Allosteric modulators as novel probes of G-Protein coupled receptor function

变构调节剂作为 G 蛋白偶联受体功能的新型探针

• 批准号: DP0877497
• 负责人: Prof Peter Scammells
• 金额: $ 20.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-02 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877497
• 关键词: Allosteric; modulators; novel; probes; Protein

This research will provide novel mechanistic understanding on the function of one of the largest protein families in the mammalian genome, and the most important family with respect to drug targets. The insights gained thus have direct relevance to drug discovery. The discovery of novel G protein-coupled receptor (GPCR) allosteric enhancers will not only lead to potentially new therapeutic agents, but can significantly value-add to other national research efforts focusing on GPCR structural biology.

这项研究将为哺乳动物基因组中最大的蛋白质家族之一的功能提供新的机制理解，并且是药物靶点方面最重要的家族。 因此，获得的见解与药物发现直接相关。 新的G蛋白偶联受体（GPCR）变构增强剂的发现不仅会导致潜在的新的治疗药物，但可以显着增值的其他国家的研究工作集中在GPCR结构生物学。