Understanding bacteriophage deactivation and stabilisation in formulations

了解配方中噬菌体的失活和稳定性

• 批准号: DP210102526
• 负责人: Prof Hak-Kim Chan
• 金额: $ 38.03万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-24 至 2025-02-23
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102526
• 关键词: Understanding; bacteriophage; deactivation; stabilisation; formulations

Bacteriophages (phages) are viruses that kill pathogenic bacteria without causing harms to the eco-balance. They can provide a safe and highly effective antimicrobial measure for biocontrol when formulated properly. This project aims to develop a mechanistic understanding of the physicochemical factors responsible for stabilising and deactivating phages in a wide range of formulations. It will create new knowledge on key relationships between phage chemistry, phage-excipient interactions and phage stability. The research outcomes would significantly benefit Australia by enabling commercial development in the high value-adding area of environmentally friendly antimicrobial products.

噬菌体（Bacteriophages，缩写为BPHs）是一种能够杀死病原菌而不破坏生态平衡的病毒。 当适当配制时，它们可以为生物防治提供安全和高效的抗菌措施。该项目旨在从机理上理解负责稳定和灭活多种配方中的杀虫剂的物理化学因素。它将创造关于噬菌体化学、噬菌体-赋形剂相互作用和噬菌体稳定性之间的关键关系的新知识。研究成果将使澳大利亚在环保抗菌产品的高附加值领域实现商业开发，从而使澳大利亚受益匪浅。