MRI: Acquisition of a New Nuclear Magnetic Resonance (NMR) Instrument with Cryoprobe at Carnegie-Mellon University

MRI：卡内基梅隆大学购买了带有冷冻探针的新型核磁共振 (NMR) 仪器

• 批准号: 1726525
• 负责人: Roberto Gil
• 金额: $ 37.47万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726525&HistoricalAwards=false
• 关键词: MRI; Acquisition; New; Nuclear; Magnetic

This award is supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation Programs. Professor Roberto Gil from Carnegie Mellon University and colleagues are acquiring a 400 MHz NMR spectrometer equipped with cryoprobe. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the study molecular structure. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to many chemists who are carrying out frontier research. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics and biochemistry. This instrument is an integral part of teaching as well as research performed by graduate and undergraduate students via independent student research and traditional academic coursework. Industrial partners area also provided access to the instrumentation in the NMR facility.The award of the NMR spectrometer with a cryoprobe is aimed at enhancing research and education at all levels. It especially impacts studies of atom transfer radical polymerization (ATRP) and synthesis of protein polymers and biomaterials that have the potential for use in regenerative medicine, drug delivery and neural interfaces. The instrumement is also used for researching substances to aid in aleviating the opioid crisis in America as well as for preparing polymeric materials that bear main-group elements. In addition, the NMR spectrometer benefits exploration of solar fuel generation - making polymers and materials via the principles of molecular design. The spectrometer benefits characterization of hybrid inorganic-nucleic acid nanostructures, indicator dyes for biological imaging, atmospheric aerosols, and compressed cross-linked polymer gels.

该奖项由主要研究仪器(MRI)和化学研究仪器计划支持。卡内基梅隆大学的罗伯托·吉尔教授和他的同事们正在获取一台配备了冷冻探头的400 MHz核磁共振光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及对生物相关物种的研究。总的来说，核磁共振波谱是化学家研究分子结构的最有力的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于许多从事前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果对合成有机/无机化学、材料化学、法医学和生物化学产生了影响。该仪器是研究生和本科生通过独立的学生研究和传统的学术课程进行的教学和研究的组成部分。工业伙伴地区还提供了进入核磁共振设施的仪器。授予核磁共振光谱仪一个低温探头旨在加强各级的研究和教育。它尤其影响原子转移自由基聚合(ATRP)以及蛋白质聚合物和生物材料的合成，这些材料有可能用于再生医学、药物输送和神经接口。该仪器还用于研究有助于缓解美国阿片类药物危机的物质，以及制备含有主族元素的聚合物材料。此外，核磁共振光谱仪有助于通过分子设计原理探索制造太阳能燃料的聚合物和材料。该光谱仪有利于表征杂化的无机-核酸纳米结构、生物成像的指示剂染料、大气气溶胶和压缩的交联聚合物凝胶。

项目成果

Degradable Polymer Stars Based on Tannic Acid Cores by ATRP

• DOI: 10.3390/polym11050752
• 发表时间: 2019-05-01
• 期刊: POLYMERS
• 影响因子: 5
• 作者: Cuthbert, Julia;Yerneni, Saigopalakrishna S.;Matyjaszewski, Krzysztof
• 通讯作者: Matyjaszewski, Krzysztof

High-Throughput Screening and Automated Data-Driven Analysis of the Triplet Photophysical Properties of Structurally Diverse, Heteroleptic Iridium(III) Complexes

• DOI: 10.1021/jacs.0c12290
• 发表时间: 2021-01-07
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: DiLuzio, Stephen;Mdluli, Velabo;Bernhard, Stefan
• 通讯作者: Bernhard, Stefan

Transformation of gels via catalyst-free selective RAFT photoactivation

通过无催化剂选择性 RAFT 光活化实现凝胶转化

• DOI: 10.1039/c9py00213h
• 发表时间: 2019
• 期刊: Polymer Chemistry
• 影响因子: 4.6
• 作者: Shanmugam, Sivaprakash;Cuthbert, Julia;Flum, Jacob;Fantin, Marco;Boyer, Cyrille;Kowalewski, Tomasz;Matyjaszewski, Krzysztof
• 通讯作者: Matyjaszewski, Krzysztof

Iron-Catalyzed Atom Transfer Radical Polymerization of Semifluorinated Methacrylates

• DOI: 10.1021/acsmacrolett.9b00579
• 发表时间: 2019-09-01
• 期刊: ACS MACRO LETTERS
• 影响因子: 7.015
• 作者: Dadashi-Silab, Sajjad;Matyjaszewski, Krzysztof
• 通讯作者: Matyjaszewski, Krzysztof

Covalent conjugation of bioactive peptides to graphene oxide for biomedical applications

• DOI: 10.1039/c9bm00867e
• 发表时间: 2019-09-01
• 期刊: BIOMATERIALS SCIENCE
• 影响因子: 6.6
• 作者: Eckhart, Karoline E.;Holt, Brian D.;Sydlik, Stefanie A.
• 通讯作者: Sydlik, Stefanie A.