CSBR: Living Stocks - Enhancement of the Caenorhabditis Natural Diversity Resource
CSBR:活畜 - 增强秀丽隐杆线虫自然多样性资源
基本信息
- 批准号:1930382
- 负责人:
- 金额:$ 70.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Studies of conserved biological processes require model organisms which share attributes with humans. Most model organisms are easily grown in the laboratory and enable experimental manipulations. Over the last forty years, the nematode Caenorhabditis elegans has been instrumental in numerous fundamental advances in genetics, developmental biology, and neurobiology. However, all of these discoveries come from studies of a single strain in the species. This limitation is similar to the argument that we can understand all of human biology by the study of a single person in our species. This project seeks to expand the C. elegans Natural Diversity Resource (CeNDR), which comprises nearly 1000 genetically distinct strains from around the world. This genetic diversity facilitates discoveries about the evolution of physiological and behavioral traits, including responses to chemical and biotic stresses. Because humans share many of the same genes and processes as this nematode species, studies using this organism can teach us a great deal about how the human population differs.CeNDR has three major goals: (1) Collect, organize, and disseminate wild C. elegans strains; (2) Organize and disseminate whole-genome sequence and variant data for wild strains; and (3) Provide a genetics portal to facilitate mappings and interpretations of results. This project will address critical improvements to the methodology and technology of each of those goals. These improvements will enable future discoveries with CeNDR and will enable the planned expansion to include strains, whole-genome data, and mappings for two related nematode species: C. briggsae and C. tropicalis. This expansion to the Caenorhabditis Natural Diversity Resource (CaeNDR) will build unparalleled new capacity for comparative evolution approaches in nematodes and likely other organisms. Most research groups do not have the combination of experimental, computational, and statistical training to easily perform studies of natural variation. This project will make these tools available and usable by research laboratories across diverse model organism communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
对保守生物过程的研究需要与人类有共同属性的模型生物。大多数模型生物很容易在实验室中生长,并能够进行实验操作。在过去的40年里,线虫秀丽线虫在遗传学、发育生物学和神经生物学方面取得了许多基础进展。然而,所有这些发现都来自对该物种中单一菌株的研究。这一局限类似于这样一种观点,即我们可以通过研究我们物种中的一个人来理解所有人类生物学。该项目旨在扩大线虫自然多样性资源(CEDR),该资源由来自世界各地的近1000种不同的遗传菌株组成。这种遗传多样性有助于发现生理和行为特征的进化,包括对化学和生物胁迫的反应。由于人类与这种线虫物种共享许多相同的基因和过程,使用这种生物的研究可以教会我们许多关于人类种群的差异。CeNDR有三个主要目标:(1)收集、组织和传播野生线虫菌株;(2)组织和传播野生菌株的全基因组序列和变异数据;以及(3)提供一个遗传学门户网站,以便于绘制和解释结果。该项目将针对这些目标中每一项的方法和技术进行重大改进。这些改进将使未来能够发现cendr,并使计划中的扩展包括菌株、全基因组数据和两个相关线虫物种的映射:布氏线虫和热带线虫。这种对线虫自然多样性资源(CaeNDR)的扩展将在线虫和可能的其他生物中建立无与伦比的比较进化方法的新能力。大多数研究小组没有实验、计算和统计训练的组合,无法轻松地进行自然变异研究。该项目将使这些工具可供不同模式生物体社区的研究实验室使用。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluating the power and limitations of genome-wide association studies in Caenorhabditis elegans.
- DOI:10.1093/g3journal/jkac114
- 发表时间:2022-07-06
- 期刊:
- 影响因子:0
- 作者:
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Erik Andersen其他文献
A trace-based framework for analyzing and synthesizing educational progressions
用于分析和综合教育进展的基于轨迹的框架
- DOI:
10.1145/2470654.2470764 - 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Erik Andersen;Sumit Gulwani;Zoran Popovic - 通讯作者:
Zoran Popovic
Delivery Ghost: Effects of Language Immersion and Interactivity in a Language Learning Game
交付幽灵:语言学习游戏中的语言沉浸和交互性的影响
- DOI:
10.1145/3411763.3451767 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
J. Cho;Erik Andersen;René F. Kizilcec - 通讯作者:
René F. Kizilcec
Crystallize: An Immersive, Collaborative Game for Second Language Learning
Crystallize:用于第二语言学习的沉浸式协作游戏
- DOI:
10.1145/2818048.2820020 - 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Gabriel Culbertson;Erik Andersen;Walker M. White;Daniel Zhang;Malte F. Jung - 通讯作者:
Malte F. Jung
High dose, subcutaneous injections of benzathine penicillin G (SCIP) to prevent rheumatic fever: A single arm, phase IIa trial of safety and pharmacokinetics
大剂量苄星青霉素G皮下注射(SCIP)预防风湿热:一项单臂、IIa期安全性和药代动力学试验
- DOI:
10.1016/j.jinf.2025.106506 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:11.900
- 作者:
Julie Bennett;Sam Salman;Dhevindri Moodley;Hazel Dobinson;Erik Andersen;Anneka Anderson;Brioni Moore;Madhu Page-Sharp;Kevin Batty;Jonathan Carapetis;Michael Baker;Joseph Kado;Laurens Manning - 通讯作者:
Laurens Manning
Social Situational Language Learning through an Online 3D Game
通过在线 3D 游戏进行社交情境语言学习
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Gabriel Culbertson;Shiyu Wang;Malte F. Jung;Erik Andersen - 通讯作者:
Erik Andersen
Erik Andersen的其他文献
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{{ truncateString('Erik Andersen', 18)}}的其他基金
Capacity: Biological Collections: Enhancement of the Caenorhabditis Natural Diversity Resource
能力:生物收藏:增强秀丽隐杆线虫自然多样性资源
- 批准号:
2411431 - 财政年份:2023
- 资助金额:
$ 70.81万 - 项目类别:
Continuing Grant
Capacity: Biological Collections: Enhancement of the Caenorhabditis Natural Diversity Resource
能力:生物收藏:增强秀丽隐杆线虫自然多样性资源
- 批准号:
2224885 - 财政年份:2022
- 资助金额:
$ 70.81万 - 项目类别:
Continuing Grant
CAREER: Discovery of the molecular mechanisms underlying microevolution of phenotypic plasticity in a developmental trait
职业:发现发育性状表型可塑性微进化的分子机制
- 批准号:
1751035 - 财政年份:2018
- 资助金额:
$ 70.81万 - 项目类别:
Continuing Grant
CRII: Cyberlearning: Automatic Discovery of Optimal Progressions of Language Content
CRII:网络学习:自动发现语言内容的最佳进展
- 批准号:
1657176 - 财政年份:2017
- 资助金额:
$ 70.81万 - 项目类别:
Standard Grant
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