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NRT-UtB: Neurophotonics

NRT-UtB：神经光子学

基本信息

批准号：
1633516
负责人：
Thomas Bifano
金额：
$ 292.88万
依托单位：
Trustees of Boston University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1633516&HistoricalAwards=false
关键词：
NRT UtB Neurophotonics

项目摘要

This National Science Foundation Research Traineeship (NRT) award to Boston University will train scientists and engineers in the emerging interdisciplinary field of neurophotonics - the use of light-based tools to study brain function at the cellular scale. Understanding how neural activities and circuits drive human computation, behavior, and psychology is motivated by a critical societal need to address brain diseases that involve disruptions or deterioration of neural circuitry - including Alzheimer's, traumatic brain injury, Parkinson's, cerebral palsy and multiple sclerosis. Recent scientific discoveries and powerful new tools in brain research have inspired broad student interest in career paths focused on understanding brain structure and function, as well as new industrial and academic career opportunities. Neurophotonics is among the most rapidly evolving research frontiers in brain science because it allows researchers to monitor and influence neuron activity and neural circuits at their most fundamental level. A prominent neurophotonic technique is optogenetics, through which communication signals from neurons are precisely monitored, activated, or inhibited using light. This project will support training for eighty (80) PhD students, including twenty (20) funded trainees, across the disciplines of neuroscience, biomedical engineering and photonics.Trainees will become versed in the biology of neural function and the development of optical instruments, photo-excitable materials, and imaging techniques to sense and affect neural circuits. NRT trainees will graduate having attended a hands-on neurophotonics technology boot camp, participated in multiple laboratory research rotations, completed a four-course core curriculum, conducted challenging doctoral research in a neurophotonics laboratory, and written a neurophotonics-themed dissertation co-mentored by NRT faculty. The traineeship project will emphasize immersive experiential learning activities and peer-to-peer learning, two educational approaches that have been shown to reinforce learning while simultaneously improving outcomes for STEM trainees, especially underrepresented minorities. Interwoven with educational activities will be a professional preparation program that supports trainee career goals, develops communication skills, and builds professional networks. Trainee learning objectives will focus on identifying important research problems in neurophotonics, applying light-based methods to measure and control neural circuits, working on team-oriented projects, and communicating effectively.The NSF Research Traineeship (NRT) Program is designed to encourage the development and implementation of bold, new potentially transformative models for STEM graduate education training. The Traineeship Track is dedicated to effective training of STEM graduate students in high priority interdisciplinary research areas, through the comprehensive traineeship model that is innovative, evidence-based, and aligned with changing workforce and research needs.

美国国家科学基金会授予波士顿大学的研究实习生 (NRT) 奖将培训神经光子学这一新兴跨学科领域的科学家和工程师，即使用基于光的工具在细胞尺度上研究大脑功能。了解神经活动和回路如何驱动人类计算、行为和心理的动机是解决涉及神经回路破坏或退化的脑部疾病（包括阿尔茨海默病、创伤性脑损伤、帕金森病、脑瘫和多发性硬化症）的关键社会需求。大脑研究领域的最新科学发现和强大的新工具激发了学生对以了解大脑结构和功能为重点的职业道路以及新的工业和学术职业机会的广泛兴趣。神经光子学是脑科学中发展最快的研究前沿之一，因为它允许研究人员在最基本的层面上监测和影响神经元活动和神经回路。一种著名的神经光子技术是光遗传学，通过该技术，可以利用光精确监测、激活或抑制来自神经元的通信信号。该项目将支持对八十 (80) 名博士生进行培训，其中包括二十 (20) 名受资助的受训人员，涵盖神经科学、生物医学工程和光子学等学科。受训人员将精通神经功能生物学以及光学仪器、光激发材料和成像技术的开发，以感知和影响神经回路。 NRT 学员毕业时将参加神经光子学技术实践训练营、参加多个实验室研究轮转、完成四门课程的核心课程、在神经光子学实验室进行具有挑战性的博士研究，并撰写由 NRT 教师共同指导的神经光子学主题论文。培训项目将强调沉浸式体验式学习活动和同伴学习，这两种教育方法已被证明可以强化学习，同时改善 STEM 学员（尤其是代表性不足的少数群体）的成果。与教育活动交织在一起的专业准备计划将支持学员的职业目标、培养沟通技巧并建立专业网络。学员学习目标将侧重于识别神经光子学中的重要研究问题、应用基于光的方法来测量和控制神经回路、开展以团队为导向的项目以及有效沟通。 NSF 研究培训 (NRT) 计划旨在鼓励为 STEM 研究生教育培训开发和实施大胆的、具有潜在变革性的新模型。培训课程致力于通过创新、循证且符合不断变化的劳动力和研究需求的综合培训模式，对高度优先的跨学科研究领域的 STEM 研究生进行有效培训。

项目成果

期刊论文数量（57）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters.

DOI：
10.1117/1.nph.7.4.045005
发表时间：
2020-10
期刊：
Neurophotonics
影响因子：
5.3
作者：
Yang J;Chen IA;Chang S;Tang J;Lee B;Kılıç K;Sunil S;Wang H;Varadarajan D;Magnain C;Chen SC;Costantini I;Pavone F;Fischl B;Boas DA
通讯作者：
Boas DA

Exploring the human cerebral cortex using confocal microscopy

使用共聚焦显微镜探索人类大脑皮层