SBIR Phase I: Robust Nanofiltration to Enable Challenging Chemical and Pharmaceutical Separations

SBIR 第一阶段：强大的纳滤技术可实现具有挑战性的化学和药物分离

• 批准号: 1722157
• 负责人: Shreya Dave
• 金额: $ 22.5万
• 依托单位: Via Separations, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1722157&HistoricalAwards=false
• 关键词: SBIR; Phase; Robust; Nanofiltration; Enable

The broad impact of the proposed SBIR project is in the development of Graphene oxide based filtration membranes in industrial applications, such as pharmaceutical and chemical production. Current polymer membranes are not meeting specific industrial needs and are unlikely to do so with incremental innovation. On the other hand, converting from distillation and evaporation to membrane-based separation has the potential to reduce energy consumption in the US by 10%. The proposed graphene oxide based material is a robust nanomaterial that is capable of separating streams at the molecular level while withstanding the challenging environments of chemical separations. Successful implementation will increase process intensification and energy efficiency for pharmaceutical and chemical producers, while simultaneously enabling previously inaccessible separations. Graphene Oxide (GO) membranes enable a new materials platform for fine liquid filtration in harsh environments. These temperature stable, solvent resistant, and oxidizer tolerant membranes will accomplish nanofiltration (NF) separation of a range of feed streams. With immediate benefits in reducing cleaning time and downtime for dairy and food production and high impact for energy savings in pharmaceutical and chemical separations, materials innovation for membranes represents a large opportunity for energy and cost savings. GO is synthesized at near ambient temperatures with low-cost synthetic chemistry methods and thus is many orders of magnitude less expensive than graphene. This proposal focuses on further developing the graphene oxide material for the high value pharmaceutical and chemical streams in order to transition from heat-based or low-throughput distillation, evaporation, and chromatography methods towards the significantly lower cost and energy-efficient membrane alternative.

拟议的SBIR项目的广泛影响是在工业应用中开发基于氧化石墨烯的过滤膜，如制药和化工生产。 目前的聚合物膜不能满足特定的工业需求，并且不太可能通过渐进式创新来实现。另一方面，从蒸馏和蒸发转换为膜分离有可能将美国的能源消耗降低10%。 所提出的基于氧化石墨烯的材料是一种坚固的纳米材料，其能够在分子水平上分离流，同时承受化学分离的挑战性环境。成功实施将提高制药和化学品生产商的工艺强化和能源效率，同时实现以前无法实现的分离。 氧化石墨烯（GO）膜为恶劣环境中的精细液体过滤提供了新的材料平台。这些温度稳定、耐溶剂和耐氧化剂的膜将实现一系列进料流的纳滤（NF）分离。由于在减少乳制品和食品生产的清洁时间和停机时间方面具有直接的好处，并且对药物和化学分离的能源节约具有很大的影响，膜材料创新代表了能源和成本节约的巨大机会。GO在接近环境温度下用低成本合成化学方法合成，因此比石墨烯便宜许多数量级。 该提案的重点是进一步开发用于高价值制药和化学物流的氧化石墨烯材料，以便从基于热或低通量蒸馏，蒸发和色谱方法过渡到成本显著降低和节能的膜替代品。