Developing Metallacrown Scaffolds for Luminescence, Magnetism and Supramolecular Chemistry

密歇根大学安娜堡分校化学系的Vincent Pecoraro教授在化学结构、动力学和机制B项目资助的这个项目中，正在开发新型的金属巨环配合物，称为金属冠。这类配合物在磁性和成像方面具有重要的技术特性。它们在近红外发光传感器、无机发光二极管和条形码标签以及量子计算方面具有潜在的应用前景。显像剂是可专利的，并且正在讨论许可细胞固定和坏死分析。该项目位于有机、无机和生物化学的界面。它非常适合各级科学家的教育和国际边界。它也是居里夫人国际研究人员交流计划的基础，该计划将欧洲各地的年轻科学家带到美国接受培训，并将文森特·佩科拉罗教授小组的学生带到欧洲。涉及K-12学生和在科学领域代表性不足的学生的外展活动也是资助项目的一部分。金属王冠显示出丰富的光物理性质，包括在近红外光谱区域发射的分子镧系化合物的最高量子产率和亮度。此外，包裹在抗磁性金属冕中的双核镧系元素显示出能量缺口，适合用于开发量子计算机的量子比特。提出的工作利用这些性质来产生用于成像应用的发光树突和Janus树突。简单的金属冠motif也将被用作开发可用于传感应用的发光金属有机框架的节点。这些研究通过导致具有磁性或发光性质的新结构类型，拓宽了树状大分子和金属有机框架的合成可能性。

In this project funded by the Chemical Structure, Dynamic & Mechanism B Program of the Chemistry Division, Professor Vincent Pecoraro of the Department of Chemistry at the University of Michigan, Ann Arbor is developing new classes of metallamacrocylic complexes called metallacrowns. These classes of complexes exhibit technologically important properties in magnetism and imaging. They have potential applications in near-infrared luminescent sensors, inorganic light emitting diodes and bar code labels, and quantum computing. The imaging agents are patentable and discussions are underway for licensing for cell fixation and necrosis assays. The project lies at the interface of organic, inorganic, and biological chemistry. It is well suited to the education of scientists at all levels and across international boundaries. It also serves as the basis for a Marie Curie International Research Staff Exchange Scheme program that brings junior scientists across Europe to the US for training and students from Professor Vincent Pecoraro's group to Europe. Outreach activities involving K-12 students and for students underrepresented in science are also part of the funded project. Metallacrowns display a rich array of photophysical properties, including the highest reported quantum yields and brightness for molecular Lanthanide complexes emitting in the near infrared spectral region. In addition, binuclear lanthanides encapsulated within diamagnetic metallacrowns show energy gaps that are appropriate for exploitation as qubits for the development of quantum computers. The proposed work exploits these properties to generate luminescent dendrimers and Janus dendrimers for imaging applications. The simple metallacrown motif will also be used as nodes to develop luminescent metal organic frameworks that may be used for sensing applications. These studies broaden the range of synthetic possibilities for both dendrimers and metal organic frameworks by leading to new structure types with either magnetic or luminescent properties.