EAPSI: Nuclear Magnetic Resonance Correlation Studies for Identification of Water and Polymer Populat

EAPSI：用于识别水和聚合物群体的核磁共振相关研究

• 批准号: 1614189
• 负责人: Sarah Mailhiot
• 金额: $ 0.54万
• 依托单位: Mailhiot Sarah
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1614189&HistoricalAwards=false
• 关键词: EAPSI; Nuclear; Magnetic; Resonance; Correlation

The mobility of fluid and the structure of viscoelastic substances such as gels is important to human health and many key industries. One example of a gel is articular cartilage, the tissue that lines joints and allows for efficient motion such as walking. This study conducts nuclear magnetic resonance correlation studies to characterize the fluid mobility and pore structure of a model cartilage, aiming to identify water and polymer populations in a complex biopolymer system. The information will improve understanding about the relationship between polymer systems and water in a viscoelastic substance. Although these studies focus on cartilage models, many mammalian tissues and many commercial applications are dependent on water and polymer diffusion and how they interact, suggesting potential broad impact to the work. The project is a collaboration with Dr. Petrik Galvosas at the McDiarmid Institute for Advanced Materials and Nanotechnology at Wellington University in New Zealand and enables a U.S. graduate student to learn new techniques to expand her skillset as an experimentalist. Articular cartilage is a mammalian tissue that is not connected to the blood stream and is therefore dependent on molecular mobility of water for nutrient flow and survival. It is also a complex heterogeneous, anisotropic, polymer composite composed of fluid, collagen, and proteoglycans. This study will used Pulsed Field Gradient (PFG) Nuclear Magnetic Resonance (NMR) to characterize the internal structure of a model cartilage, collagen hydrogels, as a function of collagen content. This information is critical to understanding the structure-function relationship of articular cartilage, and in general, gels. The findings will be applicable to fields such as drug development, animal range sciences, and plant physiology.This award under the East Asia and Pacific Summer Institutes program supports summer research by a U.S. graduate student and is jointly funded by NSF and the Royal Society of New Zealand.

流体的流动性和粘弹性物质（如凝胶）的结构对人类健康和许多关键行业都很重要。凝胶的一个例子是关节软骨，该组织排列关节并允许有效的运动，如行走。本研究进行核磁共振相关性研究，以表征模型软骨的流体流动性和孔结构，旨在识别复杂生物聚合物系统中的水和聚合物群体。这些信息将提高对粘弹性物质中聚合物系统和水之间关系的理解。虽然这些研究主要集中在软骨模型上，但许多哺乳动物组织和许多商业应用都依赖于水和聚合物的扩散以及它们如何相互作用，这表明了对这项工作的潜在广泛影响。该项目是与新西兰惠灵顿大学McDiarmid先进材料和纳米技术研究所的Petrik Galvosas博士合作，使美国研究生能够学习新技术，以扩大她作为实验人员的技能。关节软骨是一种哺乳动物组织，它不与血流相连，因此依赖于水的分子流动性来获得营养流动和生存。它也是一种复杂的异质、各向异性的聚合物复合材料，由流体、胶原蛋白和蛋白聚糖组成。本研究将使用脉冲场梯度（PFG）核磁共振（NMR）来表征模型软骨（胶原蛋白水凝胶）的内部结构，作为胶原蛋白含量的函数。这些信息对于理解关节软骨和一般凝胶的结构-功能关系至关重要。 该研究成果将应用于药物开发、动物牧场科学和植物生理学等领域。该奖项是东亚和太平洋夏季研究所计划下的一个奖项，支持美国研究生的夏季研究，由NSF和新西兰皇家学会共同资助。