Synthesis of Novel Dual Acting, Selenium Containing Antioxidants

新型双作用含硒抗氧化剂的合成

• 批准号: DP0662989
• 负责人: Prof Peter Scammells
• 金额: --
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0662989
• 关键词: Synthesis; Novel; Dual; Acting; Selenium

Ischemic heart disease and chronic inflammation afflict a large segment of the Australian population, especially the ageing. These states are associated with free-radicals and other reactive oxygen species and can be controlled to some extent by the application of adenosine therapy. This project will combine the activity of adenosine agonists and enhancers with selenium-containing antioxidants, used to quench reactive oxygen species, to provide a powerful new class of pharmaceutical products designed to enhance the quality of life of Australians afflicted by diseases propagated by free-radicals.

缺血性心脏病和慢性炎症困扰着澳大利亚人口的很大一部分，特别是老年人。 这些状态与自由基和其他活性氧有关，并且可以通过应用腺苷治疗在一定程度上控制。 该项目将联合收割机将腺苷激动剂和增强剂的活性与用于淬灭活性氧的含硒抗氧化剂相结合，以提供一种强大的新型药品，旨在提高受自由基传播疾病折磨的澳大利亚人的生活质量。