2016 Barriers of the CNS Gordon Research Conference & Gordon Research Seminar

项目总结/摘要 该提案要求支持2016年"中枢神经障碍“项目的部分资金 系统（CNS）的GRC和GRS将于6月18日至19日在新罕布什尔州的科尔比索耶学院举行， 2016年（GRS）和2016年6月19 - 24日（GRC）。本次国际会议的总体目标是增加 了解健康中CNS屏障的结构和功能的基本机制， 疾病2016年的会议将提出前沿研究，并提供有关各方面的新观点， CNS屏障科学。围绕神经血管单位和主要屏障系统的概念， 血-脑屏障（BBB）、血-脑脊液屏障和血-视网膜屏障将被全面研究。 在专题讲座和每日海报会议中探索。会议的具体主题将涵盖以下主要方面： CNS屏障包括转运蛋白，神经障碍和疾病的影响，免疫学，新的 方法，药物输送和该领域的未来。 该计划将包括2个开幕主题演讲的新观点与独特的中枢神经系统 血管壁龛和神经血管调节和疾病状态的功能障碍，以及最后的基调 学术界/工业界在CNS障碍方面的伙伴关系所带来的挑战和机遇讲座 科学另外8节课将讨论以下特定主题：交通，信号和路口 中枢神经系统屏障及其他;中风和脑创伤中的屏障功能;神经退行性疾病中的屏障功能 疾病和脑癌; CNS屏障和相关系统的免疫学;成像和模型系统; 中枢神经系统药物的输送和分配;以及关于如何最大限度地扩大 学术界和工业界之间的合作，并促进该领域的合作科学。 Barriers GRC填补了一个关键的利基市场，否则在其他主要国际 和国家会议，汇集来自不同领域和国家的科学家和临床医生， 集中讨论CNS屏障，扩大对关键问题的理解， 药物输送的机制。前两天的“障碍”调查由初级调查员在 博士后水平，旨在引进年轻的科学家（研究生，博士后，初级 教师）的领域的方法和问题，并促进网络和提供导师的机会。 该GRC专注于CNS屏障科学的高度转化领域。此应用程序具有 与健康的重要关系，因为演讲和讨论将扩大我们对所有人的理解， CNS屏障的各个方面，包括它们在CNS疾病中的发展和功能改变。的见解 获得的信息将有助于我们在理解障碍和调节因素方面取得重大进展 它们，刺激了从模型到人类的新应用程序的开发，而且，重要的是， 确定新的策略，以改善神经系统疾病的诊断，预防和治疗。

Project Summary / Abstract This proposal requests support for partial funding of the 2016 `Barriers of the Central Nervous System (CNS)' GRC and GRS that will be held at Colby Sawyer College, New Hampshire, on June 18 – 19, 2016 (GRS) and June 19 – 24, 2016 (GRC). The overall goal of this international conference is to increase understanding of the basic mechanisms underlying the structure and function of CNS barriers in health and disease. The 2016 meeting will present cutting-edge research and provide new perspectives on all aspects of CNS barriers science. Concepts surrounding the neurovascular unit and major barrier systems such as the blood-brain barrier (BBB), blood-cerebrospinal fluid barriers and blood-retinal barriers will be comprehensively explored in featured talks and daily poster sessions. Specific themes for the meeting will cover key aspects of the CNS barriers including transporters, the effects of neurological disorders and disease, immunology, novel methods, drug delivery, and the future of the field. The program will include 2 opening keynote lectures on new perspectives associated with unique CNS vascular niches and neurovascular regulation and dysfunction in disease states as well as a final keynote lecture on challenges and opportunities associated with academic/industrial partnerships in CNS barriers science. An additional 8 sessions will address the following specific topics: transport, signaling and junctions at the CNS barriers and beyond; barrier function in stroke and brain trauma; barrier function in neurodegenerative disease and brain cancer; immunology of the CNS barriers and related systems; imaging and model systems; CNS drug delivery and distribution; and evolving perspectives on how to maximize partnerships among and between academic and industry groups and promote collaborative science in the field. The Barriers GRC fills a critical niche which otherwise does not exist among other major international and national conferences to bring together scientists and clinicians from diverse fields and countries for a focused meeting on the CNS barriers, expanding understanding of key issues ranging from molecular mechanisms to drug delivery. The preceding 2-day “Barriers” GRS is organized by junior investigators at the postdoctoral level and is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the field's methods and issues and to facilitate networking and provide mentorship opportunities. This GRC is focused on the highly translational area of CNS barriers science. This application has a significant relationship to health, in that the presentations and discussions will expand our understanding of all aspects of the CNS barriers, including their development and altered function in CNS diseases. The insights gained will facilitate significant future progress in our appreciation of the barriers and what factors regulate them, stimulate the development of new applications extending from models to human beings, and, importantly, identify novel strategies to improve the diagnosis, prevention, and treatment of neurological disorders.