CAREER: OP: Ultraviolet Superchiral Light-Matter Interactions: Plasmonic Devices for Enhanced Structural Biology Characterization

职业：OP：紫外超手性光-物质相互作用：用于增强结构生物学表征的等离子体装置

• 批准号: 1653705
• 负责人: Kevin McPeak
• 金额: $ 50万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1653705&HistoricalAwards=false
• 关键词: CAREER; OP; Ultraviolet; Superchiral; Light

Title: CAREER: Superchiral Light-Matter Interactions: Plasmonic Devices for Enhanced Structural Biology CharacterizationAbstractNon-Technical: The human hand is perhaps the best example of a chiral object. Chiral objects cannot be overlaid on their mirror image and are fundamental to life itself. For example, amino acids are left handed and sugars are right handed. Light can also be chiral having either a left- or right-handed twist. Twisted light can interact or "shake hands" with chiral matter offering a rapid, non-invasive method for characterizing the structure of biomolecules. The first goal of this project is to advance the understanding of chiral light-matter interactions, enabling devices that can rapidly identify Parkinson's and Alzheimer's diseases and advance the search for cures. The second goal of this project is to engage 3rd grade and high school students in science and engineering research through videos and mini-courses related to polarized light. Beyond these efforts, this project will directly benefit graduate and undergraduate researchers through mentoring; and more broadly, K-12 students with interests in polarized light-matter interactions.Technical: Chiral objects, i.e. not superimposable on their mirror image, exhibit optical activity which manifest in circular birefringence and circular dichroism i.e., the difference in the refractive indices and absorption for left and right circularly polarized light (CPL), respectively. Structural biologist have long pursued these chiral light-matter interactions to understand the structure-function relationship in proteins. Unfortunately, traditional optical characterization methods provide low-resolution structural information primarily due to the large size mismatch between biomolecules and the wavelength of light. Nanostructured plasmonic devices can generate superchiral near-fields, which provide highly twisted light i.e., over 100 times that of CPL, confined in sub-diffraction limited volumes. Through this program, the PI will investigate superchiral light-matter interactions between fabricated plasmonic devices and biomolecules. This research will explore the energy and spatial overlap between plasmonic resonances and biomolecules in an effort to maximize the enhancement of the far-field chiroptical spectra of the biomolecule. These studies are expected to expand our understanding of superchiral light-matter interactions and lead to a new class of plasmonic devices including those used in early detection of degenerative diseases and drug design for their treatments.

标题：职业：超级亮点相互作用：增强结构生物学表征的等离子体设备abstractnon-technical：人的手可能是手性对象的最好例子。手性物体不能被覆盖在其镜像上，并且是生命本身的基础。例如，将氨基酸左手右手右手右手。光也可以是手性，具有左手或右手的扭曲。扭曲的光可以与手性质相互作用或“握手”，提供一种表征生物分子结构的快速，无创方法。该项目的第一个目标是提高人们对手性光 - 物质相互作用的理解，从而使可以迅速识别帕金森氏症和阿尔茨海默氏症疾病的设备，并提高搜索治疗方法。该项目的第二个目标是通过与偏光光相关的视频和迷你演奏来与三年级和高中生一起参与科学和工程研究。除了这些努力之外，该项目还将通过指导直接使研究生和本科研究人员受益；更广泛地说，具有对两极分化光的相互作用感兴趣的K-12学生。技术：手性物体，即不可叠加在镜像上，表现出光学活动，表现为圆周双发性二色性和圆形二色性，即，左右圆形极光的折射率和吸收的差异，分别是左右的（c）。结构生物学家长期以来一直追求这些手性光 - 物质相互作用，以了解蛋白质中的结构功能关系。不幸的是，传统的光学特征方法提供了低分辨率的结构信息，这主要是由于生物分子与光的波长之间的较大尺寸不匹配。纳米结构的等离子设备可以生成超级近后近场，从而提供高度扭曲的光，即CPL的100倍，限制为限制的量。通过该程序，PI将研究制造的等离子设备和生物分子之间的超细光物质相互作用。这项研究将探讨等离子共振和生物分子之间的能量和空间重叠，以最大程度地增强生物分子的远场手柄光谱。预计这些研究将扩大我们对超细光结合相互作用的理解，并导致一类新的等离子设备，包括用于早期发现退行性疾病和药物设计的等离子设备。

项目成果

Correlation of circular differential optical absorption with geometric chirality in plasmonic meta-atoms

等离子体元原子中圆形微分光吸收与几何手性的相关性

• DOI: 10.1364/oe.27.005097
• 发表时间: 2019
• 期刊: Optics Express
• 影响因子: 3.8
• 作者: Wilson, Jon C.;Gutsche, Philipp;Herrmann, Sven;Burger, Sven;McPeak, Kevin M.
• 通讯作者: McPeak, Kevin M.