EAGER/Collaborative Research: Sensing, Modeling and Optimization of Postoperative Heart Health Management

EAGER/合作研究：术后心脏健康管理的传感、建模和优化

• 批准号: 1646660
• 负责人: Hui Yang
• 金额: $ 17.2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1646660&HistoricalAwards=false
• 关键词: EAGER; Collaborative; Research; Sensing; Modeling

Postoperative outcomes are critical to the quality of life of many patients. However, after discharge, there are currently few sensor-based decision support systems extending to home, workplace, and community. Postoperative care primarily depends on episodic follow-up visits and rare electrocardiograms. Very little has been done to continuously monitor clinical parameters of postoperative patients, estimate clinical status, and further help optimal management of postoperative recovery. This EArly-concept Grant for Exploratory Research (EAGER) award supports fundamental research to develop a collaborative sensing, statistical modeling and decision-making strategy for optimizing postoperative management of heart health. This research will help clinicians and patients leverage the fast development of sensing and mobile technology to achieve a substantial boost in smart postoperative management. As a result, this project will provide education on heart-healthy living and raise the awareness of smart health. In addition, realizing a better postoperative care will achieve a reduction in healthcare costs. A broader impact in education will be realized through new curriculum modules, training of healthcare professionals, and recruitment of under-represented students.In current practice, ad hoc strategies are widely used for managing postoperative risks. This award will make possible a new sensor-based, patient-centered management of heart health that can overcome several limitations of existing practices. In particular, it will empower clinicians and patients to (1) quantitatively measure the quality of life before and after cardiac procedures, (2) optimize postoperative cardiac care and decrease arrhythmia recurrences, and (3) improve lifestyle modifications and positively influence general postoperative outcomes. If successful, this research will lead to new data imputation algorithms to tackle uncertainty in patient-centered sensing, extract sensor-based biomarkers of cardiac risks, model the evolving dynamics of cardiac conditions, and optimize postoperative management under uncertainty. The success of this project will invoke a new "sensing-modeling-optimization" approach to theoretically formulate relationships connecting physiological signals from postoperative patients, useful information from analytical models with smart postoperative health management. Analytical methods and tools will be generally applicable to handle data veracity, feature extraction, risk prognostics, and process optimization in sensor-based monitoring and control of cardiovascular systems.

术后结局对许多患者的生活质量至关重要。 然而，在出院后，目前很少有基于传感器的决策支持系统延伸到家庭，工作场所和社区。术后护理主要依赖于间歇性随访和罕见的心电图。几乎没有做任何工作来连续监测术后患者的临床参数，估计临床状态，并进一步帮助术后恢复的最佳管理。EARLY概念探索性研究资助（EAGER）奖支持基础研究，以开发协作传感，统计建模和决策策略，以优化心脏健康的术后管理。 这项研究将帮助临床医生和患者利用传感和移动的技术的快速发展，实现智能术后管理的实质性推动。 因此，该项目将提供有关心脏健康生活的教育，并提高对智能健康的认识。 此外，实现更好的术后护理将降低医疗成本。 通过新的课程模块，医疗保健专业人员的培训，以及招募代表性不足的学生，将在教育方面产生更广泛的影响。在目前的实践中，临时策略被广泛用于管理术后风险。 该奖项将使一种新的基于传感器的、以患者为中心的心脏健康管理成为可能，这种管理可以克服现有实践的几个局限性。特别是，它将使临床医生和患者能够（1）定量测量心脏手术前后的生活质量，（2）优化术后心脏护理并减少心律失常复发，以及（3）改善生活方式的改变并积极影响一般术后结局。 如果成功，这项研究将导致新的数据填补算法，以解决以患者为中心的传感中的不确定性，提取基于传感器的心脏风险生物标志物，模拟心脏状况的动态变化，并在不确定性下优化术后管理。该项目的成功将调用一种新的“感知-建模-优化”方法，从理论上制定连接术后患者生理信号的关系，从分析模型中获得有用信息，并进行智能术后健康管理。分析方法和工具通常适用于处理心血管系统基于传感器的监测和控制中的数据准确性、特征提取、风险预测和过程优化。

项目成果

Mesh resolution impacts the accuracy of inverse and forward ECG problems

网格分辨率影响逆向和正向心电图问题的准确性

• DOI: 10.1109/embc.2016.7591615
• 发表时间: 2016
• 期刊: Proceedings of 2016 IEEE Engineering in Medicine and Biology Society Conference (EMBC
• 作者: Yao, Bing;Pei, Shenli;Yang, Hui
• 通讯作者: Yang, Hui

Inverse ECG modeling with spatiotemporal regularization for the characterization of myocardial infarctions

具有时空正则化的逆心电图建模用于表征心肌梗死

• DOI: 10.1109/bhi.2018.8333384
• 发表时间: 2018
• 期刊: Proceedings of the 2018 IEEE International Conference on Biomedical and Health Informatics (BHI
• 作者: Yao, Bing;Zhu, Rui;Yang, Hui
• 通讯作者: Yang, Hui

In-Silico Modeling of the Functional Role of Reduced Sialylation in Sodium and Potassium Channel Gating of Mouse Ventricular Myocytes

• DOI: 10.1109/jbhi.2017.2664579
• 发表时间: 2018-03-01
• 期刊: IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
• 影响因子: 7.7
• 作者: Du, Dongping;Yang, Hui;Bennett, Eric S.
• 通讯作者: Bennett, Eric S.

Heterogeneous recurrence analysis of heartbeat dynamics for the identification of sleep apnea events

• DOI: 10.1016/j.compbiomed.2016.05.006
• 发表时间: 2016-08-01
• 期刊: COMPUTERS IN BIOLOGY AND MEDICINE
• 影响因子: 7.7
• 作者: Cheng, Changqing;Kan, Chen;Yang, Hui
• 通讯作者: Yang, Hui

Characterizing the Location and Extent of Myocardial Infarctions With Inverse ECG Modeling and Spatiotemporal Regularization

• DOI: 10.1109/jbhi.2017.2768534
• 发表时间: 2018-09
• 期刊: IEEE Journal of Biomedical and Health Informatics
• 影响因子: 7.7
• 作者: B. Yao;Rui Zhu;Hui Yang