SBIR Phase II: Robust Nanofiltration to Enable Challenging Chemical and Pharmaceutical Separations

SBIR 第二阶段：强大的纳滤技术可实现具有挑战性的化学和药物分离

• 批准号: 1831203
• 负责人: Shreya Dave
• 金额: $ 72.84万
• 依托单位: Via Separations, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2022-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831203&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Robust; Nanofiltration

This SBIR Phase II project focuses on advancing the domestic manufacturing capabilities for high-value nanomaterials for new membrane materials. Previously, the company has developed a novel membrane material with considerable economic, environmental, and nutritional impact in industrial process applications. Commercially available nanofiltration (NF) membrane systems employ polymer membranes, which have inherent chemical and thermal intolerance and are therefore difficult to clean or cannot be used in all separation streams. Meanwhile, 12% of US energy consumption is dedicated to thermal separations, a number that can be cut by a factor of 10 with appropriate physical separation technologies. This technology has applications across food & beverage processing, pharmaceutical production, semiconductor manufacturing, and chemical/petrochemical refining.Creating nanometer-scale features on large areas (tens of square meters) will enable technical opportunities for a multitude of products and applications. In this SBIR Phase II project, the company is conducting process development, pilot demonstration, and scale up efforts toward coating graphene oxide thin films for nanofiltration membrane separations applications. Today?s membrane processes are limited by the selectivity and durability of the nanofiltration membrane. Improved selectivity and operational conditions from the material platform enables improved downstream processes, and new product development. The technology is tolerant to elevated temperatures, extreme pH, organic and chlorinated solvents, and high levels of oxidizers. Transitioning from thermal separations to membrane separations saves 90% of the required energy. Meanwhile, payback time is 3 months when improving clean-in-place (CIP) protocol for existing NF processes. This is a game changer for the separations industry. Key separations of interest include desalting, whey concentration, sugar fractionation, fatty acid separation, nutraceutical extraction, pharmaceutical purification and black liquor concentration.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该SBIR II期项目的重点是推进新膜材料的高价值纳米材料的国内制造能力。此前，该公司开发了一种新型的膜材料，在工业过程应用中具有相当大的经济，环境和营养影响。市售的纳米滤过（NF）膜系统采用了具有固有的化学和热耐受性的聚合物膜，因此难以清洁或不能在所有分离流中使用。同时，美国12％的能源消耗专用于热分离，这一数字可以通过适当的物理分离技术削减10倍。该技术在食品和饮料加工，制药生产，半导体制造以及化学/石化炼油中都有应用。在大面积（数十平方米）上创建纳米尺度的特征将为多种产品和应用带来技术机会。在这个SBIR II阶段项目中，该公司正在进行过程开发，试点演示，并扩大为涂层氧化石墨烯薄膜的努力，以进行纳米滤膜分离应用。如今的膜过程受纳米滤膜的选择性和耐用性的限制。从材料平台上提高了选择性和操作条件，可以改善下游过程和新产品开发。该技术耐受性，极端pH值，有机和氯化溶剂以及高水平的氧化剂的耐受性。从热分离到膜分离的过渡可节省90％所需的能量。同时，在现有NF流程改进就地（CIP）协议时，回报时间为3个月。这是分离行业的游戏规则改变者。关键的关键分离包括脱盐，乳清浓度，糖分离，脂肪酸分离，营养萃取，药物纯化和黑酒浓度。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛的影响审查标准来通过评估来通过评估来支持的。