MRI: Acquisition of a High Resolution/Accurate Orbitrap Mass Spectrometer for Multi-Disciplinary research in the State of New Mexico

新墨西哥州立大学获得了一台Orbitrap聚变质谱仪，将被安置在化学分析和仪器实验室。该仪器是最先进的，用于极端复杂混合物的化学表征，将用于各种各样的应用，从替代燃料研究到疾病研究和基础生物学。该仪器将用于描述复杂混合物的化学成分，以帮助改进生物质栽培和加工成燃料的方式，并将成为包括活细胞成像在内的多个健康相关研究项目的关键组成部分。鉴于该仪器将被广泛应用，这项研究将在该技术的应用中产生新的应用和重大进步。最后，使用Orbitrap Fusion的合作研究项目将为发现提供一个框架，这将提高我们机构招募和留住优秀教师的能力，并将为学生参与科学和工程提供巨大的机会。这次收购的目的是双重的。首先，这次收购将使基于质谱的蛋白质组学能够用于许多合作研究项目。新墨西哥州目前缺乏现代蛋白质组学能力。Orbitrap Fusion仪器架构包括三种正交碎片技术（电子转移解离、碰撞解离和高能碰撞解离）和多重时间离子碎片能力，这些都是现代定量蛋白质组学和蛋白质翻译后修饰分析的关键。其次，对于当前能源、环境和脂质应用领域的多个研究工作，Orbitrap Fusion提供了出色的质量精度，在宽质量范围内的离子传输效率和高分辨率，可以使用碰撞和高能碰撞破碎方法进行复杂混合物分析，以帮助结构阐明。在这些项目区域内，我们将利用Orbitrap Fusion分析生物质热处理和升级的生物油和燃料前体、藻类生长介质和原料、各种生物燃料原料的脂质混合物和复杂的环境样品。

An award is made to New Mexico State University to acquire an Orbitrap Fusion mass spectrometer, to be housed in the Chemical Analysis and Instrumentation Laboratory. This instrumentation is the state-for-the art for chemical characterization of extremely complex mixtures and will be used in a wide variety of applications that range from alternative fuel research to disease research and fundamental biology. This instrument will be used to describe the chemical composition of complex mixtures to help improve the manner in which biomass is cultivated and processed into fuel and will be a key component to multiple health-related research projects including the imaging of live cells. Given the wide range of applications where the instrument will be used, this research will generate both novel applications and significant advancements in the application of this technology. Finally, the collaborative research projects that use the Orbitrap Fusion will provide a framework for discovery that will improve the ability of our institution to recruit and retain excellent faculty and will provide enormous opportunity for student participation in science and engineering. The purpose of this acquisition is twofold. First, this acquisition will enable mass spectrometry-based proteomics for a number of collaborative research projects. Modern proteomic capability is currently absent in the state of New Mexico. The Orbitrap Fusion instrument architecture includes three orthogonal fragmentation techniques (electron transfer dissociation, collisional dissociation and higher energy collisional dissociation) and multiplex-in-time ion fragmentation capability, all of which are critical for modern quantitative proteomics and the analysis of protein post-translational modification. Second, with respect to multiple current research efforts in energy, environment and lipid applications, the Orbitrap Fusion offers excellent mass accuracy, ion transmission efficiency across a broad mass range and high resolving power for complex mixture analysis with collisional and higher energy collisional fragmentation methods to aid structural elucidation. Within those project areas, we will utilize the Orbitrap Fusion for the analysis of bio-oils and fuel precursors from biomass thermotreatment and upgrading, algal growth media and feedstocks, lipid mixtures from various biofuel feedstocks and complex environmental samples.