MRI: Acquisition of a High Resolution/Accurate Orbitrap Mass Spectrometer for Multi-Disciplinary research in the State of New Mexico

新墨西哥州立大学被授予购买Orbitrap Fusion质谱仪的合同，该质谱仪将安装在化学分析和仪器实验室。这种仪器是对极其复杂的混合物进行化学表征的最先进的仪器，将在从替代燃料研究到疾病研究和基础生物学的广泛应用中使用。该仪器将用于描述复杂混合物的化学成分，以帮助改进生物质培养和加工成燃料的方式，并将成为包括活细胞成像在内的多个与健康有关的研究项目的关键组成部分。鉴于该仪器的广泛应用，这项研究将在这项技术的应用方面产生新的应用和重大进展。最后，使用Orbitrap Fusion的合作研究项目将提供一个发现框架，这将提高我们机构招聘和留住优秀教师的能力，并将为学生参与科学和工程提供巨大的机会。此次收购的目的有两个。首先，这项收购将为许多合作研究项目提供基于质谱学的蛋白质组学。新墨西哥州目前缺乏现代蛋白质组能力。Orbitrap Fusion仪器的体系结构包括三种正交碎裂技术(电子转移解离、碰撞解离和高能碰撞解离)和多路时间离子碎裂能力，所有这些都是现代定量蛋白质组学和蛋白质翻译后修饰分析的关键。第二，就目前在能源、环境和脂类应用方面的多项研究工作而言，Orbitrap Fusion提供了出色的质量精度、宽质量范围内的离子传输效率和高分辨率，用于使用碰撞和更高能量的碰撞碎裂方法进行复杂混合物分析，以帮助进行结构解析。在这些项目范围内，我们将利用Orbitrap Fusion分析来自生物质热处理和升级、藻类生长介质和原料、各种生物燃料原料和复杂环境样品的生物油和燃料前体。

An award is made to New Mexico State University to acquire an Orbitrap Fusion mass spectrometer, to be housed in the Chemical Analysis and Instrumentation Laboratory. This instrumentation is the state-for-the art for chemical characterization of extremely complex mixtures and will be used in a wide variety of applications that range from alternative fuel research to disease research and fundamental biology. This instrument will be used to describe the chemical composition of complex mixtures to help improve the manner in which biomass is cultivated and processed into fuel and will be a key component to multiple health-related research projects including the imaging of live cells. Given the wide range of applications where the instrument will be used, this research will generate both novel applications and significant advancements in the application of this technology. Finally, the collaborative research projects that use the Orbitrap Fusion will provide a framework for discovery that will improve the ability of our institution to recruit and retain excellent faculty and will provide enormous opportunity for student participation in science and engineering. The purpose of this acquisition is twofold. First, this acquisition will enable mass spectrometry-based proteomics for a number of collaborative research projects. Modern proteomic capability is currently absent in the state of New Mexico. The Orbitrap Fusion instrument architecture includes three orthogonal fragmentation techniques (electron transfer dissociation, collisional dissociation and higher energy collisional dissociation) and multiplex-in-time ion fragmentation capability, all of which are critical for modern quantitative proteomics and the analysis of protein post-translational modification. Second, with respect to multiple current research efforts in energy, environment and lipid applications, the Orbitrap Fusion offers excellent mass accuracy, ion transmission efficiency across a broad mass range and high resolving power for complex mixture analysis with collisional and higher energy collisional fragmentation methods to aid structural elucidation. Within those project areas, we will utilize the Orbitrap Fusion for the analysis of bio-oils and fuel precursors from biomass thermotreatment and upgrading, algal growth media and feedstocks, lipid mixtures from various biofuel feedstocks and complex environmental samples.