NRT-UtB: Training the Next Generation of Researchers in Engineering and Deciphering of Miniature Brain Machinery

NRT-UtB：培训下一代微型脑机工程和破译研究人员

• 批准号: 1735252
• 负责人: Martha Gillette
• 金额: $ 300万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1735252&HistoricalAwards=false
• 关键词: NRT; UtB; Training; Next; Generation

This National Science Foundation Research Traineeship award to the University of Illinois at Urbana-Champaign will address the next frontier in biotechnology: to engineer, and then decipher and harness, the living three-dimensional brain. The program will provide doctoral students with the skills and knowledge base to develop and utilize miniature brain machinery in an effort to understand and regulate brain activities. To achieve the goals of developing cross-disciplinary researchers, trainees will learn diverse fundamentals in biology, mathematics, engineering, and cognitive science, relevant to miniature brain machinery. The training grant anticipates providing a unique and comprehensive training opportunity for sixty (60) PhD students, including thirty four (34) funded trainees. Trainees will be recruited from neuroscience, cell and developmental biology, molecular and integrative physiology, chemistry, chemical and biomolecular engineering, bioengineering, electrical and computer engineering, and psychology. The training program will foster a culture of innovation and translational research, and will produce a new generation of scientists and engineers prepared to tackle major problems in brain studies that can improve the quality of human life.The research and training program will bridge two dominant, non-overlapping brain research paradigms: i) cognitive and behavioral studies, focused principally on understanding of adaptation, decision-making, psychology, and learning of an individual using bioimaging and computational tools vs. ii) cell and tissue studies, focused on activities of multiple neuronal cells by altering their internal and external microenvironments comprised of biomolecules, extracellular matrix, and external stimuli. The goal of this NRT training program is to unite these two dominant paradigms in brain science studies and bridge the expertise of cell and molecular biologists, physiologists, chemists, nano/micro technologists, and cognitive neuroscientists. This training program prepares students for studies that enable control over the networks producing behavior and thus to study causal relations. The overarching goal of the program is to provide students with an interdisciplinary curriculum grounded in problem-based learning and an immersive research experience that blends techniques from multiple disciplines. A second goal is to increase the participation of women, underrepresented minorities, and students with disabilities in neuroscience, life sciences, chemical sciences, and engineering fields. A third goal is to train students in communication skills with the public. Evaluative studies conducted throughout this research traineeship project will explore the dynamics and efficacy of interdisciplinary collaboration by students in this program. Project outcomes will be a demonstrated, evaluated model for transformative graduate training that is effective in developing broadly trained professionals. The NSF Research Traineeship (NRT) Program is designed to encourage the development and implementation of bold, new potentially transformative models for STEM graduate education training. The Traineeship Track is dedicated to effective training of STEM graduate students in high priority interdisciplinary research areas, through comprehensive traineeship models that are innovative, evidence-based, and aligned with changing workforce and research needs.

伊利诺伊大学厄巴纳-香槟分校获得的国家科学基金会研究培训奖将解决生物技术的下一个前沿问题：工程师，然后破译和利用活的三维大脑。该计划将为博士生提供技能和知识基础，以开发和利用微型大脑机器，以了解和调节大脑活动。为了实现发展跨学科研究人员的目标，学员将学习生物学，数学，工程学和认知科学的各种基础知识，与微型大脑机械有关。培训补助金预计将为六十（60）名博士生提供独特而全面的培训机会，其中包括三十四（34）名受资助的学员。学员将从神经科学，细胞和发育生物学，分子和综合生理学，化学，化学和生物分子工程，生物工程，电气和计算机工程，心理学。该培训计划将培养创新和转化研究的文化，并将培养新一代的科学家和工程师，准备解决大脑研究中的重大问题，以改善人类生活质量。该研究和培训计划将弥合两个主导的，不重叠的大脑研究范式：认知和行为研究，主要侧重于理解适应、决策、心理学，和使用生物成像和计算工具对个体的学习; ii）细胞和组织研究，通过改变由生物分子，细胞外基质，和外部刺激。该NRT培训计划的目标是将脑科学研究中的这两种主导范式结合起来，并将细胞和分子生物学家，生理学家，化学家，纳米/微技术专家和认知神经科学家的专业知识联系起来。该培训计划为学生准备研究，使控制网络产生的行为，从而研究因果关系。该计划的总体目标是为学生提供基于问题学习的跨学科课程和融合多学科技术的沉浸式研究体验。第二个目标是增加妇女、代表性不足的少数民族和残疾学生在神经科学、生命科学、化学科学和工程领域的参与。第三个目标是培养学生与公众沟通的技能。在整个研究实习项目中进行的评估研究将探索学生在该计划中跨学科合作的动态和有效性。项目成果将是一个经过验证和评估的转型研究生培训模式，有效地培养受过广泛培训的专业人员。NSF研究培训（NRT）计划旨在鼓励为STEM研究生教育培训开发和实施大胆的，新的潜在变革模式。培训课程致力于在高优先级的跨学科研究领域对STEM研究生进行有效培训，通过全面的培训模式，这些模式具有创新性，以证据为基础，并与不断变化的劳动力和研究需求保持一致。

项目成果

Morphometric analysis of sperm used for IVP by three different separation methods with spatial light interference microscopy

使用空间光干涉显微镜通过三种不同的分离方法对用于 IVP 的精子进行形态测量

• DOI: 10.1080/19396368.2019.1701139
• 发表时间: 2020
• 期刊: Systems Biology in Reproductive Medicine
• 影响因子: 2.4
• 作者: Rubessa, Marcello;Kandel, Mikhail E.;Schreiber, Sierra;Meyers, Sasha;Beck, Douglas H.;Popescu, Gabriel;Wheeler, Matthew B.
• 通讯作者: Wheeler, Matthew B.

Droplet Microfluidics with MALDI-MS Detection: The Effects of Oil Phases in GABA Analysis.

• DOI: 10.1021/acsmeasuresciau.1c00017
• 发表时间: 2021-12-15
• 期刊: ACS measurement science au
• 作者: Bell SE;Park I;Rubakhin SS;Bashir R;Vlasov Y;Sweedler JV
• 通讯作者: Sweedler JV

Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers

• DOI: 10.1038/s41598-020-70148-1
• 发表时间: 2020-08-07
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Sinclair, Whitney E.;Chang, Huei-Huei;Leckband, Deborah E.
• 通讯作者: Leckband, Deborah E.

Wolf phase tomography (WPT) of transparent structures using partially coherent illumination

• DOI: 10.1038/s41377-020-00379-4
• 发表时间: 2020-08-19
• 期刊: LIGHT-SCIENCE & APPLICATIONS
• 影响因子: 19.4
• 作者: Chen, Xi;Kandel, Mikhail E.;Popescu, Gabriel
• 通讯作者: Popescu, Gabriel

Network science characteristics of brain-derived neuronal cultures deciphered from quantitative phase imaging data

• DOI: 10.1038/s41598-020-72013-7
• 发表时间: 2020-09
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: Chenzhong Yin;Xiongye Xiao;Valeriu Balaban;M. Kandel;Y. J. Lee;G. Popescu;P. Bogdan