I-Corps: Improved Skeletal Visualization Process for Developmental Toxicology and a Novel 3-D Histology Technology
I-Corps:改进的发育毒理学骨骼可视化过程和新颖的 3D 组织学技术
基本信息
- 批准号:1622801
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-01-15 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
When a patient goes in for a cancer biopsy, the doctor removes a piece of tissue from the patient and sends it to a pathologist. The pathologist takes a few very thin slices of this biopsy, places them on a glass microscope slides, stains them and visualizes them on a microscope. From these thin slices the pathologist makes the diagnosis of the disease. The problem with this approach is that these thin slices do not tell the full story of what is going on with the biopsy and do not give a complete picture of what is going on with the disease. Because of this, cancer is frequently misdiagnosed and patients receive inadequate treatment for their disease. This I-Corps team has invented a patent-pending chemical formula called Visikol that is able to render biological tissues like biopsies transparent so that they can be imaged in their entirety instead of thin slices. Using the Visikol core technology this team has developed numerous bio-imaging platforms which it intends to license to pharmaceutical companies and contract research organizations (CROs). This team has already used the Visikol core technology to develop bio-imaging platforms for the visualization of skeletal tissues by CROs and for the 3-D histological visualization of tissues by pathologists. There are many technologies that this group has developed using the Visikol technology, but the scope of this project will be these two bio-imaging platforms. While these platforms are currently market-ready, this group will work directly with potential customers to understand how they will fit into their current processes so that they can be easily adopted. The primary goal for this project over a 6-month period of time is to license the use of each one of these technology platforms to at least one company. During the I-Corps program, the group will reach potential customers through having a table at the Society of Toxicology Trade Show and attending the BIO International partnering sessions. Through these conversations the team will setup material transfer agreements to demonstrate the advantages of our platforms in their labs and transition these pilot studies into licenses.
当病人去做癌症活检时,医生会从病人身上取出一块组织,然后把它送到病理学家那里。病理学家从活检组织中取几片非常薄的切片,将它们放在显微镜载玻片上,染色并在显微镜下观察。病理学家根据这些薄片做出疾病的诊断。这种方法的问题是,这些薄片不能完整地说明活检的情况,也不能完整地说明疾病的情况。正因为如此,癌症经常被误诊,患者接受的治疗不足。这个I-Corps团队发明了一种名为Visikol的正在申请专利的化学配方,它能够使生物组织如活检透明,这样它们就可以整体成像,而不是薄片。利用Visikol的核心技术,该团队开发了许多生物成像平台,并打算将其授权给制药公司和合同研究组织(CRO)。该团队已经使用Visikol核心技术开发了生物成像平台,用于CRO对骨骼组织的可视化和病理学家对组织的三维组织学可视化。该团队使用Visikol技术开发了许多技术,但该项目的范围将是这两个生物成像平台。虽然这些平台目前已准备就绪,但该团队将直接与潜在客户合作,了解它们如何适应当前的流程,以便易于采用。该项目的主要目标是在6个月的时间内将这些技术平台中的每一个的使用许可给至少一家公司。在I-Corps计划期间,该集团将通过在毒理学贸易展协会和参加BIO国际合作会议的方式接触潜在客户。通过这些对话,该团队将建立材料转让协议,以在他们的实验室中展示我们平台的优势,并将这些试点研究转化为许可证。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Johnson其他文献
Buy-side barriers to e-business technology in the healthcare sector
- DOI:
10.1504/ijhtm.2013.055090 - 发表时间:
2013-07 - 期刊:
- 影响因子:1
- 作者:
Michael Johnson - 通讯作者:
Michael Johnson
Electrochemistry of Cobalt‐containing Species
含钴物质的电化学
- DOI:
10.1002/9783527610426.bard070019 - 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
Michael Johnson;D. Peters - 通讯作者:
D. Peters
NCCN Guidelines® Insights: Kidney Cancer, Version 2.2024.
NCCN 指南®见解:肾癌,版本 2.2024。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
R. Motzer;Eric Jonasch;Neeraj Agarwal;A. Alva;Hilary Bagshaw;Michael Baine;Kathryn E. Beckermann;M. Carlo;Toni K. Choueiri;B. A. Costello;I. Derweesh;Arpita Desai;Yasser Ged;Saby George;John L Gore;Andrew Gunn;Naomi Haas;Michael Johnson;Payal Kapur;Jennifer King;Christos Kyriakopoulos;Elaine T Lam;Primo N. Lara;Clayton Lau;Bryan Lewis;David C. Madoff;Brandon J. Manley;M. Michaelson;Amir Mortazavi;L. Ponsky;Sundhar Ramalingam;B. Shuch;Zachary L Smith;Jeffrey A. Sosman;Randy F. Sweis;M. Zibelman;Ryan Schonfeld;MaryElizabeth Stein;Lisa A. Gurski - 通讯作者:
Lisa A. Gurski
Understanding the Role of Research in the Evolution of Fertilizer Policies in Malawi
了解研究在马拉维肥料政策演变中的作用
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
Michael Johnson;R. Birner - 通讯作者:
R. Birner
Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II)
比较左乙拉西坦和唑尼沙胺与标准癫痫治疗方法的有效性和成本效益的实用随机对照试验的研究方案:标准抗癫痫药物与新型抗癫痫药物的比较 (SANAD-II)
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:2.9
- 作者:
S. Balabanova;Claire Taylor;G. Sills;G. Burnside;C. Plumpton;Phillip E M Smith;R. Appleton;J. Leach;Michael Johnson;G. Baker;M. Pirmohamed;D. Hughes;P. Williamson;C. Tudur;A. Marson - 通讯作者:
A. Marson
Michael Johnson的其他文献
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{{ truncateString('Michael Johnson', 18)}}的其他基金
Collaborative Research: Experimental General Relativity using Radio Interferometry of a Black Hole Photon Ring
合作研究:利用黑洞光子环射电干涉测量的实验广义相对论
- 批准号:
2307887 - 财政年份:2023
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
REU Site: The National Summer Undergraduate Research Project
REU 网站:国家暑期本科生研究项目
- 批准号:
2149582 - 财政年份:2022
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Online Undergraduate Resource Fair for the Advancement and Alliance of Marginalized Mathematicians
边缘化数学家进步和联盟在线本科生资源博览会
- 批准号:
2230388 - 财政年份:2022
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
RAPID: The National Summer Undergraduate Research Project (NSURP), a Virtual Platform for Engaging Underrepresented Minorities in STEM
RAPID:国家暑期本科生研究项目 (NSURP),一个让代表性不足的少数群体参与 STEM 的虚拟平台
- 批准号:
2128247 - 财政年份:2021
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
The Value of Creative Growth: making growth work for creative enterprise
创意增长的价值:让创意企业的增长发挥作用
- 批准号:
AH/S004653/1 - 财政年份:2019
- 资助金额:
$ 5万 - 项目类别:
Fellowship
An integrated systems-level framework for deciphering multidrug resistant epilepsy.
用于破译多重耐药性癫痫的集成系统级框架。
- 批准号:
MR/S02638X/1 - 财政年份:2019
- 资助金额:
$ 5万 - 项目类别:
Research Grant
SBIR Phase II: Digitization of Skeletal Evaluations for Developmental and Reproductive Toxicology (DART) Studies.
SBIR 第二阶段:发育和生殖毒理学 (DART) 研究骨骼评估的数字化。
- 批准号:
1852639 - 财政年份:2019
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
SBIR Phase I: Digitization of Skeletal Evaluations for Developmental and Reproductive Toxicology (DART) Studies.
SBIR 第一阶段:发育和生殖毒理学 (DART) 研究骨骼评估的数字化。
- 批准号:
1745650 - 财政年份:2018
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Connected STEM - Promoting STEM Education through Connected Devices and Building Automation
互联 STEM - 通过互联设备和楼宇自动化促进 STEM 教育
- 批准号:
1615019 - 财政年份:2016
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
相似海外基金
SBIR Phase I: Improved Skeletal Visualization Technology for Developmental and Reproductive Toxicology (DART) Studies
SBIR 第一阶段:用于发育和生殖毒理学 (DART) 研究的改进骨骼可视化技术
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1622083 - 财政年份:2016
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Improved Accuracy of NIRS-based Skeletal Muscle Oxygen Saturation Measurement through Model Creation and Advanced Signal Processing Techniques
通过模型创建和先进的信号处理技术提高基于 NIRS 的骨骼肌氧饱和度测量的准确性
- 批准号:
8879942 - 财政年份:2015
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Doctoral Dissertation Research: Improved Skeletal Age-at-Death Estimation and Its Impact on Archaeological Analyses
博士论文研究:改进的骨骼死亡年龄估计及其对考古分析的影响
- 批准号:
1455810 - 财政年份:2015
- 资助金额:
$ 5万 - 项目类别:
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Engineering of Irradiation-Sterilized Skeletal Allograft for Improved Clinical Outcomes
用于改善临床结果的辐射灭菌同种异体骨骼移植工程
- 批准号:
310319 - 财政年份:2014
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Operating Grants
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RGS14 KO 中提高运动耐力的骨骼肌基础
- 批准号:
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AC5 KO 中提高运动耐力的骨骼肌基础
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AC5 KO 中提高运动耐力的骨骼肌基础
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Skeletal Muscle Basis for Improved Exercise Endurance in RGS14 KO
RGS14 KO 中提高运动耐力的骨骼肌基础
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