SBIR Phase I: Modernizing the diagnosis, monitoring, and treating of substance use disorders via an integrated technology platform

SBIR 第一阶段：通过集成技术平台实现物质使用障碍的诊断、监测和治疗现代化

• 批准号: 1621825
• 负责人: Patrik Schmidle
• 金额: $ 22.5万
• 依托单位: Mentor on the Go LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1621825&HistoricalAwards=false
• 关键词: SBIR; Phase; Modernizing; diagnosis; monitoring

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will be to transform how substance use disorders (SUDs) are diagnosed, monitored and treated by creating an integrated technology platform for health care providers. One important application is the early detection of risky substance use behavior that, if treated in the beginning stages, will reduce the rate of fully developed SUDs. The research and development performed on this Small Business Innovation Research (SBIR) Phase I project will be key to creating a novel bio-sensor based approach to diagnosing, monitoring and treating substance abuse patients. The collected bio-sensor data can also inform treatment solutions to help address this tremendous problem, which affects millions of people, costs the US economy billions of dollars annually, and incurs a significant human cost in terms of lost lives, broken families, and unfulfilled potential. There is also strong demand for a robust solution in places where substance use detection and monitoring is mandated for safety reasons, including the court system and the military services, as well as occupations like air traffic controllers, pilots, train operators, truck drivers, bus drivers, and operators of heavy machinery.The proposed project will focus on integrating biosensors with smartphone technology to detect, collect, transmit, store, and analyze relevant biodata and to push resulting behavior change instructions to the user. By establishing a connection between the sensors and a smartphone application we will report substance abuse treatment outcome data much more accurately than is currently possible via self-reporting. This system will address engineering, manufacturing, and calibration challenges of a highly accurate diagnostic tool. This technology bypasses the limitations of existing methods with a dramatically different approach. The technology aims to greatly simplify the process of SUD diagnosis and treatment by empowering health care providers to implement accurate data collection, early detection, and custom-tailored intervention within the context of any routine office visit. The proposed project will address the development of a substance use measuring biosensor and assess the sensor lifetime, stability, reproducibility, and sensitivity. It is intended to develop a biosensor that patients can wear for a period of time, that we can establish a meaningful connection between the sensor and the mobile application to replace self-reporting, and that concept support can be gained from broader representation of primary care physicians and major insurance companies

该小企业创新研究 (SBIR) 第一阶段项目的更广泛影响/商业潜力将是通过为医疗保健提供者创建一个综合技术平台来改变药物使用障碍 (SUD) 的诊断、监测和治疗方式。一个重要的应用是早期检测危险物质使用行为，如果在开始阶段进行治疗，将降低完全发展的 SUD 的发生率。小企业创新研究 (SBIR) 第一阶段项目的研究和开发将是创建一种基于生物传感器的新型方法来诊断、监测和治疗药物滥用患者的关键。 收集到的生物传感器数据还可以为治疗解决方案提供信息，以帮助解决这一巨大问题，该问题影响数百万人，每年给美国经济造成数十亿美元的损失，并在人员伤亡、家庭破裂和未实现的潜力方面造成巨大的人员损失。 出于安全原因强制进行药物使用检测和监控的地方，包括法院系统和军事部门，以及空中交通管制员、飞行员、火车操作员、卡车司机、公共汽车司机和重型机械操作员等职业，也强烈需要强大的解决方案。拟议项目将侧重于将生物传感器与智能手机技术集成，以检测、收集、传输、存储和分析相关生物数据，并推送由此产生的行为改变指令 给用户。通过在传感器和智能手机应用程序之间建立连接，我们将比目前通过自我报告更准确地报告药物滥用治疗结果数据。 该系统将解决高精度诊断工具的工程、制造和校准挑战。该技术通过一种截然不同的方法绕过了现有方法的局限性。该技术旨在通过使医疗保健提供者能够在任何常规办公室就诊的情况下实施准确的数据收集、早期检测和定制干预，从而大大简化 SUD 的诊断和治疗过程。 拟议的项目将致力于开发物质使用测量生物传感器，并评估传感器的寿命、稳定性、再现性和灵敏度。 目的是开发一种患者可以佩戴一段时间的生物传感器，我们可以在传感器和移动应用程序之间建立有意义的连接以取代自我报告，并且可以从初级保健医生和主要保险公司的更广泛代表处获得概念支持