Overcoming Adsorption Limitations for Surface Enhanced Spectroscopy Measurements

克服表面增强光谱测量的吸附限制

• 批准号: 1707859
• 负责人: Mark Arnold
• 金额: $ 33万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1707859&HistoricalAwards=false
• 关键词: Overcoming; Adsorption; Limitations; Surface; Enhanced

New biological, chemical, and radiological agents threaten the environment and human safety every day. While significant advances in small molecule detection have been made, challenges still exist in providing flexible detection methodologies for accurate chemical identification and sensitive and selective detection of some molecules. With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Haes at the University of Iowa focuses on developing surface sensitive techniques such as surface enhanced Raman scattering (SERS) as a tool molecular detection. SERS is a light-based technique that is used to identify and quantify molecules that adsorb onto metal surfaces. Most molecules do not stick to metal surfaces, limiting the utility of SERS and similar methods. Professor Haes and her group use both experimental and modeling methods to develop the SERS technique so that it can be used to provide accurate chemical identification with high selectivity and sensitivity. Through this research, Professor Haes provides opportunities to graduate and undergraduate students to work on practical problems. The Haes research group performs outreach activities with K-12 students that are focused on the "Size of Things". This project helps students learn about the implications of size on the properties of nanoscale and macroscale objects through hands-on activities. Underrepresented minority students are recruited through the University of Iowa's Center of Exemplary Mentoring. In addition, all personnel participate in educational development and outreach activities geared towards introducing science to Iowa's students in grades K-12. Specifically, Dr. Haes develops a "Size of Things" exhibit for display with a learning game for the size of nanoscale and macroscale objects. They build off of educational activities developed by Public Television (DragonTV on Nano)and provide interactive activities related to (1) What is a nanometer? How big is one billion meters? How small is one-billionth of a meter?; (2) Why is "nanogold" red and "nanosilver" yellow?; and (3) My nanosilver socks do not smell but should I be worried that the nanosilver will get into my body? This project seeks answers regarding how and why some molecules are difficult to detect using SERS. Despite many successful examples of direct small molecule detection using SERS, at least three issues remain including: (1) unpredictable properties of nanomaterials that arise from aggregation, (2) inefficient binding of some classes of molecules to surfaces, and (3) low signals associated with targeted molecules. The two research questions are answered by varying nanoparticle morphology and solution conditions. Research tasks focus on quantifying molecular binding metrics and SERS enhancements and evaluating how solution conditions impact binding metrics, nanoparticle stability, and SERS activity. Key experimental design features are identified so adsorbate-surface interactions are rationally and reproducibly promoted thus facilitating direct detection of molecules using surface-enhanced spectroscopies. Students are trained in the areas of nanoscience, spectroscopy, and measurement science. Through the supported research, the Haes research group is developing design rules that overcome current measurement challenges thus expanding the utility of SERS in a variety of applications.

新的生物、化学和放射性制剂每天都在威胁环境和人类安全。虽然在小分子检测方面已经取得了显著的进展，但是在提供用于精确化学鉴定以及敏感和选择性检测一些分子的灵活检测方法方面仍然存在挑战。在化学系化学测量和成像项目的支持下，爱荷华州大学的Haes教授专注于开发表面敏感技术，如表面增强拉曼散射（Sers）作为分子检测工具。Sers是一种基于光的技术，用于识别和量化吸附在金属表面上的分子。大多数分子不能粘附在金属表面，限制了Sers和类似方法的实用性。Haes教授和她的团队使用实验和建模方法来开发Sers技术，以便它可以用于提供具有高选择性和灵敏度的准确化学鉴定。 通过这项研究，Haes教授为研究生和本科生提供了解决实际问题的机会。 Haes研究小组与K-12学生一起开展外展活动，重点是“事物的大小”。 本专题透过实践活动，帮助学生了解大小对奈米尺度及宏观尺度物体性质的影响。 代表性不足的少数民族学生是通过爱荷华州大学的示范指导中心招募的。 此外，所有人员都参加教育发展和推广活动，旨在向爱荷华州K-12年级的学生介绍科学。具体来说，Haes博士开发了一个“事物的大小”展览，用于展示纳米尺度和宏观尺度物体的大小的学习游戏。他们建立了由公共电视台开发的教育活动（DragonTV on Nano），并提供与（1）什么是纳米？10亿米有多大？十亿分之一米有多小？(2)为什么“纳米金”是红色而“纳米银”是黄色？和（3）我的纳米银袜子没有气味，但我应该担心纳米银会进入我的身体吗？该项目寻求关于如何以及为什么一些分子难以使用Sers检测的答案。尽管使用Sers的直接小分子检测有许多成功的例子，但仍然存在至少三个问题，包括：（1）由聚集引起的纳米材料的不可预测的性质，（2）某些类别的分子与表面的低效结合，以及（3）与靶向分子相关的低信号。这两个研究问题的答案是不同的纳米粒子形态和解决方案的条件。研究任务侧重于量化分子结合指标和Sers增强，并评估溶液条件如何影响结合指标，纳米颗粒稳定性和Sers活性。确定了关键的实验设计特征，从而合理地和可重复地促进吸附物-表面相互作用，从而便于使用表面增强光谱直接检测分子。学生接受纳米科学，光谱学和测量科学领域的培训。通过支持的研究，Haes研究小组正在开发克服当前测量挑战的设计规则，从而扩展Sers在各种应用中的实用性。

项目成果

Quantitative Surface-Enhanced Spectroscopy.

定量表面增强光谱。

• DOI: 10.1146/annurev-physchem-082720-033751
• 发表时间: 2022
• 期刊: Annual review of physical chemistry
• 影响因子: 14.7
• 作者: Norton,RyanD;Phan,HoaT;Gibbons,StephanieN;Haes,AmandaJ
• 通讯作者: Haes,AmandaJ

Elucidation of pH impacts on monosubstituted benzene derivatives using normal Raman and surface-enhanced Raman scattering.

• DOI: 10.1063/5.0029445
• 发表时间: 2020-11
• 期刊: The Journal of chemical physics
• 作者: Wenjing Xi;A. Haes

Vibrational Frequency Shifts for Monitoring Noncovalent Interactions between Molecular Imprinted Polymers and Analgesics

• DOI: 10.1021/acs.jpcc.8b07771
• 发表时间: 2018-09
• 期刊: The Journal of Physical Chemistry C
• 作者: Wenjing Xi;Anna A. Volkert;Michael C. Boller;A. Haes

How to accurately predict solution-phase gold nanostar stability.

• DOI: 10.1007/s00216-018-1115-6
• 发表时间: 2018-09
• 期刊: Analytical and bioanalytical chemistry
• 影响因子: 4.3
• 作者: Xi W;Phan HT;Haes AJ
• 通讯作者: Haes AJ

Impacts of pH and Intermolecular Interactions on Surface-Enhanced Raman Scattering Chemical Enhancements

• DOI: 10.1021/acs.jpcc.8b04019
• 发表时间: 2018-07-05
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY C
• 影响因子: 3.7
• 作者: Phan, Hoa T.;Haes, Amanda J.
• 通讯作者: Haes, Amanda J.