EAGER: Microfluidic-based device to transform the T cell manufacturing process for adoptive T cell therapy
EAGER:基于微流体的设备,可改变过继性 T 细胞疗法的 T 细胞制造工艺
基本信息
- 批准号:1649243
- 负责人:
- 金额:$ 28.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The National Science Foundation uses the Early-concept Grants for Exploratory Research (EAGER) funding mechanism to support exploratory work in its early stages on untested, but potentially transformative, research ideas or approaches. This EAGER project was awarded as a result of the invitation in the Dear Colleague Letter NSF 16-080 to proposers from Historically Black Colleges and Universities to submit proposals that would strengthen research capacity of faculty at the institution. The project at North Carolina A&T State University (NC A&T) aims to manufacture T cells for cancer immunotherapy. The purpose of this study is to gain a clear understanding of the T cell manufacturing process and identify factors critical for inducing the T cell necessary for effective tumor destruction, thus transforming the treatment of cancer. This project will provide students with cutting-edge adoptive immunotherapy technologies, build strong expertise in bio-manufacturing, a first at NC A&T, and promote economic development through innovation and creation of new knowledge to position NC A&T as a significant player in biomedical engineering research and education.The goal of this proposal is to develop an integrated microfluidic bioreactor which can rapidly manufacture T cells through sequential separation, activation, and expansion. The specific objectives are to: 1) develop a microfluidic system to separate specific T cells from blood; and 2) develop a microfluidic bioreactor to activate and expand T cells and characterize the functional phenotype of T cells by measuring surface markers and cytokine release. This system has the potential to: 1) generate key knowledge of T cell dysregulation and efficacy of immune therapies; 2) advance cancer treatment using tumor- and patient-specific T cell manufacturing; and 3) radically change our understanding of the T cell manufacturing process. This integrated microfluidic system will be at the forefront of the next frontier in cancer immunotherapy.This EAGER project is funded by the Directorate for Engineering and the Directorate for Education and Human Resources.
美国国家科学基金会使用探索性研究早期概念赠款(EAGER)资助机制,以支持未经测试但可能具有变革性的研究想法或方法的早期阶段的探索性工作。EAGER项目是由于在亲爱的同事信NSF 16-080中邀请来自历史上黑人学院和大学的提议者提交提案,以加强该机构教师的研究能力而获得的。北卡罗来纳州A T州立大学(NC A T)的这个项目旨在制造用于癌症免疫治疗的T细胞。本研究的目的是清楚地了解T细胞的制造过程,并确定诱导有效破坏肿瘤所需的T细胞的关键因素,从而改变癌症的治疗。该项目将为学生提供最先进的过继免疫治疗技术,建立强大的生物制造专业知识,这是NC A T的第一个,并通过创新和创造新知识来促进经济发展,使NC A T成为生物医学工程研究和教育的重要参与者。该项目的目标是开发一种集成的微流体生物反应器,可以通过连续分离,活化和扩增快速制造T细胞。具体目标是:1)开发一种微流控系统,从血液中分离特定的T细胞; 2)开发一种微流控生物反应器,通过测量表面标志物和细胞因子释放来激活和扩增T细胞并表征T细胞的功能表型。该系统有潜力:1)产生T细胞失调和免疫疗法功效的关键知识; 2)使用肿瘤和患者特异性T细胞制造推进癌症治疗; 3)从根本上改变我们对T细胞制造过程的理解。这种集成的微流体系统将处于癌症免疫治疗的下一个前沿。EAGER项目由工程局和教育和人力资源局资助。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening
- DOI:10.1371/journal.pone.0224657
- 发表时间:2019-11-08
- 期刊:
- 影响因子:3.7
- 作者:Liu, Lumei;Koo, Youngmi;Yun, Yeoheung
- 通讯作者:Yun, Yeoheung
Assessment of Cytotoxicity of Magnesium Oxide and Magnesium Hydroxide Nanoparticles using the Electric Cell-Substrate Impedance Sensing
使用电池-基底阻抗传感评估氧化镁和氢氧化镁纳米颗粒的细胞毒性
- DOI:10.3390/app10062114
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Pallavi, Manishi;Waterman, Jenora;Koo, Youngmi;Sankar, Jagannathan;Yun, Yeoheung
- 通讯作者:Yun, Yeoheung
Three-dimensional brain-on-chip model using human iPSC-derived GABAergic neurons and astrocytes: Butyrylcholinesterase post-treatment for acute malathion exposure
- DOI:10.1371/journal.pone.0230335
- 发表时间:2020-03-12
- 期刊:
- 影响因子:3.7
- 作者:Liu, Lumei;Koo, Youngmi;Yun, Yeoheung
- 通讯作者:Yun, Yeoheung
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Yeoheung Yun其他文献
SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE
南方生物医学工程大会
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Yeoheung Yun - 通讯作者:
Yeoheung Yun
A surface-eroding poly(1,3-trimethylene carbonate) coating for fully-biodegradable magnesium-based stent applications: toward better biofunction, biodegradation, and biocompatibilit.
用于完全生物降解镁基支架应用的表面侵蚀聚(1,3-三亚甲基碳酸酯)涂层:实现更好的生物功能、生物降解和生物相容性。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:9.7
- 作者:
Juan Wang;Yonghui He;Manfred F. Maitz;Boyce Collins;Kaiqin Xiong;Lisha Guo;Yeoheung Yun;Guojiang Wan;Nan Huang - 通讯作者:
Nan Huang
Free-standing carbon nanotube–titania photoactive sheets
- DOI:
10.1016/j.jcis.2015.02.022 - 发表时间:
2015-06-15 - 期刊:
- 影响因子:
- 作者:
Youngmi Koo;Rachit Malik;Noe Alvarez;Vesselin N. Shanov;Mark Schulz;Jag Sankar;Yeoheung Yun - 通讯作者:
Yeoheung Yun
Yeoheung Yun的其他文献
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{{ truncateString('Yeoheung Yun', 18)}}的其他基金
Excellence in Research: Human Stem Cell-Derived Polarized Dorsoventral Forebrain Organoid: Effect of Matrix Stiffness and Mechanical Stimulus
卓越研究:人类干细胞衍生的极化背腹前脑类器官:基质硬度和机械刺激的影响
- 批准号:
2100987 - 财政年份:2021
- 资助金额:
$ 28.62万 - 项目类别:
Standard Grant
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基于RPA-microfluidic chip技术高效诊断侵袭性真菌病的研究
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利用Microfluidic系统研究血流速度对巨核细胞生成血小板的信号调控机制
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