EAGER: NanoEHS Critical Needs - Determining Surface Composition in Biological Media and the Roles of Core Composition and Very Small Particles

EAGER：NanoEHS 关键需求 - 确定生物介质中的表面成分以及核心成分和非常小的颗粒的作用

• 批准号: 1640936
• 负责人: Vicki Grassian
• 金额: $ 3.86万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1640936&HistoricalAwards=false
• 关键词: EAGER; NanoEHS; Critical; Needs; Determining

AbstractCBET - 1424502Vicki H. GrassianOverview:The challenges in understanding the environmental health and safety of nanomaterials (NanoEHS)are many but several fundamental issues in particular remain critical from a scientific perspective.In fact, it has become apparent that progress will be limited without studies to address these issues.Intellectual Merit:This EAGER proposal will address several critical needs in a concentrated program with specific objectives, hypotheses and goals. These critical areas include:1. The nature of the surface of nanomaterials in biological media2. The role of the core in surface functionalized nanoparticles3. The unique behavior imparted to very small nanoparticles that is not just due to physical size but instead due to quantum and other intrinsic size dependent electronic effects.A series of targeted experiments are proposed to address these needs. These experiments are feasible and will provide the necessary results to define a framework to address the issues discussed in this proposal. In these experiments, nanoparticles will be covered using different surface functionalities including proteins. We will conduct these studies in different media relevant to understanding the toxicity of these particles, i.e. several simulated biological media of different pH to reflect both stomach and lung fluids. Furthermore, we can quantify the amount of dissolution and ROS production in each of these and as a function of particlesize, within a size range where quantum confinement is important and outside of that size range where bulk properties of electronic state structure, e.g. the band gap, are relevant.Broader Impacts:There are several broader impacts and translational aspects of the proposed research. First, the proposed studies are designed to gain better insight into the environmental and health impacts of nanomaterials. These studies will contribute to the growing database on the potential environmental and health implications of nanoscience and nanotechnology. This society relevant research is designed to address potential environmental problems for the nanotechnology industry. Therefore overall it has the potential to provide for the greater good of the public and consumers. The proposed activities provide an opportunity to train students in a highly interdisciplinary research area that involves environmental science and engineering, chemistry, nanoscience, colloid and surface chemistry. The PI has a track record of successfully mentoring students at all levels from high school to postdoctoral associates and visiting research scientists and will continue this effort to mentor the next generation of scientists and engineers. Many of the students are from underrepresented groups in science and engineering including a large percentage of women (more than 60%) and minorities including students on free and reduced lunch programs and typically more diverse student populations. Funds from this NSFgrant will be used to train graduate and undergraduate students to better engage these elementary students as well as the public in science and engineering.

摘要：概述：理解纳米材料（NanoEHS）的环境健康和安全的挑战很多，但从科学的角度来看，几个基本问题尤其重要。事实上，很明显，如果不研究解决这些问题，进展将受到限制。智力优势：这个EAGER提案将在一个具有特定目标、假设和目标的集中项目中解决几个关键需求。这些关键领域包括：1。生物介质中纳米材料表面的性质核在表面功能化纳米颗粒中的作用赋予非常小的纳米颗粒的独特行为，不仅是由于物理尺寸，而是由于量子和其他固有尺寸相关的电子效应。提出了一系列有针对性的实验来满足这些需求。这些实验是可行的，并将提供必要的结果，以确定解决本提案中讨论的问题的框架。在这些实验中，纳米粒子将被不同的表面功能覆盖，包括蛋白质。我们将在不同的介质中进行这些研究，以了解这些颗粒的毒性，即几种不同pH值的模拟生物介质，以反映胃和肺的液体。此外，我们可以量化每一种情况下的溶解量和ROS产生量，并将其作为颗粒的函数，在量子限制很重要的尺寸范围内，在电子态结构的体积性质（例如带隙）相关的尺寸范围之外。更广泛的影响：提出的研究有几个更广泛的影响和转化方面。首先，拟议的研究旨在更好地了解纳米材料对环境和健康的影响。这些研究将有助于建立关于纳米科学和纳米技术对环境和健康潜在影响的日益增长的数据库。这项与社会相关的研究旨在解决纳米技术工业潜在的环境问题。因此，总的来说，它有潜力为公众和消费者提供更大的利益。拟议的活动提供了一个机会，培养学生在一个高度跨学科的研究领域，涉及环境科学与工程，化学，纳米科学，胶体和表面化学。PI在成功指导从高中到博士后助理和访问研究科学家的各个层次的学生方面有着良好的记录，并将继续努力指导下一代科学家和工程师。许多学生来自代表性不足的科学和工程群体，包括很大比例的女性（超过60%）和少数民族，包括免费和减少午餐计划的学生，以及通常更多样化的学生群体。该基金将用于培养研究生和本科生，使这些小学生以及公众更好地参与科学和工程。