PFI:AIR-TT: Self-adaptive growing rod for the treatment of pediatric scoliosis
PFI:AIR-TT:用于治疗小儿脊柱侧弯的自适应生长棒
基本信息
- 批准号:1602045
- 负责人:
- 金额:$ 19.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This PFI:AIR Technology Translation project focuses on translating a novel titanium alloy to address the need for improving the outcome and reducing implant-related complications during growing rod treatment of adolescent scoliosis. The adaptive growing rod is important because of its potential to reduce the high incidence of implant loosening and failure, which are the primary sources of complications in the treatment of severe early-onset scoliosis in children and often necessitate costly and painful revision surgeries. The project will result in a working prototype of an adaptive growing rod and demonstrate its feasibility in a standardized biomechanics model. This device has the unique features of simultaneous high strength and ultra-low stiffness matching that of human bone, and the ability to vary its stiffness depending on location. When compared to the leading competing growing rods based on the Harrington rods system in this market, these features reduce the number of revision procedures required by reducing a leading source of complications, facilitating healthy development of the spine from better load sharing, and improving the overall efficacy for treatment of severe scoliosis in children. This project addresses the following technology gaps as it translates from research discovery toward commercial application: there is a current lack of quantitative understanding of how stress at the bone-screw interface is affected by implant stiffness in growing rod constructs. This is important because high stress at the bone-screw interface is believed to be responsible for implant loosening and pull-outs. Furthermore, it is not known how location-dependent implant stiffness modifies such stress. The project seeks to bridge these gaps by quantitatively monitoring how stress at the bone-screw interface is affected by variations in the implant stiffness introduced by microstructural engineering and thermo-mechanical training in a Ti-Nb alloy. Experiments are performed using a modified ASTM standard model that accounts for the changing stiffness of the growing spine. In addition, personnel involved in this project, including a Ph.D. level graduate student and undergraduate researchers, will receive entrepreneurship and technology translation experiences through direct involvement in the customer development process. Students will participate in all conversations with surgeons, hospital officials, regulatory personnel, and medical devices manufacturers. Students will be asked to make customer contacts independently, and receive training of the lean-startup strategy central to the NSF I-Corps program. The project engages pediatric orthopedic surgeons and a medical devices manufacturer to ensure a clear and current understanding of clinical needs and challenges, as well as regulatory and reimbursement hurdles of this technology translation effort from research discovery toward commercial reality.
该PFI:AIR技术翻译项目的重点是翻译一种新型钛合金,以满足青少年脊柱侧凸矫形棒治疗期间改善结局和减少植入物相关并发症的需求。 自适应生长棒很重要,因为它有可能降低植入物松动和失效的高发生率,这是儿童严重早发性脊柱侧凸治疗中并发症的主要来源,通常需要昂贵和痛苦的翻修手术。 该项目将产生一个自适应生长棒的工作原型,并在标准化生物力学模型中证明其可行性。该器械具有与人骨相匹配的同时高强度和超低刚度的独特功能,并且能够根据位置改变其刚度。 与市场上基于哈灵顿棒系统的主要竞争生长棒相比,这些特征通过减少主要并发症来源、通过更好的载荷分配促进脊柱健康发育以及提高治疗儿童重度脊柱侧凸的总体疗效,减少了所需的翻修手术次数。 该项目解决了以下技术差距,因为它从研究发现转化为商业应用:目前缺乏定量的理解,在骨螺钉界面的应力是如何影响种植体刚度在增长棒结构。 这一点很重要,因为骨-螺钉界面处的高应力被认为是导致植入物松动和拔出的原因。 此外,还不知道位置依赖性植入物刚度如何改变这种应力。 该项目旨在通过定量监测骨-螺钉界面处的应力如何受到钛铌合金中微结构工程和热机械训练引入的植入物刚度变化的影响来弥合这些差距。 使用修改后的ASTM标准模型进行实验,该模型考虑了脊柱生长的刚度变化。 此外,参与该项目的人员,包括一名博士。研究生和本科研究人员将通过直接参与客户开发过程获得创业和技术翻译经验。 学生将参与与外科医生,医院官员,监管人员和医疗设备制造商的所有对话。 学生将被要求独立地与客户联系,并接受NSF I-Corps计划的精益创业战略培训。 该项目聘请儿科骨科医生和医疗设备制造商,以确保对临床需求和挑战的清晰和当前的理解,以及从研究发现到商业现实的技术转化工作的监管和报销障碍。
项目成果
期刊论文数量(0)
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专利数量(0)
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Ji Ma其他文献
Data-driven trajectory-based analysis and optimization of airport surface movement
数据驱动的基于轨迹的机场表面运动分析和优化
- DOI:
10.1016/j.trc.2022.103902 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Ji Ma;J. Zhou;M. Liang;D. Delahaye - 通讯作者:
D. Delahaye
Characterization of Th1- and Th2-associated Chemokine Receptor Expression in Spleens of Patients with Immune Thrombocytopenia
免疫性血小板减少症患者脾脏中 Th1 和 Th2 相关趋化因子受体表达的特征
- DOI:
10.1007/s10875-013-9883-4 - 发表时间:
2013 - 期刊:
- 影响因子:9.1
- 作者:
Shu;Ji Ma;Hui;Zong;Wei;Juan;Ai;Ni Zhang;Jun;Cheng‐shan Guo;Yan Shi;M. Hou;J. Peng - 通讯作者:
J. Peng
Orientation dependence of superelasticity in FeMnAlNi single crystals under compression
FeMnAlNi 单晶压缩下超弹性的取向依赖性
- DOI:
10.1016/j.scriptamat.2019.02.034 - 发表时间:
2019 - 期刊:
- 影响因子:6
- 作者:
L. Tseng;Ji Ma;Y. Chumlyakov;I. Karaman - 通讯作者:
I. Karaman
SU(2) Non-Abelian Photon
SU(2) 非阿贝尔光子
- DOI:
10.1007/s10773-017-3482-8 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Xiangyao Wu;Xiao;Hong Li;Si;Ji Ma;Ji;Yu Liang - 通讯作者:
Yu Liang
Probabilistic Slider: A Tool for Visualizing Fuzzy Segmentation Uncertainties
概率滑块:可视化模糊分割不确定性的工具
- DOI:
10.1109/access.2021.3057681 - 发表时间:
2021 - 期刊:
- 影响因子:3.9
- 作者:
Ji Ma;Jinjin Chen;Liye Chen;Jiazhou Chen;Xujia Qin;Mingyu Bao - 通讯作者:
Mingyu Bao
Ji Ma的其他文献
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{{ truncateString('Ji Ma', 18)}}的其他基金
Lattice instability and room temperature hyper-diffusion in metastable phase-transforming alloys
亚稳态相变合金中的晶格不稳定性和室温超扩散
- 批准号:
2104839 - 财政年份:2021
- 资助金额:
$ 19.91万 - 项目类别:
Standard Grant
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