EAPSI: Synthesis of Thiolated Carboranes for Self-Assembled Monolayers on a Dy-doped CdO Surface

EAPSI：在掺镝氧化镉表面自组装单层硫醇化碳硼烷的合成

• 批准号: 1713815
• 负责人: Hniang Khamh
• 金额: $ 0.54万
• 依托单位: Khamh Hniang
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1713815&HistoricalAwards=false
• 关键词: EAPSI; Synthesis; Thiolated; Carboranes; Self

This project aims to synthesize thiolated carboranes, organic molecules that are stable in water and extreme heat. These organic molecules will be attached to a plasmonic active material - cadmium oxide doped with dysprosium (CdO:Dy) - to protect it from being soluble in water and acidic solutions. CdO:Dy was recently reported as the first semiconductor that can host surface plasmons in the mid-infrared region as well as being an ideal material for mid-infrared biosensor chips. Investigation regarding whether or not the infrared vibration of these organic molecules can be detected when attached on CdO:Dy using Surface Plasmon Resonance (SPR) spectrometry will be performed in addition to exploring the possibility of using CdO:Dy as a biosensor chip. This project will be conducted at Zhejiang University in China with Professor Simon Duttwyler, an expert in carboranes synthesis. This work will lead to development of a sensitive mid-IR biosensor that can be used in drug discovery and also in small molecule detection for scientific research.A recently reported plasmonic active material, dysprosium doped cadmium oxide (CdO:Dy) possesses extreme peak of mobility and tunable carrier concentration giving rise to Surface Plasmon Resonance across the mid-IR range. Though CdO:Dy is an ideal mid-IR material for a biosensor due to its spectrally narrow and sharp plasmonic band, its solubility in water and instability in acidic solution pose many challenges experimentally. To overcome these obstacles, an objective of this EAPSI project aims to synthesize extremely hydrophobic and thermally stable molecules, thiolated carboranes, that will not only protect CdO substrate from (acidic) solutions, but also permit subsequent detection of these molecules through Surface Plasmon Resonance (SPR) spectroscopy; this will also facilitate the simultaneous investigation of potentially using CdO:Dy as a biosensor. Furthermore, thiolated carboranes will be deposited on CdO:Dy substrate using self-assembled monolayer, furthering the fundamental understanding of surface chemistry between Dy-doped CdO surface and organic molecules.This award under the East Asia and Pacific Summer Institutes program supports summer research by a U.S. graduate student and is jointly funded by NSF and the Chinese Ministry of Science and Technology.

该项目旨在合成硫醇化碳硼烷，这是一种在水中和极热下稳定的有机分子。这些有机分子将附着在等离子体活性材料上-掺杂镝的氧化镉（CdO：Dy）-以保护其不溶于水和酸性溶液。CdO：Dy是第一种能够在中红外区域内形成表面等离子体的半导体材料，也是中红外生物传感器芯片的理想材料。除了探索使用CdO：Dy作为生物传感器芯片的可能性之外，还将进行关于这些有机分子的红外振动在使用表面等离子体共振（SPR）光谱法附着在CdO：Dy上时是否可以被检测到的调查。该项目将在中国浙江大学进行，由碳硼烷合成专家Simon Duttwyler教授主持。该工作将有助于开发一种灵敏的中红外生物传感器，可用于药物发现和小分子检测。最近报道的一种等离子体活性材料，镝掺杂的氧化镉（CdO：Dy）具有极高的迁移率峰值和可调的载流子浓度，从而在中红外范围内产生表面等离子体共振。虽然CdO：Dy是一种理想的中红外生物传感器材料，由于其光谱窄和尖锐的等离子体带，其在水中的溶解性和在酸性溶液中的不稳定性提出了许多挑战实验。为了克服这些障碍，EAPSI项目的一个目标是合成极其疏水和热稳定的分子，硫醇化碳硼烷，这不仅可以保护CdO底物免受（酸性）溶液的影响，而且还可以通过表面等离子体共振（SPR）光谱对这些分子进行后续检测;这也将有助于同时研究可能使用CdO：Dy作为生物传感器。此外，巯基化碳硼烷将通过自组装单分子层沉积在CdO：Dy基底上，进一步加深对Dy掺杂的CdO表面与有机分子之间的表面化学的基本理解。该奖项属于东亚和太平洋夏季研究所计划，支持美国研究生的夏季研究，由NSF和中国科技部共同资助。