In-situ Monitoring and Active Controls of Individual Nucleation and Crystal Growth through Nanoscale Mass Transport

通过纳米级传质对单个成核和晶体生长进行原位监测和主动控制

• 批准号: 1610616
• 负责人: Gangli Wang
• 金额: $ 42.1万
• 依托单位: Georgia State University Research Foundation, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1610616&HistoricalAwards=false
• 关键词: situ; Monitoring; Active; Controls; Individual

This project is funded by the Chemical Measurement and Imaging program of Chemistry Division at the National Science Foundation. Professor Gangli Wang and his group members at Georgia State University develop new analytical methods providing knowledge of early-stage nucleation and subsequent crystal growth at greater time and spatial resolutions than is otherwise possible. High quality single crystals display chemical, physical, and mechanical properties, and have superb performance in practical applications in chemical, pharmaceutical and materials industries. Lack of capable methods to measure and to actively control the crystallization process has been a limit on the advance of fundamental research as well as practical applications. The capability to measure the dynamic process in-situ and thus to actively control crystal formation is expected to establish much-needed high throughput and high efficiency crystallization technology. The broader impacts are demonstrated in that the proposed aims advance the paradigm of crystallization. Students from underrepresented groups and from disadvantageous backgrounds in metro Atlanta gain first-hand knowledge and experiences through the grant activities. The overarching goal of this proposal is to establish an electroanalytical methodology combined with optical imaging that enables in-situ monitoring and active controls of single nucleus formation and single crystal growth. Analytical platforms are being developed with optimized nanostructures and surface functionalities to spatially confine the formation and growth of a single nucleus at the earliest stage (molecular assembly) one at a time. The kinetics of a single crystal nucleus formation and growth, governed by local transport of the target molecules around the nucleus, are controlled externally via a programmed potential waveform. Active control of mass transport is another superior advantage over the passive diffusion mechanism adopted in conventional crystallization methods. Because the transport and assembly processes are associated with changes in ionic current signals as well as optical properties, in-situ monitoring and adjustments are performed to tailor the nucleation and growth kinetics of individual events.

该项目由美国国家科学基金会化学部化学测量和成像计划资助。格鲁吉亚州立大学的Gangli Wang教授和他的小组成员开发了新的分析方法，以更高的时间和空间分辨率提供早期成核和随后的晶体生长的知识。高质量的单晶显示出化学、物理和机械性能，在化学、制药和材料工业的实际应用中具有卓越的性能。缺乏有效的方法来测量和主动控制结晶过程已经限制了基础研究的进展以及实际应用。原位测量动态过程并因此主动控制晶体形成的能力有望建立急需的高产量和高效率结晶技术。更广泛的影响表明，提出的目标推进结晶的范式。来自亚特兰大大都会代表性不足的群体和不利背景的学生通过赠款活动获得第一手知识和经验。该提案的总体目标是建立一种电分析方法，结合光学成像，使原位监测和主动控制的单核形成和单晶生长。正在开发具有优化的纳米结构和表面功能的分析平台，以在空间上限制单个核在最早阶段（分子组装）的形成和生长。由靶分子在核周围的局部运输控制的单晶核形成和生长的动力学通过编程的电势波形在外部控制。与传统结晶方法中采用的被动扩散机制相比，质量传输的主动控制是另一个上级优势。由于运输和组装过程与离子电流信号以及光学性质的变化相关，因此进行原位监测和调整以定制各个事件的成核和生长动力学。