STTR Phase I: Production of aromatic commodity chemicals via the coumalic acid platform using the catalyzed Diels-­‐Alder reaction in a continuous flow reactor

STTR 第一阶段：使用催化 Diels 通过香豆酸平台生产芳香族商品化学品

• 批准号: 1622799
• 负责人: Robert Johnson
• 金额: $ 22.5万
• 依托单位: SusTerea Biorenewables LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1622799&HistoricalAwards=false
• 关键词: STTR; Phase; Production; aromatic; commodity

The broader impact/commercial potential of this Small Business Technology Transfer Phase I project is the accelerated utilization of crop materials for the manufacture of biobased aromatic chemicals such as terephthalic acid and benzoic acid, which currently have global market value of $60 billion and $200 million, respectfully. This project focusses on benzoic acid (applications ranging from food additives to plasticizers) as the first commercial target to gain a market foothold and develop this technology. This technology will provide a biobased source for benzoic acid, which is currently produced almost exclusively from the oxidation of petrochemical toluene. Situated in Iowa, the epicenter of biomass production in the United States, SusTerea Biorenewables LLC can impact the rural economy, expand the utilization of crop materials beyond ethanol into the production of biobased chemicals. The technical objectives in this Phase I research project is development of the biobased coumalic acid platform, for producing an array of industrially important aromatic molecules. The technological basis for the project began with the identification by researcehers at the NSF Engineering Research Center, Center for Biorenewable Chemicals (CBiRC) of a chemical catalysis pathway to transform an industrially optimized fermentation product (malic acid) into coumalic acid and the discovery that coumalic acid could be used to produce an array of aromatics such as benzoic acid, terephthalic acid, and dimethyl terephthalate. Thus, coumalic acid has the potential to become a platform chemical opportunity in the burgeoning biorenewable chemical industry. First, the reaction conditions including temperature, pressure and solvent using an industrially relevant bench scale continuous flow reactor will be optimized. Second, new catalysts to substitute noble metals will be explored for the key aromatization step. Third, this experimental data will be used to construct a preliminary process design and a techno- economic model towards developing a scalable production technology.

这个小型企业技术转移I阶段项目的更广泛的影响/商业潜力是加速使用农作物材料来生产生物基芳香化学物质，例如苯甲酸和苯甲酸，目前具有6000亿美元的全球市场价值，并尊重2亿美元。该项目的重点是苯甲酸（从食品添加剂到增塑剂的应用）是获得市场立足并开发这项技术的第一个商业目标。这项技术将为苯甲酸提供生物基源，目前几乎完全由石化甲苯的氧化产生。 Susterea Biorewables LLC位于爱荷华州，是美国生物量生产的震中，可能会影响农村经济，扩大乙醇以外的作物材料的利用，以生产生物基化学品的生产。 I阶段研究项目中的技术目标是生物基甲酸平台的开发，用于生产一系列重要的芳族分子。 The technological basis for the project began with the identification by researcehers at the NSF Engineering Research Center, Center for Biorenewable Chemicals (CBiRC) of a chemical catalysis pathway to transform an industrially optimized fermentation product (malic acid) into coumalic acid and the discovery that coumalic acid could be used to produce an array of aromatics such as benzoic acid, terephthalic acid, and dimethyl邻苯二甲酸酯。因此，黄甲酸有可能成为迅速发展的生物生物化学工业的平台化学机会。首先，将优化使用与工业相关的基准尺度连续流动反应器在内的反应条件，包括温度，压力和溶剂。其次，将探索替代高贵金属的新催化剂，以便为关键的芳香化步骤探索。第三，该实验数据将用于构建初步过程设计和技术经济模型，以开发可扩展的生产技术。