Vascular Tissue Road-mapping Workshop & Micro-gravity Impact Roundtable

血管组织路线图研讨会

• 批准号: 1642055
• 负责人: Joshua Neubert
• 金额: $ 2万
• 依托单位: The Methuselah Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1642055&HistoricalAwards=false
• 关键词: Vascular; Tissue; Road; mapping; Workshop

1642055 - NeubertNSF has made an award in support of participant travel costs and management costs associated with the "Vascular Tissue Road-mapping Workshops & Micro-gravity Impact Roundtable" being held in the Mountain View, CA, at the NASA Ames Research Center, August 20, 2016. The proposal builds upon a previous 2015 NSF BME funded workshop in which a Roadmap was created identifying pathways, milestones, and challenges toward ending the organ shortage. This workshop focuses on one of the identified milestones, "thick-tissue vascularization," which has led to NASA's launch of a "Vascular Tissue Challenge" with a $500,000 prize purse provided to the first research groups that can successfully vascularize 1 cm thick tissues with active parenchymal cells (liver, lung, heart, muscle, kidney cells.) Though much is known about possible techniques, very little is known about the possible enabling benefits of microgravity. The workshop will provide the research community pursuing this vascularization goal an opportunity to better understand the milestones along this pathway and learn more about possible enabling opportunities.The workshop will be conducted in 3 parts: 1) a Vascular Tissue Road-mapping session, 2) a Vascular Tissue Challenge Team Summit, and 3) a Roundtable on the micro-gravity environment's impact on tissue engineering. Outputs expected include: 1) A Road-mapping Report on the Vascularization Pathway towards solutions to the organ shortage that will include identification and descriptions of specific milestones and challenges along this pathway of mutual interest to the research and funding communities; 2) A White Paper on the current state of the art in thick-tissue vascularization; 3) A White Paper on available resources and opportunities for research groups pursuing thick-tissue vascularization and 4) A White Paper on the current state of knowledge about the impacts of micro-gravity on thick-tissue vascularization. Keynote speakers and participants will be curated through the Vascular Tissue Challenge team roster, existing New Organ Advisory Board members and the thick-tissue vascularization research community. The workshop is expected to leverage new relationships for additional prizes and challenges on the bioengineering pathways toward ending the organ shortage. Ultimately, the worship will help advance the goal of making regenerated, engineered organs and tissues available to patients who need them.

1642055-2016年8月20日，诺贝特国家科学基金会在美国国家航空航天局艾姆斯研究中心的山景城颁发了一个奖项，以支持参与者的旅行费用和与“血管组织道路测绘研讨会和微重力影响圆桌会议”相关的管理费用。该提案建立在2015年由NSF BME资助的研讨会的基础上，在研讨会上创建了路线图，确定了结束器官短缺的途径、里程碑和挑战。本次研讨会的重点是“厚组织血管化”这一已确定的里程碑之一，它导致NASA发起了一项“血管组织挑战”，并向首批研究小组提供50万美元的奖金，这些研究小组可以成功地将1厘米厚的组织与活跃的实质细胞(肝、肺、心脏、肌肉和肾脏细胞)血管化。虽然人们对可能的技术了解很多，但对微重力可能带来的好处却知之甚少。研讨会将为追求这一血管化目标的研究团体提供一个机会，以更好地了解这条道路上的里程碑，并了解更多可能的促进机会。研讨会将分三部分进行：1)血管组织路线图会议，2)血管组织挑战团队峰会，3)微重力环境对组织工程的影响圆桌会议。预计的产出包括：1)关于解决器官短缺的血管形成路径的路线图报告，其中将包括确定和描述这条路径上的具体里程碑和研究和资助界共同感兴趣的挑战；2)关于厚组织血管形成技术现状的白皮书；3)关于研究小组寻求厚组织血管形成的可用资源和机会的白皮书；4)关于微重力对厚组织血管形成影响的知识现状的白皮书。主旨演讲者和参与者将通过血管组织挑战团队花名册、现有的新器官咨询委员会成员和厚组织血管形成研究社区进行策划。研讨会预计将利用新的关系，在结束器官短缺的生物工程途径上获得更多奖励和挑战。最终，崇拜将有助于推进使再生的、工程化的器官和组织提供给需要它们的患者的目标。