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Iron(III) Coordination Complexes as MRI Contrast Agents

铁 (III) 配位络合物作为 MRI 造影剂

基本信息

批准号：
1710224
负责人：
Janet Morrow
金额：
$ 48.94万
依托单位：
SUNY at Buffalo
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1710224&HistoricalAwards=false
关键词：
Iron III Coordination Complexes MRI

项目摘要

In this project funded by the Chemical Structure, Dynamic & Mechanism B and the Chemical Measurement & Imaging Programs of the Chemistry Division, Professor Janet R. Morrow of the Department of Chemistry at the University at Buffalo, State University of New York is developing new classes of iron (Fe) complexes as magnetic resonance imaging (MRI) contrast agents. The goal of this research is to obtain new iron-based agents that produce effective MRI contrast at the field strengths found in the newest MRI scanners. Iron is a biologically relevant metal ion that may be an alternative to the currently used gadolinium, which has tolerance issues in imaging. The project lies at the interface of organic and inorganic chemistry, as well as physiology and imaging physics and is therefore well suited to the education of scientists at all levels. Professor Morrow has a strong record of educating a diverse group of graduate and undergraduate students. Outreach activities involving K-12 students and their science teacher are also be part of the funded project. Macrocyclic Fe(III) complexes are being developed as MRI contrast agents with the goal of obtaining agents that produce effective T1 contrast at the clinically relevant magnetic field of 3 Tesla (T). The complexes contain highly stabilized Fe(III) centers that do not produce reactive oxygen species. Complexes that contain one bound water or no water ligands are to be studied to assess the effect of outer versus innersphere water on T1 relaxivity. A second emphasis is to develop Fe(III) contrast agents that change paramagnetic properties with temperature and pH. These spin state changes interconvert Fe(III) paramagnetic CEST (Chemical Exchange Saturation Transfer) agents and T1 contrast agents. EPR (Electron paramagnetic resonance) and Mossbauer spectroscopy will be used for characterization of the complexes. To study the magnetic field strength dependence of relaxivity, the complexes will be studied on MRI scanners at 1.5 T, 3.0 T and 4.7 T. A nuclear magnetic resonance dispersion spectrum will be obtained for selected Fe(III) complexes. The most effective Fe(III) contrast agents will be studied and compared to Gd(III) contrast agents in biological samples.

本研究由化学系化学结构、动力学机制B和化学测量成像项目资助，纽约州立大学布法罗分校化学系的Morrow正在开发新型铁（Fe）络合物作为磁共振成像（MRI）造影剂。本研究的目标是获得新的铁基试剂，在最新的MRI扫描仪中发现的场强下产生有效的MRI对比度。铁是一种生物学相关的金属离子，可以替代目前使用的钆，钆在成像中存在耐受性问题。该项目位于有机和无机化学，以及生理学和成像物理学的接口，因此非常适合各级科学家的教育。莫罗教授在教育研究生和本科生的多样化群体方面有着良好的记录。涉及K-12学生和他们的科学老师的外联活动也是资助项目的一部分。大环Fe（III）络合物正被开发为MRI造影剂，目标是获得在3特斯拉（T）的临床相关磁场下产生有效T1造影剂的试剂。配合物含有高度稳定的Fe（III）中心，不产生活性氧。研究含有一个束缚水或不含水配体的络合物，以评估外层水与内层水对T1弛豫率的影响。第二个重点是开发随温度和pH值改变顺磁性的Fe（III）造影剂。这些自旋状态变化使Fe（III）顺磁性CEST（化学交换饱和转移）剂和T1造影剂相互转换。EPR（电子顺磁共振）和穆斯堡尔谱将用于表征的复合物。为了研究弛豫率的磁场强度依赖性，将在1.5 T、3.0 T和4.7 T的MRI扫描仪上研究复合物。将获得选定的Fe（III）配合物的核磁共振色散谱。将研究最有效的Fe（III）造影剂，并与生物样本中的Gd（III）造影剂进行比较。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Saccharomyces cerevisiae and Candida albicans Yeast Cells Labeled with Fe(III) Complexes as MRI Probes

用 Fe(III) 复合物标记的酿酒酵母和白色念珠菌酵母细胞作为 MRI 探针

DOI：
10.3390/magnetochemistry6030041
发表时间：
2020
期刊：
Magnetochemistry
影响因子：
2.7
作者：
Patel, Akanksha;Asik, Didar;Snyder, Eric M.;Spernyak, Joseph A.;Cullen, Paul J.;Morrow, Janet R.
通讯作者：
Morrow, Janet R.

Exploring Inner-Sphere Water Interactions of Fe(II) and Co(II) Complexes of 12-Membered Macrocycles To Develop CEST MRI Probes