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Copper-mediated reactions of Boron-Element-Compounds: Mechanistic Investigations and Catalytic Applications

硼元素化合物的铜介导反应：机理研究和催化应用

基本信息

批准号：
227688268
负责人：
Privatdozent Dr. Christian Kleeberg
金额：
--
依托单位：
Institut für Anorganische und Analytische Chemie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/227688268?language=en
关键词：
Copper mediated reactions Boron Element

项目摘要

Copper-catalysed transfer reaction of nucleophilic Silicon moieties from element-boron-compounds onto organic substrates are a currently intensively studied group of reactions. These reactions are versatile tools in the synthesis of silicon-containing building-blocks. Recently, several groups reported various copper-catalysed transfer reaction of silicon moieties from boronic acid derivatives onto electrophiles such as aldehydes, alpha, beta-unsaturated carbonyl compounds, allyl chlorids, etc. Despite the similarity of these reactions surprisingly different catalytic-systems have been used. The used catalytic systems may be formally classified into three groups: NHC-copper complexes, phosphan-copper complexes and copper(I) cyanide based systems. Only for the NHC-copper system first mechanistic studies have been reported recently by the applicant.This proposal aims to continue the mechanistic investigation on the NHC-copper systems and moreover extend the mechanistic investigations to the copper(I) cyanide based systems.The gained mechanistic understanding will be used to develop novel NHC-copper complex catalysed transformation of boron-element compounds of group 14. elements. The main focus will be on the extension of the silyl-group transfer reaction to new organic substrates, especially less activated carbonyl compounds (e. g. ketones, esters) and the extension of the scope of the method to other synthetically interesting, previously not used, boron-element compounds. Especially boron-element compounds of carbon are of great synthetic interest. The development of such carbon-element coupling reactions (C-C, C-Si, C-Sn, etc.) should provide a valuable extension to the synthetic chemists tool box.

铜催化的亲核硅基团从元素硼化合物转移到有机底物上的反应是目前研究最多的一类反应。这些反应是合成含硅结构单元的通用工具。最近，几个小组报道了各种铜催化的硅部分从硼酸衍生物转移到亲电子试剂如醛，α，β-不饱和羰基化合物，烯丙基氯等的反应。尽管这些反应的相似性令人惊讶地使用不同的催化体系。所使用的催化体系可以正式地分为三组：NHC-铜络合物、磷-铜络合物和基于氰化铜（I）的体系。本研究的目的是继续对NHC-铜体系的机理研究，并将其扩展到氰化亚铜（I）基体系，所获得的机理理解将用于开发新型的NHC-铜络合物催化的14族硼元素化合物的转化。元素主要的焦点将是硅烷基转移反应的扩展到新的有机底物，特别是活性较低的羰基化合物（如。G.酮、酯）以及将该方法的范围扩展到其它合成上令人感兴趣的、以前未使用的硼元素化合物。尤其是碳的硼元素化合物具有很大的合成兴趣。本文综述了碳-元素偶联反应（C-C、C-Si、C-Sn等）的研究进展。应该为合成化学家的工具箱提供一个有价值的扩展。