Understanding how the rheological behavior of biological fluids is related to health

了解生物体液的流变行为与健康的关系

• 批准号: 1604903
• 负责人: William Schultz
• 金额: $ 31.5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1604903&HistoricalAwards=false
• 关键词: Understanding; how; rheological; behavior; biological

PI: Schultz, WilliamProposal Number: 1604903This proposal is based upon the hypothesis that health is reflected by changes in biological fluids, most important and accessible of which is saliva, and these changes affect the rheological properties of biofluids. This hypothesis further stipulates that rheological characterization of saliva, and quantification of its properties, can provide information about a person's health. Saliva rheology is similar to that of water, making measuring non-Newtonian properties difficult. Capillary Break-up Rheometry (CBR) is commonly used to determine extensional parameters of such fluids. It is proposed to re-examine CBR foundations with differential one-dimensional models to eliminate the large correction factors required when measuring the radius-thinning rate at the filament midpoint. Unlike previous methods, new analysis recognizes curvature gradients that drive the flow and therefore the free surface profile evolution is required to accurately determine extensional properties. This analysis is consistent with filament evolution all the way through beads-on-a-string formation that they have been observed in Newtonian and preliminary saliva demonstrations. Next the spatially-varying surface tension in Newtonian analysis is used to study the role of surfactants in filament dynamics as well as the more prominent extensional viscoelastic properties of long-chained molecules (such as mucins) or by surfactants (such as in soap films) that could be interpreted as stickiness. Unlike saliva viscoelasticity, the role of surface activity in saliva filament formation and its implications on health diagnosis have not yet been considered. Characterizing saliva rheological properties could guide the development of more effective saliva substitutes, stimulants, and hydrating liquids for xerostomia or dysphagia. The co-PIs will collaborate with U. Ghana Biomedical Engineering Department to study dysphagia problems prevalent in local populations. Techniques developed through this project can help to characterize other biological and industrial fluids. There are also plans to engage in activities to promote women in engineering including educational outreach to over 200 4th through 6th grade girls through the University of Michigan FEMMES program and involving undergraduate women in research.

主要研究者：Schultz，WilliamProposal Number：1604903该提案基于以下假设：健康是通过生物流体的变化来反映的，其中最重要和最容易获得的是唾液，并且这些变化影响生物流体的流变特性。该假说进一步规定，唾液的流变学表征及其性质的量化可以提供关于人的健康的信息。唾液的流变学与水的流变学相似，这使得测量非牛顿性质变得困难。毛细管破裂流变仪（CBR）通常用于确定此类流体的拉伸参数。有人建议重新检查CBR基础差分一维模型，以消除大的修正系数时，测量的半径变薄率在长丝中点。与以前的方法不同，新的分析认识到曲率梯度，驱动流，因此需要自由表面轮廓的演变，以准确地确定拉伸性能。这种分析是一致的长丝演变的所有方式，通过珠串形成，他们已经观察到在牛顿和初步的唾液演示。接下来，牛顿分析中的空间变化的表面张力被用来研究表面活性剂在长丝动力学中的作用，以及长链分子（如粘蛋白）或表面活性剂（如肥皂膜）更突出的拉伸粘弹性，可以解释为粘性。与唾液粘弹性不同，表面活性在唾液丝形成中的作用及其对健康诊断的影响尚未被考虑。表征唾液流变学特性可以指导开发更有效的唾液替代品，兴奋剂和用于口干症或吞咽困难的水合液体。联合PI将与U。加纳生物医学工程部研究当地人群中普遍存在的吞咽困难问题。通过该项目开发的技术可以帮助表征其他生物和工业流体。还计划开展活动，促进妇女从事工程学工作，包括通过密歇根大学FEMMES方案向200多名四年级至六年级女生提供教育宣传，并让女大学生参与研究。