Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria

实现噬菌体的气溶胶递送以击败抗生素抗性细菌

• 批准号: DP150103953
• 负责人: Prof Hak-Kim Chan
• 金额: $ 37.71万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-02-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103953
• 关键词: Enabling; aerosol; delivery; phages; defeat

This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficacious and stable formulations of bacteriophages for easy delivery by inhalation as aerosols with a long shelf-life, making them a commercially viable product. The expected research outcome can lead to an economic and efficient technology to produce phage powders for novel treatment strategies of infections by inhalation.

该项目旨在探索噬菌体的使用，以生产一种安全、自然和高效的传统抗生素替代品。由多重耐药的革兰氏阴性细菌引起的呼吸道感染是全球的一个主要健康问题，每年给澳大利亚造成的损失超过1.5亿美元。每年约有5000名澳大利亚人死于抗生素耐药性感染。该项目旨在生产有效和稳定的噬菌体配方，便于通过吸入作为气雾剂输送，并具有较长的货架期，使其成为商业上可行的产品。预期的研究结果可能导致一种经济而有效的技术来生产噬菌体粉末，用于治疗吸入性感染的新策略。