Collaborative Research: Comparative analyses of structural designs underlying functional performance of the toughest spider silk
合作研究:最坚韧蜘蛛丝功能性能的结构设计比较分析
基本信息
- 批准号:1656645
- 负责人:
- 金额:$ 44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Spider silks are the toughest materials in nature and hold immense promise to inspire a new generation of high-performance synthetic biomaterials. In the rainforests of Madagascar, Darwin's bark spider spins giant orb webs across rivers and lakes using a silk that is far tougher than silk produced by any other known spider. This project aims to understand how Darwin's bark spider produces such 'super' silk and how the silk functions in these giant webs. Through comparison to closely related species, the project will test how newly discovered spinning gland modifications and silk proteins found in Darwin's bark spider interact to produce super tough silk, and if those features are necessary to spin giant webs across rivers. Insight gained from these exceptional spiders will aid in the development of super-silk proteins that can inspire the design of new high-performance materials. Students and postdoctoral researchers will be trained to conduct interdisciplinary research, through direct participation in the project in the US and Madagascar, and through the development of curriculum for a variety of courses, including those offered by The University of Akron's Biomimicry Research and Innovation Center. Public outreach showcasing the natural history of these engaging spiders will provide a platform for linking the study of biodiversity to technological innovation. Such broader impacts will be achieved through an exhibit at the University of Vermont's Natural History Museum and educational activities for students in grades 5-9 at the Tsongas Industrial History Center at Lowell National Historical Park.This project will investigate silk production, structure and biomechanics among Darwin's bark spider (Caerostris darwini) and its close relatives in a comparative framework to determine the key design features underlying super-tough silk and how they evolved with web ecology. The objectives are to: 1) quantify the material properties of dragline fibers and kinematics of Caerostris webs; 2) characterize the structural proteins and spinning gland morphology that form Caerostris dragline silk; and 3) develop a robust Caerostris species phylogeny to infer the evolutionary causes and consequences of extremely tough silk. The work integrates genomic and proteomic analyses of silk proteins with functional characterization of silk threads and finite element modelling of web function and spider ecology. An evolutionary framework provided by phylogenomic analyses will test which traits facilitated the origin of super-tough silk and its implications for the evolution of giant spider webs.
蜘蛛丝是自然界中最坚韧的材料,在激发新一代高性能合成生物材料方面有着巨大的希望。在马达加斯加的热带雨林中,达尔文吠蛛用一种比其他任何已知蜘蛛所产的丝都要坚韧得多的丝,在河流和湖泊之间织出巨大的圆网。这个项目旨在了解达尔文吠蛛是如何产生这种“超级”蛛丝的,以及这些蛛丝在这些巨大的网中是如何起作用的。通过与密切相关的物种进行比较,该项目将测试在达尔文树皮蜘蛛中发现的新发现的纺丝腺修饰和丝蛋白是如何相互作用以产生超级坚韧的丝的,以及这些特征是否对织网跨越河流是必要的。从这些特殊的蜘蛛身上获得的洞察力将有助于开发超级丝蛋白,从而激发新的高性能材料的设计。学生和博士后研究人员将接受培训,通过直接参与美国和马达加斯加的项目,以及通过开发各种课程的课程,包括由阿克伦大学仿生学研究与创新中心提供的课程,进行跨学科研究。向公众展示这些迷人的蜘蛛的自然历史,将为生物多样性研究与技术创新联系起来提供一个平台。这种更广泛的影响将通过佛蒙特大学自然历史博物馆的展览和洛厄尔国家历史公园聪格斯工业历史中心5-9年级学生的教育活动来实现。该项目将研究达尔文吠蛛(Caerostris Darwin)及其近亲的产丝、结构和生物力学,以确定超级坚韧丝的关键设计特征,以及它们如何随着网生态而进化。目标是:1)量化拖丝纤维的材料特性和Caerostris网的运动学;2)研究形成海丝的结构蛋白和纺丝腺形态;3)建立一个强健的毛蚕物种系统发育,以推断出极其坚韧的蚕丝的进化原因和后果。这项工作将丝蛋白的基因组学和蛋白质组学分析与丝线的功能表征以及网功能和蜘蛛生态的有限元建模结合起来。系统基因组学分析提供的进化框架将测试哪些特征促进了超级坚韧丝的起源,以及它对巨型蜘蛛网进化的影响。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
External power amplification drives prey capture in a spider web
- DOI:10.1073/pnas.1821419116
- 发表时间:2019-06-11
- 期刊:
- 影响因子:11.1
- 作者:Han, S. I.;Astley, H. C.;Blackledge, T. A.
- 通讯作者:Blackledge, T. A.
Robust Performance of Spider Viscid Silk on Hairy and Smooth Insect Substrates
蜘蛛粘丝在毛状和光滑昆虫基材上的稳健性能
- DOI:10.1093/icb/icab020
- 发表时间:2021
- 期刊:
- 影响因子:2.6
- 作者:Alicea-Serrano, Angela M;Onyak, Ariel;Dhinojwala, Ali;Blackledge, Todd A
- 通讯作者:Blackledge, Todd A
Supersaturation with water explains the unusual adhesion of aggregate glue in the webs of the moth-specialist spider, Cyrtarachne akirai
- DOI:10.1098/rsos.181296
- 发表时间:2018-11-01
- 期刊:
- 影响因子:3.5
- 作者:Diaz, Candido;Tanikawa, Akio;Blackledge, Todd A.
- 通讯作者:Blackledge, Todd A.
Silk structure rather than tensile mechanics explains web performance in the moth-specialized spider, Cyrtarachne
- DOI:10.1002/jez.2212
- 发表时间:2018-03-01
- 期刊:
- 影响因子:2.8
- 作者:Diaz, Candido;Tanikawa, Akio;Blackledge, Todd A.
- 通讯作者:Blackledge, Todd A.
Correlation between protein secondary structure and mechanical performance for the ultra-tough dragline silk of Darwin's bark spider
- DOI:10.1098/rsif.2021.0320
- 发表时间:2021-06-16
- 期刊:
- 影响因子:3.9
- 作者:Htut, K. Zin;Alicea-Serrano, Angela M.;Dhinojwala, Ali
- 通讯作者:Dhinojwala, Ali
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Todd Blackledge其他文献
Todd Blackledge的其他文献
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{{ truncateString('Todd Blackledge', 18)}}的其他基金
Collaborative Research: Performance and Evolution of Environmentally Responsive Biomaterials in a Unique Biological Adhesive System : Spider Orb Web Capture Threads
合作研究:环境响应型生物材料在独特的生物粘合剂系统中的性能和进化:Spider Orb Web Capture Threads
- 批准号:
1257809 - 财政年份:2013
- 资助金额:
$ 44万 - 项目类别:
Continuing Grant
CAREER: Evolutionary Origins of High Performance Major Ampullate Spider Silk: Development of an Integrated Bioscience Training Program
职业:高性能主要壶腹蜘蛛丝的进化起源:综合生物科学培训计划的开发
- 批准号:
0745379 - 财政年份:2008
- 资助金额:
$ 44万 - 项目类别:
Continuing Grant
Acquisition of a Dynamic Nano-Force Tensile Test System for Ultrathin Fibers with Environmental Control and Integrated Image Analysis
获得具有环境控制和集成图像分析功能的超细纤维动态纳米力拉伸测试系统
- 批准号:
0521261 - 财政年份:2005
- 资助金额:
$ 44万 - 项目类别:
Standard Grant
Collaborative Research: Araneid Phylogeny and Evolution of Spider Silk Phenotypes
合作研究:蜘蛛系统发育和蜘蛛丝表型的进化
- 批准号:
0516038 - 财政年份:2005
- 资助金额:
$ 44万 - 项目类别:
Standard Grant
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- 批准号:10774081
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- 项目类别:面上项目
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