Acquisition of a GC-TOF Mass Spectrometer

购买 GC-TOF 质谱仪

• 批准号: 0946779
• 负责人: Mark Arnold
• 金额: $ 22.54万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-15 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0946779&HistoricalAwards=false
• 关键词: Acquisition; GC; TOF; Mass; Spectrometer

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professors David F. Wiemer, James B. Gloer and Lynn Teesch from the University of Iowa will acquire a high resolution gas-chromatograph time-of-flight mass spectrometer (GC-TOF-MS) capable of carrying out experiments with electron ionization (EI) and chemical ionization (CI) sources. The instrument will be used to support research activities such as: 1) isolation and structure determination of bioactive natural products from fungi; 2) studies of manganese-mediated coupling reactions for the synthesis of natural products; 3) studies of Pd(II)- and Ni(II)-catalyzed synthesis of aminoglycosides and other biologically active carbohydrates; 4) studies of dearomatization approaches to the synthesis of carboxylic and heterocyclic natural products; and 5) characterization of synthetic terpenoid phosphonates and schweinfurthin analogues.GC-TOF-mass spectrometry is an important technique for obtaining accurate molecular weights on large molecules, with high sensitivity. Use of a GC-TOF mass spectrometer with easily exchanged ionization sources is a standard technique for the study of chemical reactions. The instrument is capable of using volatile or semi-volatile samples that can be introduced through the gas chromatograph. An autosampler will accommodate multiple sample experiments. Solid samples will be introduced either on the heated direct insertion probe or on the direct chemical ionization probe. This research will have a significant impact in a number of areas, especially chemistry, natural products and biochemistry. This instrument will be an integral part of teaching as well as research.

爱荷华大学的David F.Wiemer、James B.Gloer和Lynn Teesch教授获得了化学研究仪器和设备：系多用户仪器计划(CRIF：MU)颁发的这一奖项，他们将获得一台能够使用电子电离(EI)和化学电离(CI)源进行实验的高分辨率气相色谱飞行时间质谱仪(GC-TOF-MS)。该仪器将用于支持下列研究活动：1)真菌中生物活性天然产物的分离和结构测定；2)天然产物合成中锰介导的偶联反应的研究；3)Pd(II)和Ni(II)催化合成氨基糖苷和其他生物活性碳水化合物的研究；4)合成羧酸和杂环天然产物的脱芳构化方法研究；以及5)合成萜类磷酸盐和五氢呋喃类似物的表征。GC-TOF-MS是获得大分子准确分子量的重要技术，具有高灵敏度。使用易于更换电离源的GC-TOF质谱仪是研究化学反应的标准技术。该仪器能够使用挥发性或半挥发性样品，可以通过气相色谱仪引入。一台自动取样器可以容纳多个样品实验。固体样品将通过加热的直接插入探头或直接化学电离探头引入。这项研究将在多个领域产生重大影响，特别是化学、天然产物和生物化学。该仪器将成为教学和研究不可或缺的一部分。