Collaborative Research: Conformal and robust integrated infrared spectroscopic sensors

合作研究:共形且坚固的集成红外光谱传感器

基本信息

  • 批准号:
    1708768
  • 负责人:
  • 金额:
    $ 20万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-01 至 2018-10-31
  • 项目状态:
    已结题

项目摘要

The program aims to pioneer a flexible optical sensor which can be conformally attached to human skin for continuous physiological monitoring. Unlike conventional optical sensors which are often bulky, costly, and involve mechanical moving parts which compromise their robustness, the proposed effort will leverage advanced integrated photonic technologies to combine miniaturized optical components on a flexible polymer membrane. The proposed sensor is ideally suited for continuous glucose monitoring. Instead of relying on fingertip pricking with lancets to draw blood for intermittent analysis, the proposed sensor will assume a minimally invasive, tattoo-like form factor for continuous monitoring of glucose concentration in body fluids.Integrated photonic devices are uniquely poised for in-vivo sensing, diagnostics, therapeutics, and stimulation functions, given their small form factor, low power consumption, robustness, large multiplexing capacity, as well as strong light-molecule/tissue interactions enabled by tight optical confinement in these devices. Nevertheless, conventional photonic integration is predominantly based on rigid semiconductor substrates, and their mechanical stiffness makes the resulting devices inherently incompatible with soft biological tissues. Further, while optical spectroscopy based on bench top instruments has become the gold standard in analytical chemistry, integrated spectroscopic sensors remain largely unexplored. This program aims to resolve the challenges by combining flexible photonic integration and on-chip infrared spectroscopic sensing technologies to pioneer a wearable photonic sensing system on conformal plastic substrates. Specifically, a minimally invasive epidermal sensor for continuous glucose monitoring will be demonstrated as a proof-of-concept model platform. The two-fold intellectual merits of the program lie in the unconventional multi-material photonic integration approach on conformal substrates as well as the innovative spectroscopic sensor design. Photonic integration on conformal substrates poses a diverse set of often mutually conflicting requirements on the mechanical and optical properties of constituent materials. In this program, a transformative multi-material, multi-functional integration approach on flexible substrates will be pursued where each material is seamlessly integrated into the process flow and strategically shaped and positioned so as to make use of its advantageous properties while circumventing its limitations. On the spectroscopic sensing front, miniaturization and integration of spectrometers present a major technical barrier towards spectroscopic sensor integration onto chip-scale platforms. Rather than downscaling traditional spectrometers, the program will develop a novel sensor design with significantly improved system simplicity, ruggedness, reproducibility and specificity, enabling wearable sensing applications. The scientific research will be tightly integrated with curriculum development, undergraduate student training, and development of hands-on modules for optics education. In addition to augmenting classroom education at both institutes, the program will promote the free sharing and distribution of knowledge by developing online courses through the MIT OpenCourseWare and edX initiatives.
该项目旨在开创一种柔性光学传感器,这种传感器可以共形连接到人体皮肤上,用于持续的生理监测。传统的光学传感器通常笨重、成本高昂,而且涉及机械移动部件,影响了它们的坚固性,与之不同的是,拟议的努力将利用先进的集成光子技术将微型化的光学元件组合在柔性聚合物薄膜上。该传感器非常适合于血糖的连续监测。与依靠指尖刺血进行间歇性分析不同,该传感器将采用微创、纹身状的外形系数来连续监测体液中的葡萄糖浓度。集成的光子器件具有体积小、功耗低、坚固耐用、多路复用能力大以及通过这些器件中严格的光学限制实现强烈的光-分子/组织相互作用,因此独特地适合于体内传感、诊断、治疗和刺激功能。然而,传统的光子集成主要基于刚性半导体衬底,其机械刚性使得所产生的器件与软生物组织固有地不兼容。此外,尽管基于台式仪器的光学光谱学已经成为分析化学的黄金标准,但集成的光谱传感器在很大程度上仍未得到探索。该计划旨在通过结合灵活的光子集成和片上红外光谱传感技术来解决这些挑战,开创在保形塑料基板上的可穿戴光子传感系统。具体地说,用于持续血糖监测的微创表皮传感器将作为概念验证模型平台进行演示。该计划的双重智能优点在于在共形衬底上采用非传统的多材料光子集成方法,以及创新的光谱传感器设计。共形衬底上的光子集成对组成材料的机械和光学特性提出了一系列相互冲突的不同要求。在该计划中,将在柔性基板上追求变革性的多材料、多功能集成方法,其中每种材料都无缝地集成到工艺流程中,并对其进行战略性塑造和定位,以利用其优势特性,同时绕过其限制。在光谱传感方面,光谱仪的小型化和集成化是将光谱传感器集成到芯片级平台上的主要技术障碍。该计划将开发一种新的传感器设计,显著提高系统简单性、坚固性、重复性和特异性,使可穿戴式传感应用成为可能,而不是缩小传统光谱仪的规模。科学研究将与课程开发、本科生培养以及光学教育实践模块的开发紧密结合。除了加强两所学院的课堂教育外,该计划还将通过麻省理工学院开放式课程软件和edX倡议开发在线课程,促进知识的免费共享和传播。

项目成果

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Mo Li其他文献

Pathogenic memory Th2細胞とアレルギ-性炎症制御
致病性记忆 Th2 细胞与过敏性炎症控制
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mo Li;Shaoying Liu;中山俊憲
  • 通讯作者:
    中山俊憲
KAIMRC’S Second Therapeutics Discovery Conference
KAIMRC 第二届治疗药物发现会议
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Z. Alehaideb;N. Mehyar;Mai Al Ajaji;M. Alassiri;Manal A. Alaamery;B. Debasi;B. Alghanem;Jahad Alghamdi;Bahauddeen M. Alrfaei;B. A. Somaie;A. Bakillah;Tlili Barhoumi;Yosra Boudjelal;Ibrahim Bushnak;M. Alfadhel;S. Gul;I. Islam;Mo Li;T. S. Lim;S. Massadeh;Lamis Mouyes;A. Nefzi;Atef Nehdi;W. Yue;A. Alaskar;M. Boudjelal
  • 通讯作者:
    M. Boudjelal
An Improved Video Target Tracking Algorithm Based on Particle Filter and Mean-Shift
一种基于粒子滤波和Mean-Shift的改进视频目标跟踪算法
  • DOI:
    10.1007/978-3-642-34531-9_43
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zheyi Fan;Mo Li;Zhiwen Liu
  • 通讯作者:
    Zhiwen Liu
Spectrally coded multiplexing for fibre grating sensor systems
光纤光栅传感器系统的光谱编码复用
  • DOI:
    10.1117/12.837633
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    P. Childs;A. Wong;B. Yan;Mo Li;G. Peng
  • 通讯作者:
    G. Peng
BiLock: User Authentication via Dental Occlusion Biometrics
BiLock:通过牙齿咬合生物识别技术进行用户身份验证

Mo Li的其他文献

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{{ truncateString('Mo Li', 18)}}的其他基金

U.S.-Japan University Partnership for Workforce Advancement and Research & Development in Semiconductors (UPWARDS) for the Future
美日大学劳动力发展和研究合作伙伴关系
  • 批准号:
    2329784
  • 财政年份:
    2023
  • 资助金额:
    $ 20万
  • 项目类别:
    Continuing Grant
C: Photonic Engine to Accelerate Atomic Quantum Engineering (PEAQUE)
C:加速原子量子工程的光子引擎(PEAQUE)
  • 批准号:
    2134345
  • 财政年份:
    2021
  • 资助金额:
    $ 20万
  • 项目类别:
    Cooperative Agreement
NSF Convergence Accelerator-Track C: Chip-Scale Integrated Multibeam Steering System for Cold-Atom Quantum Computing
NSF 融合加速器-Track C:用于冷原子量子计算的芯片级集成多波束转向系统
  • 批准号:
    2040527
  • 财政年份:
    2020
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
Collaborative Research: Quantum acoustics for optomechanical transduction and entanglement of solid-state spin qubits
合作研究:用于光机械传导和固态自旋量子位纠缠的量子声学
  • 批准号:
    2006103
  • 财政年份:
    2020
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
CAREER: Integration of 2D materials for broadband silicon photonics
职业:宽带硅光子学二维材料的集成
  • 批准号:
    1915018
  • 财政年份:
    2018
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
Collaborative Research: Conformal and robust integrated infrared spectroscopic sensors
合作研究:共形且坚固的集成红外光谱传感器
  • 批准号:
    1854974
  • 财政年份:
    2018
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
Workshop: Bilateral Photonics Workshop of the National Science Foundation (NSF) and Ministry of Science and Technology (MOST), Taiwan, May 29-June 1, 2015
研讨会:美国国家科学基金会 (NSF) 和科学技术部 (MOST) 双边光子学研讨会,台湾,2015 年 5 月 29 日至 6 月 1 日
  • 批准号:
    1536097
  • 财政年份:
    2015
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
CAREER: Integration of 2D materials for broadband silicon photonics
职业:宽带硅光子学二维材料的集成
  • 批准号:
    1351002
  • 财政年份:
    2014
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
Workshop: Support to Speakers to Attend IEEE Photonics Society Topical Conference on Non-reciprocal Photonic Devices, Hawaii, July 8-10, 2013
研讨会:支持演讲者参加 IEEE 光子学会非互易光子器件专题会议,夏威夷,2013 年 7 月 8 日至 10 日
  • 批准号:
    1339002
  • 财政年份:
    2013
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant
Integrated surface acousto-optical devices on piezoelectric aluminum nitride thin films
压电氮化铝薄膜上的集成表面声光器件
  • 批准号:
    1307601
  • 财政年份:
    2013
  • 资助金额:
    $ 20万
  • 项目类别:
    Standard Grant

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合作研究:用于超声波放大和改进诊断的共形梯度折射率透镜
  • 批准号:
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