The role of electrostatic charge in airway deposition of aerosols

静电荷在气溶胶气道沉积中的作用

• 批准号: DP160102577
• 负责人: Prof Hak-Kim Chan
• 金额: $ 26.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-03-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102577
• 关键词: role; electrostatic; charge; airway; deposition

This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly reduce health risks and costs. They may also be used to enable the development of new inhalation technologies based on electrostatic charge to improve aerosol drug delivery to the lungs of patients with respiratory diseases.

本项目旨在揭示静电电荷在控制呼吸道气溶胶沉积中的重要性。预期的结果是一个经过验证的数学模型，可以准确预测带电气溶胶粒子在人类呼吸道中的沉积行为。研究结果可能最终用于支持新的预防措施，以减少吸入有害空气传播颗粒的肺沉积，从而显著降低健康风险和成本。它们还可用于开发基于静电电荷的新吸入技术，以改善呼吸系统疾病患者肺部的气溶胶药物输送。