MRI: Acquisition of a Micro-CT system for 3D tissue and materials structure analysis

MRI：获取用于 3D 组织和材料结构分析的 Micro-CT 系统

• 批准号: 1725656
• 负责人: Daniel Engebretson
• 金额: $ 26.27万
• 依托单位: University of South Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1725656&HistoricalAwards=false
• 关键词: MRI; Acquisition; Micro; CT; system

This research project involves acquiring a high-resolution, non-destructive 3-dimensional specimen micro-computed tomography (micro-CT) imaging instrument to study the structure of 3-dimensional biomaterials as well as animal and plant tissues. This state-of-the-art instrument is a state-wide resource available to all researchers across the South Dakota region. The acquired micro-CT significantly enhances the infrastructure and collaborative atmosphere in three research universities, namely the University of South Dakota, South Dakota State University, and South Dakota School of Mines and Technology, as well as the non-profit research organization, Sanford Research. This instrument enables an increased number of successful research projects and the training of future scientists and engineers. This instrument-acquisition project leverages the long-standing state-wide network, enabled by the NSF EPSCoR, the NSF REU, and the NIH IDeA Network of Biomedical Research Excellence programs, to attract new faculty researchers and to inspire young people in STEM studies and careers. The acquired instrumentation enables important studies expected to contribute to the fundamental understanding of the signaling pathways in determination of a variety of tissue development (e.g., bone, blood vessel, tumor and plant root system) and the relationships between the structure and function of materials and tissues. The specific projects enabled by the micro-CT instrument include: 1) Modulation of adult stem cell functions by innovative bone-matrix mimicking 3-dimensional scaffolds; 2) Imaging of novel antibacterial materials for bone repair; 3) Engineering of desensitizing and remineralizing scaffolds in the dentinal tubules of human teeth; 4) Study of the role of Notch signaling pathway in bone development and tumorigenesis; 5) Development of innovative 3D electrospun nanofibrous polymer/mineral composite scaffolds; 6) Identification of the role of miRNAs in soybean nodule development; and 7) Biomechanical investigation of the effect of irradiation therapy on healthy and cancerous bone. Results from these studies form the foundation for the development of innovative biomaterials and new drugs. This award is funded by the Office of Assistant Director of Engineering.

本研究项目包括获取一台高分辨率、非破坏性的三维标本微计算机断层扫描（micro-CT）成像仪器，用于研究三维生物材料和动植物组织的结构。这种最先进的仪器是全州范围内的资源，可供南达科他州地区的所有研究人员使用。获得的micro-CT显著增强了三所研究型大学的基础设施和合作氛围，这三所大学分别是南达科他州大学、南达科他州立大学和南达科他州矿业与技术学院，以及非营利研究机构桑福德研究中心。该仪器使更多的成功研究项目和培训未来的科学家和工程师成为可能。该仪器收购项目利用由NSF EPSCoR， NSF REU和NIH IDeA生物医学研究卓越项目网络支持的长期全州网络，吸引新的教师研究人员并激励年轻人从事STEM研究和职业。获得的仪器使重要的研究有望有助于基本理解各种组织发育（如骨、血管、肿瘤和植物根系）的信号通路，以及材料和组织的结构和功能之间的关系。micro-CT仪器支持的具体项目包括：1)利用创新的骨基质模拟三维支架调节成体干细胞功能；2)骨修复新型抗菌材料的影像学研究；3)人牙本质小管脱敏再矿化支架工程；4) Notch信号通路在骨发育和肿瘤发生中的作用研究；5)新型3D电纺纳米纤维聚合物/矿物复合材料支架的开发；6) mirna在大豆根瘤发育中的作用鉴定；7)放射治疗对健康骨和癌变骨影响的生物力学研究。这些研究的结果为创新生物材料和新药的开发奠定了基础。该奖项由工程助理主任办公室资助。