提高异构机器人团队的能力
- 批准号:
2308653 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Collaborative Research: Leveraging Crowd-AI Teams for Scalable Novelty Ratings of Heterogeneous Design Representations
协作研究:利用群体人工智能团队对异构设计表示进行可扩展的新颖性评级
- 批准号:
2231254 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Collaborative Research: Leveraging Crowd-AI Teams for Scalable Novelty Ratings of Heterogeneous Design Representations
协作研究:利用群体人工智能团队对异构设计表示进行可扩展的新颖性评级
- 批准号:
2231261 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
CAREER: Decentralized and Online Planning for Emergent Cooperation in Multi-Robot Teams
职业:多机器人团队紧急合作的去中心化在线规划
- 批准号:
2235622 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant