Collaborative Research: RESEARCH-PGR: Comparative genomics of the capitulum: deciphering the molecular basis of a key floral innovation

合作研究:RESEARCH-PGR:头状花序的比较基因组学:破译关键花卉创新的分子基础

基本信息

  • 批准号:
    2214474
  • 负责人:
  • 金额:
    $ 75.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-11-01 至 2026-10-31
  • 项目状态:
    未结题

项目摘要

Sunflowers, daisies, and their relatives belong to a family of plants that make up ca. 10% of flowering plant biodiversity and include numerous species of horticultural, medicinal, and industrial value. This group of flowering plants also contains economically important food crops including artichoke, lettuce, safflower, and sunflower. It is considered one of the most successful plant families due to its large size and global distribution. Key to the success of the family is its inflorescence (a capitulum or flower head) which resembles a single, large flower but is actually an aggregate of many small flowers. This unique floral structure plays an important role in pollinator attraction and is a major determinant of yield in many of the family’s crop species. Despite the importance of the capitulum, little is known about the genes involved in its development. Understanding how inflorescences develop has the potential to improve food security through optimization of floral structures for yield in crops, and by accelerating progress toward new crop development. This project will increase available genomic resources for the family and result in the development of novel tools for gene editing in the family. This work will shed light on the genes involved in the development of the capitulum inflorescence in an economically important family and provide valuable information that will facilitate efforts for optimizing inflorescence architecture in related crops. This project will provide educational opportunities for diverse students and researchers at multiple training levels, through directed efforts to recruit individuals from traditionally underrepresented groups. This project integrates comparative genomics, inflorescence developmental transcriptomics, molecular evolutionary analyses, and functional approaches to decipher the genomic basis of a key floral trait – the capitulum – in the sunflower family (Asteraceae) and related flowering plant lineages. This project will enable the testing of hypotheses related to the role of gene duplication and genome evolution in driving evolutionary novelty, the evolutionary forces involved in the origin of the capitulum, and the repeatability of the evolutionary process across plant lineages. The integrated approach will enable the testing of predictive hypotheses about inflorescence development in Asteraceae and related flowering plant lineages. The primary scientific goals are to: (1) decipher the molecular basis of the Asteraceae capitulum using comparative transcriptomic approaches; (2) determine whether the independent origins of capitula arose via common evolutionary processes and genomic mechanisms; and (3) analyze the functional role of key capitulum genes, targeting established stem cell regulatory genes and candidates identified through comparative/evolutionary genomic analyses. This project will generate high-quality genomes and curated inflorescence transcriptomes for multiple species complemented by comparative genomic and evolutionary analyses. These resources and the resulting data will be disseminated via peer-reviewed publications and public presentations and will be made freely available via deposition in public repositories and databases including the National Center for Biotechnology Information Sequence Read Archive (NCBI-SRA; https://www.ncbi.nlm.nih.gov/sra), Phytozome (https://phytozome-next.jgi.doe.gov/), the Gene Expression Omnibus (GEO; http://ncbi.nlm.nih.gov/geo), FigShare (https://figshare.com/), and Dryad (https://dryad.org/).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
向日葵,雏菊,和他们的亲戚属于一个家庭的植物,使约。10%的开花植物生物多样性,包括许多具有园艺,药用和工业价值的物种。这组开花植物还包含经济上重要的粮食作物,包括朝鲜蓟,莴苣,红花和向日葵。它被认为是最成功的植物家族之一,因为它的大尺寸和全球分布。该家族成功的关键是它的花序(头状花序或花头),类似于一朵大花,但实际上是许多小花的集合体。这种独特的花结构在吸引传粉者方面起着重要作用,并且是该家族许多作物品种产量的主要决定因素。尽管头状花序的重要性,很少有人知道它的发展所涉及的基因。了解花序如何发育有可能通过优化作物产量的花结构和加快新作物开发的进展来提高粮食安全。该项目将为该家族增加可用的基因组资源,并导致开发用于家族基因编辑的新工具。这项工作将揭示在一个经济上重要的家庭中参与头状花序花序发育的基因,并提供有价值的信息,这将有助于优化相关作物的花序结构。该项目将通过定向努力从传统上代表性不足的群体中征聘个人,为不同的学生和研究人员提供多个培训级别的教育机会。该项目整合了比较基因组学,花序发育转录组学,分子进化分析和功能方法,以破译向日葵家族(菊科)和相关开花植物谱系中关键花性状-头状花序的基因组基础。该项目将能够测试与基因复制和基因组进化在驱动进化新奇中的作用有关的假设,参与头状花序起源的进化力量,以及跨植物谱系进化过程的可重复性。综合的方法将使测试的预测假说花序发育在菊科和相关开花植物谱系。主要科学目标是:(1)使用比较转录组学方法破译菊科头状花序的分子基础;(2)确定头状花序的独立起源是否通过共同的进化过程和基因组机制产生;(3)分析关键头状花序基因的功能作用,靶向通过比较/进化基因组分析确定的干细胞调控基因和候选基因。该项目将为多个物种生成高质量的基因组和精选的花序转录组,并辅之以比较基因组和进化分析。这些资源和由此产生的数据将通过同行评审的出版物和公开演讲传播,并将通过存放在公共知识库和数据库(包括国家生物技术信息中心序列读取档案)中免费提供。(NCBI-SRA; https://www.ncbi.nlm.nih.gov/sra),植物带组(https://phytozome-next.jgi.doe.gov/),基因表达综合数据库(GEO; http://ncbi.nlm.nih.gov/geo),FigShare(https://figshare.com/)和Dryad(https://dryad.org/)。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(1)
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Daniel Jones其他文献

Lysophospholipid (S1P) receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
IUPHAR/BPS 药理学指南数据库中的溶血磷脂 (S1P) 受体(版本 2020.5)
  • DOI:
    10.2218/gtopdb/f135/2020.5
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    2.3
  • 作者:
    V. Blaho;J. Chun;Daniel Jones;Deepa Jonnalagadda;Y. Kihara;Valerie Tan
  • 通讯作者:
    Valerie Tan
Evolving Management of Zenker’s Diverticulum in the Endoscopic Era: A North American Experience
内窥镜时代 Zenker 憩室的不断发展的管理:北美经验
  • DOI:
    10.1007/s00268-016-3442-0
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Daniel Jones;A. Aloraini;S. Gowing;J. Cools;M. Leimanis;R. Tabah;L. Ferri
  • 通讯作者:
    L. Ferri
Making a Fascist Family: Spearhead and the Attempt to Build a Nationalist Community Through Magazine Print Culture
打造法西斯家庭:通过杂志印刷文化建立民族主义社区的先锋和尝试
Special and structured matrices in max-plus algebra
最大加代数中的特殊和结构化矩阵
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Daniel Jones
  • 通讯作者:
    Daniel Jones
Management during the First Three Months after Renal Transplantation
肾移植后前三个月的管理
  • DOI:
    10.1002/9781118305294.ch22
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    2.1
  • 作者:
    I. Macphee;J. Popoola;Daniel Jones
  • 通讯作者:
    Daniel Jones

Daniel Jones的其他文献

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{{ truncateString('Daniel Jones', 18)}}的其他基金

Conference: Rocky Mountain Geobiology Symposium 2024
会议:2024 年落基山地球生物学研讨会
  • 批准号:
    2417156
  • 财政年份:
    2024
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Standard Grant
The Gulf Stream control of the North Atlantic carbon sink
湾流对北大西洋碳汇的控制
  • 批准号:
    NE/W009579/1
  • 财政年份:
    2023
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Research Grant
CAREER: Do microbes form caves? Sulfide oxidation and limestone corrosion in sulfuric acid caves
职业:微生物会形成洞穴吗?
  • 批准号:
    2239710
  • 财政年份:
    2023
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Continuing Grant
EAGER: DCL: SaTC: Enabling Interdisciplinary Collaboration: Inoculation vs. education: the role of real time alerts and end-user overconfidence
EAGER:DCL:SaTC:实现跨学科协作:接种与教育:实时警报和最终用户过度自信的作用
  • 批准号:
    2210198
  • 财政年份:
    2022
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Standard Grant
Seabed Mining And Resilience To EXperimental impact
海底采矿和实验影响的恢复能力
  • 批准号:
    NE/T003537/1
  • 财政年份:
    2021
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Research Grant
Autonomous Techniques for anthropogenic Structure Ecological Assessment (AT-SEA)
人为结构生态评估自主技术(AT-SEA)
  • 批准号:
    NE/T010649/1
  • 财政年份:
    2021
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Research Grant
Advaenced state estimats of the ocean and cryosphere: innovative new tools to better understand, predict, and prepare for sea level changes
海洋和冰冻圈的先进状态估计:更好地理解、预测和准备海平面变化的创新工具
  • 批准号:
    MR/T020822/1
  • 财政年份:
    2020
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Fellowship
NSF Postdoctoral Fellowship in Biology FY 2019: Deciphering CLE Peptide Signaling Pathways in Sunflower (Helianthus annuus)
2019 财年 NSF 生物学博士后奖学金:破译向日葵(Helianthus annuus)中的 CLE 肽信号通路
  • 批准号:
    1906389
  • 财政年份:
    2019
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Fellowship Award
EVIST/HST Individual Awards
EVIST/HST 个人奖
  • 批准号:
    8516282
  • 财政年份:
    1985
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Interagency Agreement
American Chemists and the Geneva Protocol
美国化学家和日内瓦议定书
  • 批准号:
    7614312
  • 财政年份:
    1976
  • 资助金额:
    $ 75.2万
  • 项目类别:
    Standard Grant

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