Reduzierung der Unsicherheiten bei der klinischen Dosimetrie und bei der Dosisberechnung für Ionenstrahlen mit Hilfe von Monte Carlo Simulationen

使用蒙特卡罗模拟减少离子束临床剂量测定和剂量计算的不确定性

• 批准号: 22505257
• 负责人: Professor Dr. Jürgen Debus
• 金额: --
• 依托单位: Klinik für RadioOnkologie und Strahlentherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/22505257?language=en
• 关键词: Reduzierung; der; Unsicherheiten; bei; klinischen

The first German hospital based facility for heavy ion radiotherapy will start its operation in 2007 in Heidelberg. In order to reach the same level of accuracy in radiation dosimetry and dose calculations for treatment planning as is common standard in conventional radiation therapy, a better description of the basic interactions of ions with matter is needed. Since the Heidelberg facility will offer a variety of different ion species (from protons up to oxygen), the basic knowledge gained in the pilot project at GSI for carbon ions interacting with water has to be extended to other ions, but also to target materials other than water. With the help of Monte Carlo simulations, the transport of ion beams through matter will be simulated in detail, taking in to account electronic and nuclear interactions. The questions addressed include the effects of nuclear fragmentation on the response of various dosimeters (emphasizing ionization chambers), dosimeter specific correction factors, differences of ion interactions in various body tissues, improvements in the CT based range calculation and finally a full Monte Carlo based dose calculation for treatment planning.

德国第一个医院重离子放射治疗设施将于2007年在海德堡开始运作。为了达到与常规放射治疗中的常见标准相同的用于治疗计划的辐射剂量测定和剂量计算的准确度水平，需要更好地描述离子与物质的基本相互作用。由于海德堡工厂将提供各种不同的离子种类（从质子到氧气），因此GSI在碳离子与水相互作用的试点项目中获得的基本知识必须扩展到其他离子，而且还要扩展到水以外的目标材料。在蒙特卡罗模拟的帮助下，将详细模拟离子束通过物质的传输，考虑到电子和核相互作用。所解决的问题包括核碎裂对各种剂量计（强调电离室）的响应的影响，剂量计特定的校正因子，在各种身体组织中的离子相互作用的差异，在CT为基础的范围计算的改进，最后一个完整的蒙特卡罗为基础的剂量计算治疗计划。