Collaborative Research: cis-Regulatory Basis of Butterfly Wing Pattern Evolution
合作研究:蝴蝶翅膀图案进化的顺式调控基础
基本信息
- 批准号:1656553
- 负责人:
- 金额:$ 31.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-15 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Non-technical descriptionUnderstanding the formation of color patterns has long played a central theme in understanding biology. Butterfly wing color patterns represent a prime model to explore the history, genes, and mechanisms underlying wing patterning. A single gene (WntA) drives shape changes across the wing surface in many distantly related species, thus suggesting a fundamental and ancestral function in butterfly wing formation. The research team from the University of Puerto Rico, George Washington University, and Cornell University will investigate the gene changes underlying distribution of pigmentation across the wing surface among a variety of butterfly species. The goal of the study is to determine how WntA has acquired the ability to control diverse wing displays across multiple time scales. This study will set the foundation for understanding the interplay between gene regulation and diversity of form. Technical descriptionThis study aims to determine how gene regulatory architecture evolves in concert with an adaptive trait over different time scales. The research team will specifically focus on characterizing the regulatory mechanisms underlying the repeated role of the signaling ligand WntA in wing pattern evolution. This work will address how the modulation of WntA spatial expression has tinkered with the micro- and macroevolution of distinct wing phenotypes across 65 million years. We will specifically aim to address the following questions: (1) How many regulatory elements at a single gene control wing pattern variation, and what are the function of individual elements? (2) Do the same elements also control the convergent evolution of mimetic phenotypes in unrelated species? (3) To what extent are wing pattern CREs conserved versus novel across species with highly divergent wing patterns? Answering these questions will help set a precedent for understanding deeper phylogenetic patterns in the relationship between the evolution of CREs and the traits they define. Finally, this research project will synergize with educational opportunities spanning pre-college, undergraduate, and post-graduate levels of science education. The research work of our three groups will directly involve undergraduate researchers and the training of two postdocs.
长期以来,理解颜色图案的形成一直是理解生物学的中心主题。蝴蝶翅膀的颜色图案是探索翅膀图案的历史、基因和机制的主要模型。单个基因(WntA)驱动许多远亲物种的翅膀表面形状变化,从而表明蝴蝶翅膀形成的基本和祖先功能。来自波多黎各大学、乔治华盛顿大学和康奈尔大学的研究小组将调查不同种类蝴蝶翅膀表面色素分布的基因变化。这项研究的目的是确定WntA如何获得在多个时间尺度上控制不同翅膀显示的能力。这项研究将为理解基因调控与形态多样性之间的相互作用奠定基础。技术描述本研究旨在确定基因调控结构如何在不同的时间尺度上与适应性性状一起进化。研究小组将特别关注信号配体WntA在翅膀图案进化中重复作用的调节机制。这项工作将解决WntA空间表达的调节如何在6500万年中修补不同翅膀表型的微观和宏观进化。我们将特别致力于解决以下问题:(1)单个基因中有多少调控元件控制翼型变异,以及单个元件的功能是什么?(2)在不相关的物种中,相同的元素是否也控制着模仿表型的趋同进化?(3)不同翅型差异的物种间,翅型遗传基因的保守性和新颖性在多大程度上不同?回答这些问题将有助于为理解cre进化与它们所定义的性状之间关系的更深层次的系统发育模式树立先例。最后,本研究项目将与大学预科、本科和研究生阶段的科学教育相结合。我们三个小组的研究工作将直接涉及本科生研究人员和两名博士后的培养。
项目成果
期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Bringing immersive science to undergraduate laboratory courses using CRISPR gene knockouts in frogs and butterflies
- DOI:10.1242/jeb.208793
- 发表时间:2020-02
- 期刊:
- 影响因子:2.8
- 作者:Arnaud Martin;Nora S. Wolcott;L. O’Connell
- 通讯作者:Arnaud Martin;Nora S. Wolcott;L. O’Connell
Ultrabithorax Is a Micromanager of Hindwing Identity in Butterflies and Moths
- DOI:10.3389/fevo.2021.643661
- 发表时间:2021-03
- 期刊:
- 影响因子:0
- 作者:A. Tendolkar;A. Pomerantz;Christa Heryanto;P. Shirk;N. Patel;Arnaud Martin
- 通讯作者:A. Tendolkar;A. Pomerantz;Christa Heryanto;P. Shirk;N. Patel;Arnaud Martin
CRISPR/Cas9 as the Key to Unlocking the Secrets of Butterfly Wing Pattern Development and Its Evolution
- DOI:10.1016/bs.aiip.2017.11.001
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:L. Livraghi;Arnaud Martin;M. Gibbs;N. Braak;Saad Arif;C. J. Breuker
- 通讯作者:L. Livraghi;Arnaud Martin;M. Gibbs;N. Braak;Saad Arif;C. J. Breuker
CRISPR in butterflies: An undergraduate lab experience to inactivate wing patterning genes during development
蝴蝶中的 CRISPR:在发育过程中灭活翅膀图案基因的本科生实验室经验
- DOI:10.1002/bmb.21669
- 发表时间:2022
- 期刊:
- 影响因子:1.4
- 作者:Thulluru, Aamani;Saad, Luisa;Nagah Abdou, Yasmin;Martin, Arnaud;Kee, Hooi Lynn
- 通讯作者:Kee, Hooi Lynn
Macroevolutionary shifts of WntA function potentiate butterfly wing-pattern diversity
- DOI:10.1073/pnas.1708149114
- 发表时间:2017-10-03
- 期刊:
- 影响因子:11.1
- 作者:Mazo-Vargas, Anyi;Concha, Carolina;Martin, Arnaud
- 通讯作者:Martin, Arnaud
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Arnaud Martin其他文献
Life and Death of Data in Data Lakes: Preserving Data Usability and Responsible Governance
数据湖中数据的生与死:保持数据可用性和负责任的治理
- DOI:
10.1007/978-3-030-34770-3_24 - 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Marzieh Derakhshannia;C. Gervet;Hicham Hajj;Anne Laurent;Arnaud Martin - 通讯作者:
Arnaud Martin
Genetics of yellow-orange color variation in a pair of sympatric sulfur butterflies.
一对同域硫蝴蝶黄橙色颜色变异的遗传学。
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:8.8
- 作者:
Joseph J. Hanly;C. Francescutti;L. S. Loh;Olaf B W H Corning;Derek J. Long;Marshall A. Nakatani;A. Porter;Arnaud Martin - 通讯作者:
Arnaud Martin
Mapping and CRISPR homology-directed repair of a recessive white eye mutation in emPlodia/em moths
家蚕隐性白眼突变的定位及 CRISPR 同源定向修复
- DOI:
10.1016/j.isci.2022.103885 - 发表时间:
2022-03-18 - 期刊:
- 影响因子:4.100
- 作者:
Christa Heryanto;Joseph J. Hanly;Anyi Mazo-Vargas;Amruta Tendolkar;Arnaud Martin - 通讯作者:
Arnaud Martin
Genetics of continuous colour variation in a pair of sympatric sulphur butterflies
一对同域硫蝴蝶连续颜色变化的遗传学
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Joseph J. Hanly;C. Francescutti;L. S. Loh;Olaf B W H Corning;Derek J. Long;Marshall A. Nakatani;A. Porter;Arnaud Martin - 通讯作者:
Arnaud Martin
SELP: Semi-supervised evidential label propagation algorithm for graph data clustering
SELP:用于图数据聚类的半监督证据标签传播算法
- DOI:
10.1016/j.ijar.2017.09.008 - 发表时间:
2018 - 期刊:
- 影响因子:3.9
- 作者:
周旷;Arnaud Martin;潘泉;刘准钆 - 通讯作者:
刘准钆
Arnaud Martin的其他文献
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{{ truncateString('Arnaud Martin', 18)}}的其他基金
IntBIO: Collaborative Research: Silk Protein Innovation and Novelty (SPIN) : integrating across disciplines to decipher silk fiber evolution
IntBIO:合作研究:丝蛋白创新与新颖(SPIN):跨学科整合,破译丝纤维的进化
- 批准号:
2217156 - 财政年份:2022
- 资助金额:
$ 31.17万 - 项目类别:
Standard Grant
Collaborative Research: RoL: The intersection between cell fate decisions and phenotypic diversification in a rapidly radiating butterfly lineage
合作研究:RoL:快速辐射蝴蝶谱系中细胞命运决定和表型多样化之间的交叉点
- 批准号:
2110534 - 财政年份:2021
- 资助金额:
$ 31.17万 - 项目类别:
Continuing Grant
EDGE CT: Precise genome editing in a lepidopteran insect tailored for stable transformation
EDGE CT:鳞翅目昆虫的精确基因组编辑,专为稳定转化而定制
- 批准号:
1923147 - 财政年份:2019
- 资助金额:
$ 31.17万 - 项目类别:
Standard Grant
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