2016 Barriers of the CNS Gordon Research Conference & Gordon Research Seminar

2016 CNS 戈登研究会议的障碍

• 批准号: 9193309
• 负责人: ROBERT GARY THORNE
• 金额: $ 2.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9193309
• 关键词: Address; Area; Astrocytes; Biological Models; Blood - brain barrier anatomy; Blood Vessels; Blood-Retinal Barrier; Brain; Brain Diseases; Cells; Central Nervous System Agents; Central Nervous System Diseases; Clinic; Country; Development; Diagnosis; Discipline; Disease; Drug Delivery Systems; Endothelial Cells; Environment; Faculty; Feedback; Functional disorder; Funding; Future; Goals; Growth and Development function; Health; Human; Immune; Immunology; Industry; International; Learning; Malignant neoplasm of brain; Mentors; Mentorship; Methods; Modeling; Molecular; Nervous system structure; Neuraxis; Neurodegenerative Disorders; Neurons; New Hampshire; Pathology; Pericytes; Pharmacotherapy; Postdoctoral Fellow; Prevention; Property; Regulation; Request for Applications; Request for Proposals; Research; Research Personnel; Rest; Science; Scientist; Signal Transduction; Staging; Stroke; Structure; Students; System; Tight Junctions; Traumatic Brain Injury; abstracting; blood cerebrospinal fluid barrier; college; design; drug discovery; drug distribution; graduate student; imaging system; improved; industry partner; insight; lectures; meetings; nervous system disorder; neurovascular; neurovascular unit; novel; novel strategies; posters; prevent; programs; symposium

Project Summary / Abstract This proposal requests support for partial funding of the 2016 `Barriers of the Central Nervous System (CNS)' GRC and GRS that will be held at Colby Sawyer College, New Hampshire, on June 18 – 19, 2016 (GRS) and June 19 – 24, 2016 (GRC). The overall goal of this international conference is to increase understanding of the basic mechanisms underlying the structure and function of CNS barriers in health and disease. The 2016 meeting will present cutting-edge research and provide new perspectives on all aspects of CNS barriers science. Concepts surrounding the neurovascular unit and major barrier systems such as the blood-brain barrier (BBB), blood-cerebrospinal fluid barriers and blood-retinal barriers will be comprehensively explored in featured talks and daily poster sessions. Specific themes for the meeting will cover key aspects of the CNS barriers including transporters, the effects of neurological disorders and disease, immunology, novel methods, drug delivery, and the future of the field. The program will include 2 opening keynote lectures on new perspectives associated with unique CNS vascular niches and neurovascular regulation and dysfunction in disease states as well as a final keynote lecture on challenges and opportunities associated with academic/industrial partnerships in CNS barriers science. An additional 8 sessions will address the following specific topics: transport, signaling and junctions at the CNS barriers and beyond; barrier function in stroke and brain trauma; barrier function in neurodegenerative disease and brain cancer; immunology of the CNS barriers and related systems; imaging and model systems; CNS drug delivery and distribution; and evolving perspectives on how to maximize partnerships among and between academic and industry groups and promote collaborative science in the field. The Barriers GRC fills a critical niche which otherwise does not exist among other major international and national conferences to bring together scientists and clinicians from diverse fields and countries for a focused meeting on the CNS barriers, expanding understanding of key issues ranging from molecular mechanisms to drug delivery. The preceding 2-day “Barriers” GRS is organized by junior investigators at the postdoctoral level and is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the field's methods and issues and to facilitate networking and provide mentorship opportunities. This GRC is focused on the highly translational area of CNS barriers science. This application has a significant relationship to health, in that the presentations and discussions will expand our understanding of all aspects of the CNS barriers, including their development and altered function in CNS diseases. The insights gained will facilitate significant future progress in our appreciation of the barriers and what factors regulate them, stimulate the development of new applications extending from models to human beings, and, importantly, identify novel strategies to improve the diagnosis, prevention, and treatment of neurological disorders.

项目概要/摘要 该提案要求为 2016 年“中枢神经障碍”项目提供部分资助 System (CNS) 的 GRC 和 GRS 将于 6 月 18 日至 19 日在新罕布什尔州 Colby Sawyer 学院举行 2016 年（GRS）和 2016 年 6 月 19 日至 24 日（GRC）。本次国际会议的总体目标是 了解健康和中枢神经系统屏障结构和功能的基本机制 疾病。 2016年的会议将展示前沿研究并提供各方面的新视角 中枢神经系统障碍科学。围绕神经血管单元和主要屏障系统的概念，例如 血脑屏障（BBB）、血脑脊液屏障、血视网膜屏障将全面 在专题演讲和每日海报会议中进行探讨。会议的具体主题将涵盖以下关键方面 中枢神经系统屏障，包括转运蛋白、神经系统紊乱和疾病的影响、免疫学、新颖 方法、药物输送和该领域的未来。 该计划将包括 2 场开幕主题演讲，内容涉及与独特的中枢神经系统相关的新观点 疾病状态下的血管生态位和神经血管调节和功能障碍以及最后的主题演讲 关于中枢神经系统障碍中学术/工业合作伙伴关系的挑战和机遇的讲座 科学。另外 8 场会议将讨论以下具体主题：交通、信号和路口 中枢神经系统障碍及其他障碍；中风和脑外伤中的屏障功能；神经退行性疾病中的屏障功能 疾病和脑癌；中枢神经系统屏障和相关系统的免疫学；成像和模型系统； 中枢神经系统药物输送和分配；以及关于如何最大限度地扩大彼此之间的伙伴关系的不断变化的观点 学术界和工业界之间的合作，促进该领域的科学合作。 Barriers GRC 填补了其他主要国际组织中不存在的关键利基市场 和全国会议，将来自不同领域和国家的科学家和临床医生聚集在一起，共同探讨 会议重点讨论中枢神经系统障碍，扩大对分子等关键问题的理解 药物输送机制。之前为期 2 天的“障碍”GRS 由初级调查员在 博士后级别，旨在引进年轻科学家（研究生、博士后、初级科学家） 教师）了解该领域的方法和问题，并促进建立联系并提供指导机会。 该 GRC 专注于中枢神经系统屏障科学的高度转化领域。这个应用程序有一个 与健康的重要关系，因为演示和讨论将扩大我们对所有 中枢神经系统障碍的各个方面，包括它们在中枢神经系统疾病中的发展和功能改变。见解 所取得的成果将有助于我们在了解障碍和调节因素方面取得重大进展 它们刺激了从模型到人类的新应用的开发，而且重要的是， 确定改善神经系统疾病的诊断、预防和治疗的新策略。