Understanding bacteriophage deactivation and stabilisation in formulations

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Bacteriophages (phages) are viruses that kill pathogenic bacteria without causing harms to the eco-balance. They can provide a safe and highly effective antimicrobial measure for biocontrol when formulated properly. This project aims to develop a mechanistic understanding of the physicochemical factors responsible for stabilising and deactivating phages in a wide range of formulations. It will create new knowledge on key relationships between phage chemistry, phage-excipient interactions and phage stability. The research outcomes would significantly benefit Australia by enabling commercial development in the high value-adding area of environmentally friendly antimicrobial products.