REU Site: Membrane Biochemistry and Bioinspired Synthesis

REU 网站：膜生物化学和仿生合成

• 批准号: 1659529
• 负责人: Arne Gericke
• 金额: $ 33.02万
• 依托单位: Worcester Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1659529&HistoricalAwards=false
• 关键词: REU; Site; Membrane; Biochemistry; Bioinspired

Professors Arne Gericke, Shawn Burdette, and colleagues at Worcester Polytechnic Institute (WPI) host the REU Site: Membrane Biochemistry and Bioinspired Synthesis. Funded by the REU Sites Program of the Division of Chemistry, this site provides Students from 2- and 4-yr colleges with the opportunity to participate in a 10-week summer research experience that is designed to expose them to impactful research in membrane biochemistry and bioinspired chemical synthesis. The framework of the program is designed to provide the REU students with the opportunity to be fully engaged in all aspects of the scientific discovery: project conception, execution, troubleshooting, interpretation and dissemination. The REU students are embedded in and interact with an interdisciplinary community of researchers dedicated to tackling challenging problems at the forefront of science. To aid in the process of assembling a diverse group of students each summer, chemistry faculty from three institutions that are separated from the contiguous 48 US States partner with the WPI group: the University of the US Virgin Islands, and the Universities of Alaska at Anchorage and at Fairbanks. All of these schools serve large populations of underrepresented students.The REU students pursue projects in the areas of membrane biochemistry and bioinspired chemical synthesis. The synthetic projects involve mechanistic studies of anion binding for enantioselective carbon-carbon bond formations and porous metal organic frameworks as host materials for molecular storage and release. The membrane biochemistry projects are concerned with metal ion permeation through transport proteins, membrane composition and stress survival in C. elegans, and the effect of ether lipids on membrane morphology among other projects.

伍斯特理工学院(WPI)的Arne Gericke教授、Shawn Burderte教授和他的同事主持了REU网站：膜生物化学和生物灵感合成。该网站由化学系REU Sites计划资助，为二年制和四年制大学的学生提供参加为期10周的暑期研究体验的机会，旨在让他们接触到膜生物化学和生物启发的化学合成方面的有影响力的研究。该计划的框架旨在为REU学生提供充分参与科学发现的所有方面的机会：项目构思、执行、故障排除、解释和传播。REU的学生融入了一个跨学科的研究社区，并与之互动，这些研究人员致力于解决科学前沿的挑战性问题。为了帮助每年夏天聚集不同群体的学生，来自与美国毗邻的48个州分开的三个机构的化学系与WPI小组合作：美属维尔京群岛大学，以及安克雷奇和费尔班克斯的阿拉斯加大学。所有这些学校都服务于大量代表不足的学生。REU的学生在膜生物化学和生物启发的化学合成领域进行项目。这些合成项目包括用于形成对映选择性碳-碳键的阴离子结合的机理研究，以及作为分子储存和释放的主体材料的多孔金属有机骨架。膜生物化学项目涉及金属离子通过转运蛋白的渗透，线虫的膜组成和逆境生存，以及乙醚类脂对膜形态的影响等项目。

项目成果

A Strategy for Trapping Molecular Guests in MOF-5 Utilizing Surface-Capping Groups

• DOI: 10.1021/acs.cgd.9b00818
• 发表时间: 2019-10
• 期刊: Crystal Growth & Design
• 影响因子: 3.8
• 作者: Rick A Homan;Dalton S. Hendricks;Thomas M. Rayder;U. S. Thein;Katherine J Fossum;Adriana P. Claudio Vázquez;Jingjing Yan;Ronald L. Grimm;Shawn C Burdette;John C. MacDonald

On-demand guest release from MOF-5 sealed with nitrophenylacetic acid photocapping groups

由硝基苯乙酸光封端基团密封的 MOF-5 按需释放客体

• DOI: 10.1039/c9pp00392d
• 发表时间: 2019
• 期刊: Photochemical & Photobiological Sciences
• 影响因子: 3.1
• 作者: Yan, Jingjing;Homan, Rick A.;Boucher, Corrianna;Basa, Prem N.;Fossum, Katherine J.;Grimm, Ronald L.;MacDonald, John C.;Burdette, Shawn C.
• 通讯作者: Burdette, Shawn C.