SBIR Phase II: Modernizing the diagnosis, monitoring, and treating of substance use disorders via an integrated technology platform

SBIR 第二阶段：通过集成技术平台实现物质使用障碍的诊断、监测和治疗现代化

• 批准号: 1831257
• 负责人: Patrik Schmidle
• 金额: $ 74.82万
• 依托单位: Mentor on the Go LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831257&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Modernizing; diagnosis

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will transform how alcohol use disorders (AUDs) are diagnosed, monitored, and treated by the further development of a micro-biosensor system for health care providers. An implantable micro-biosensor that reliably detects, monitors, and tracks alcohol consumption allows for more accurate diagnosis so the appropriate treatment solution can be prescribed and tracked. Our system integrates an implantable micro-biosensor with smartphone technology to continuously detect and monitor, collect, transmit, store, and analyze relevant biodata, pushing resulting behavior change instructions to the user. This creates a revolutionary approach to the diagnosis and treatment of alcohol use disorders by reporting outcome data more accurately and reliably than current, self-reporting methods. Our system potentially yields multiple societal benefits, including lower treatment costs and increased treatment accessibility. Additionally, it could reduce both economic and social costs through the identification of people at risk thereby increasing the number of people who seek and receive treatment. This Small Business Innovation Research (SBIR) Phase II project will focus on refining the design and functionalization of an injectable alcohol micro-biosensor, developing a wearable device, and testing the alcohol micro-biosensor in animals. Once fully developed, our system for detecting, monitoring, and treating alcohol use disorders will consist of three components: 1) a multi-plex micro-biosensor, small enough to be directly injected under the skin. The sensor is customizable to continuously monitor and measure alcohol; 2) a wearable sensor device that provides power to the injected micro-biosensor while collecting the measured data to transmit to a nearby smartphone or other data aggregator; and 3) a mobile smartphone application developed by our company that uses evidence-based psychotherapy techniques to encourage behavior modification. The anticipated technical results include an implantable micro-biosensor for the continuous monitoring and measuring of alcohol consumption. Additionally, an unobtrusive wearable device that can power the biosensor and store and transmit the data collected is anticipated. Both of these components will have been tested in animals and be ready to move on to testing in humans.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第二阶段项目的更广泛的影响/商业潜力将改变酒精使用障碍（AUD）的诊断，监测和治疗的方式，通过进一步开发微型生物传感器系统为医疗保健提供者。 可植入的微型生物传感器可以可靠地检测、监测和跟踪酒精摄入量，从而实现更准确的诊断，从而可以处方和跟踪适当的治疗方案。我们的系统将可植入的微型生物传感器与智能手机技术集成在一起，以持续检测和监测、收集、传输、存储和分析相关的生物数据，并将由此产生的行为改变指令推送给用户。 这创造了一种革命性的方法来诊断和治疗酒精使用障碍，报告结果数据比目前的自我报告方法更准确，更可靠。我们的系统可能产生多种社会效益，包括降低治疗成本和增加治疗可及性。此外，它还可以通过查明风险人群，从而增加寻求和接受治疗的人数，降低经济和社会成本。 该小型企业创新研究（SBIR）第二阶段项目将专注于改进可注射酒精微生物传感器的设计和功能化，开发可穿戴设备，并在动物中测试酒精微生物传感器。一旦完全开发出来，我们用于检测、监测和治疗酒精使用障碍的系统将由三个组成部分组成：1）一个多功能微型生物传感器，小到足以直接注射到皮肤下。该传感器可定制为连续监测和测量酒精; 2）可穿戴传感器设备，为注入的微型生物传感器提供电力，同时收集测量的数据并传输到附近的智能手机或其他数据聚合器;以及3）由我们公司开发的移动的智能手机应用程序，使用循证心理治疗技术鼓励行为矫正。预期的技术成果包括一种可植入的微型生物传感器，用于连续监测和测量酒精消费量。此外，可以为生物传感器供电并存储和传输收集到的数据的不显眼的可穿戴设备也在意料之中。这两个组件都将在动物身上进行测试，并准备在人体上进行测试。该奖项反映了NSF的法定使命，并被认为是值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估的支持。