I-Corps Teams: Chromanostics: Minimal-equipment synthetic biology diagnostics

I-Corps 团队：色彩学：最小设备合成生物学诊断

• 批准号: 1632164
• 负责人: Mark Styczynski
• 金额: $ 5万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1632164&HistoricalAwards=false
• 关键词: Corps; Teams; Chromanostics; Minimal; equipment

Vitamin and mineral deficiencies in humans are the cause of millions of deaths annually, primarily in developing nations with limited access to expensive equipment (and in many cases, electricity). Governments and non-government agencies that look to provide aid to address this malnutrition need effective ways to measure which vitamin or mineral deficiencies affect different regions, and which groups of people are most in need of their aid. Currently, measurement of nutrient levels in blood samples is prohibitively expensive for these organizations. In this project, the I-Corps team will confirm the commercial viability of a novel diagnostic test that can measure certain vitamin or mineral levels in human blood, and that can be economically deployed on site in environments with little access to scientific equipment or electricity. The proposed system will provide healthcare workers with information needed to improve and maintain human health.This project will involve customer discovery, market analysis, and the development of a business model related to the proposed innovation. This team intends to interview at least 100 potential customers to better assess the desired characteristics and capabilities of our assay system, and to better define customer segments as well as the characteristics of the desired customer. The team will also strive to better define the market and our competitive advantages, including the unique value proposition. Based on the findings of this research, the team may elect to modify the characteristics of our assay system, to better define target markets, and perhaps more accurately define the proposed project's value proposition and its competitive advantages. The proposed venture, should it be viable, would have a significant impact on nutritional epidemiology work done globally. The proposed technology offers the potential for an order of magnitude reduction in cost, as well as on-site measurement of nutrient levels. Results will be available within a few hours or overnight, compared to the current state of the art which entails refrigerated shipping of samples with a week or more between sampling and receipt of results. The lower cost of this approach places it squarely within the reach of organizations performing nutritional epidemiology work, meaning that populations can be sampled on a meaningful enough scale to allow informed decisions on nutritional interventions. Moreover, this team expects this product to open a new market for nutritional monitoring after interventions; since current measurement costs are so high, tracking the success of a nutritional intervention is not economically viable. The proposed approach could enable tracking that would then allow for scientists and doctors to better understand which of their interventions are working and where, ultimately saving both lives and dollars in the developing world and beyond.

人类缺乏维生素和矿物质是每年数百万人死亡的原因，主要是在获得昂贵设备(在许多情况下，还有电力)有限的发展中国家。寻求提供援助以解决营养不良问题的政府和非政府机构需要有效的方法来衡量哪些维生素或矿物质缺乏影响不同的地区，以及哪些人群最需要他们的援助。目前，对这些组织来说，测量血液样本中的营养水平昂贵得令人望而却步。在这个项目中，i-Corps团队将确认一种新型诊断测试的商业可行性，该测试可以测量人类血液中的某些维生素或矿物质水平，并且可以在几乎没有科学设备或电力的环境中经济地部署在现场。拟议的系统将为医护人员提供改善和维护人类健康所需的信息。该项目将涉及客户发现、市场分析和与拟议创新相关的商业模式的发展。该团队打算采访至少100名潜在客户，以更好地评估我们的检测系统所需的特征和能力，并更好地定义客户群以及所需客户的特征。该团队还将努力更好地定义市场和我们的竞争优势，包括独特的价值主张。基于这项研究的结果，团队可能会选择修改我们的检测系统的特征，以更好地定义目标市场，或许更准确地定义拟议项目的价值主张及其竞争优势。拟议中的合资企业如果可行，将对全球进行的营养流行病学工作产生重大影响。这项拟议的技术提供了将成本降低数量级的潜力，以及对营养水平的现场测量。结果将在几个小时内或一夜之间得到，而目前的技术状态要求样品在采样和收到结果之间需要一周或更长时间的冷藏运输。这种方法的较低成本使其完全可以由执行营养流行病学工作的组织来进行，这意味着可以在足够有意义的规模上对人口进行抽样，以便就营养干预做出明智的决定。此外，该团队预计该产品将为干预后的营养监测打开一个新的市场；由于目前的测量成本如此之高，跟踪营养干预的成功在经济上是不可行的。拟议中的方法可以实现跟踪，从而使科学家和医生能够更好地了解他们的哪些干预措施有效，以及在哪里，最终在发展中国家和其他地区挽救生命和节省资金。