MRI: Acquisition of a High Resolution/Accurate Orbitrap Mass Spectrometer for Multi-Disciplinary research in the State of New Mexico

MRI：为新墨西哥州的多学科研究购买高分辨率/精确的 Orbitrap 质谱仪

• 批准号: 1626468
• 负责人: Tanner Schaub
• 金额: $ 69.91万
• 依托单位: New Mexico State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626468&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Accurate; Orbitrap

An award is made to New Mexico State University to acquire an Orbitrap Fusion mass spectrometer, to be housed in the Chemical Analysis and Instrumentation Laboratory. This instrumentation is the state-for-the art for chemical characterization of extremely complex mixtures and will be used in a wide variety of applications that range from alternative fuel research to disease research and fundamental biology. This instrument will be used to describe the chemical composition of complex mixtures to help improve the manner in which biomass is cultivated and processed into fuel and will be a key component to multiple health-related research projects including the imaging of live cells. Given the wide range of applications where the instrument will be used, this research will generate both novel applications and significant advancements in the application of this technology. Finally, the collaborative research projects that use the Orbitrap Fusion will provide a framework for discovery that will improve the ability of our institution to recruit and retain excellent faculty and will provide enormous opportunity for student participation in science and engineering. The purpose of this acquisition is twofold. First, this acquisition will enable mass spectrometry-based proteomics for a number of collaborative research projects. Modern proteomic capability is currently absent in the state of New Mexico. The Orbitrap Fusion instrument architecture includes three orthogonal fragmentation techniques (electron transfer dissociation, collisional dissociation and higher energy collisional dissociation) and multiplex-in-time ion fragmentation capability, all of which are critical for modern quantitative proteomics and the analysis of protein post-translational modification. Second, with respect to multiple current research efforts in energy, environment and lipid applications, the Orbitrap Fusion offers excellent mass accuracy, ion transmission efficiency across a broad mass range and high resolving power for complex mixture analysis with collisional and higher energy collisional fragmentation methods to aid structural elucidation. Within those project areas, we will utilize the Orbitrap Fusion for the analysis of bio-oils and fuel precursors from biomass thermotreatment and upgrading, algal growth media and feedstocks, lipid mixtures from various biofuel feedstocks and complex environmental samples.

授予新墨西哥州州立大学一项合同，以获得一台轨道阱聚变质谱仪，该质谱仪将安置在化学分析和仪器实验室。 该仪器是最先进的用于极其复杂的混合物的化学表征，并将用于从替代燃料研究到疾病研究和基础生物学的各种应用。该仪器将用于描述复杂混合物的化学成分，以帮助改进生物质的培养和加工成燃料的方式，并将成为多个与健康有关的研究项目的关键组成部分，包括活细胞成像。鉴于该仪器将被广泛应用，这项研究将产生新的应用和该技术应用的重大进步。最后，使用Orbitrap Fusion的合作研究项目将提供一个发现框架，这将提高我们机构招募和留住优秀教师的能力，并将为学生参与科学和工程提供巨大的机会。此次收购的目的是双重的。首先，此次收购将为许多合作研究项目提供基于质谱的蛋白质组学。现代蛋白质组学能力目前在新墨西哥州是缺乏的。Orbitrap Fusion仪器架构包括三种正交裂解技术（电子转移裂解、碰撞裂解和高能碰撞裂解）和多时间离子裂解能力，所有这些对于现代定量蛋白质组学和蛋白质翻译后修饰分析都至关重要。其次，相对于目前在能源、环境和脂质应用方面的多项研究工作，Orbitrap Fusion提供了出色的质量准确性、在宽质量范围内的离子传输效率以及高分辨率，可用于复杂混合物分析，并采用碰撞和高能碰撞碎片方法来辅助结构解析。在这些项目领域，我们将利用Orbitrap Fusion分析生物质热处理和升级中的生物油和燃料前体、藻类生长介质和原料、各种生物燃料原料中的脂质混合物以及复杂的环境样品。