Understanding allosteric modulation and functional selectivity at G Protein-Coupled Receptors (GPCRs)

了解 G 蛋白偶联受体 (GPCR) 的变构调节和功能选择性

• 批准号: DP110100687
• 负责人: Prof Peter Scammells
• 金额: $ 29.56万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-04-30 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110100687
• 关键词: Understanding; allosteric; modulation; functional; selectivity

GPCRs are an important superfamily of proteins that are involved in a myriad of physiological processes and a wide range of serious illnesses. This project seeks to gain a more detailed understanding of new mechanisms of GPCR modulation and function that will be of direct relevance to drug discovery.

GPCR是一个重要的蛋白质超家族，参与无数的生理过程和各种严重疾病。该项目旨在更详细地了解与药物发现直接相关的GPCR调节和功能的新机制。