Meeting: Inside the black box: the mitochondrial basis of life-history variation and animal performance: January 3-7, 2018: San Francisco, CA

会议：黑匣子内部：生活史变异和动物表现的线粒体基础：2018 年 1 月 3 日至 7 日：加利福尼亚州旧金山

• 批准号: 1738378
• 负责人: Wendy Hood
• 金额: $ 1.48万
• 依托单位: Auburn University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1738378&HistoricalAwards=false
• 关键词: Meeting; Inside; black; box; mitochondrial

Mitochondria play a critical role in determining animal performance. Mitochondria produce cellular energy molecules that fuel nearly all organismal processes, but also are responsible for the production of reactive oxygen species - and in turn oxidative stress - an important contributor to senescence. As a result, variation in mitochondrial properties between individuals can predict differences in growth, reproduction, and rate of aging. While integrative measures of mitochondrial function are beginning to provide new insight, the theory and methods associated with these approaches are not widespread in the research community. To address this need, a symposium will be held at the national meeting of the Society for Integrative and Comparative Biology, Jan 3-7, 2018 in San Francisco, CA. The symposium is designed to aid networking among investigators and expand the appreciation of the ecological and evolutionary effects of mitochondrial function to a wider community. The symposium will include a wide diversity of scientists, including students and postdoctoral fellows. The invited speakers will be made up of an equal number of men and women ranging from the level of post-doc, through to assistant, associate, and full professors. Complementary oral and poster sessions will enable graduate and undergraduate students to participate in the symposium. All presenters in the main symposium and companion sessions will submit an article associated with their talk that will be published in a special issue of Integrative and Comparative Biology. Through this publication, the ideas presented in the main symposium will be disseminated to a larger audience and cumulatively provide a basis for future studies of mitochondrial function and life history variation.Mitochondria play a critical role in determining organismal performance through their production of ATP. But, they also generate reactive oxygen species - and in turn oxidative stress - an important contributor to senescence. As a result, variation in mitochondrial properties between individuals can predict differences in organismal maintenance, growth, and reproduction. Researchers have begun bringing measurements of mitochondrial function common to biomedical research to ecological and evolutionary studies. In addition, researchers have begun to evaluate the genetic basis and in turn heredity of mitochondrial performance via the intricate interactions between mitochondria and nuclear genes coding for the mitochondrial proteins. The integration of these measures with oxidative stress, metabolic rate, and other variables related to energetic capacity and efficiency have begun to shed new light on the processes that contribute to organismal performance. Thus, it is an opportune moment to bring investigators together in an organized symposium, to present their research and assess the way forward in this research. The symposium will introduce new investigators to this field, provide a forum for networking, and promote expansion of expertise in the ecological and evolutionary effects of mitochondrial function.

线粒体在决定动物性能方面起着至关重要的作用。线粒体产生细胞能量分子，为几乎所有的生物过程提供燃料，但也负责产生活性氧物种--进而产生氧化应激--这是导致衰老的重要因素。因此，个体之间线粒体特性的差异可以预测生长、繁殖和衰老速度的差异。虽然线粒体功能的综合测量开始提供新的见解，但与这些方法相关的理论和方法在研究界并不广泛。为了满足这一需求，将于2018年1月3日至7日在加利福尼亚州旧金山举行的综合与比较生物学学会全国会议上举行研讨会。该研讨会旨在帮助研究人员之间建立联系，并将对线粒体功能的生态和进化影响的认识扩大到更广泛的社区。研讨会将包括各种各样的科学家，包括学生和博士后研究员。被邀请的演讲者将由同等数量的男性和女性组成，从博士后水平到助理、副教授和正教授。互为补充的口头和海报会议将使研究生和本科生能够参加研讨会。所有在主要研讨会和配套会议上的演讲者将提交一篇与他们的演讲相关的文章，这篇文章将发表在综合与比较生物学的一期特刊上。通过这本出版物，在主要研讨会上提出的想法将被传播给更多的受众，并累积地为未来对线粒体功能和生活史变异的研究提供基础。线粒体通过产生ATP在决定生物性能方面发挥着关键作用。但是，它们也会产生活性氧物种--进而产生氧化应激--这是导致衰老的重要因素。因此，个体之间线粒体属性的差异可以预测生物维持、生长和繁殖的差异。研究人员已经开始将生物医学研究中常见的线粒体功能测量方法引入生态和进化研究。此外，研究人员已经开始通过线粒体和编码线粒体蛋白质的核基因之间复杂的相互作用来评估线粒体性能的遗传基础和遗传。这些措施与氧化应激、代谢率和其他与能量能力和效率相关的变量的整合，已经开始为促进生物表现的过程提供新的线索。因此，现在是将研究人员聚集在一个有组织的研讨会上，介绍他们的研究并评估这项研究的前进方向的好时机。研讨会将向这一领域引入新的研究人员，提供一个联网的论坛，并促进在线粒体功能的生态和进化效应方面的专业知识的扩展。

项目成果

Life History Trade-offs within the Context of Mitochondrial Hormesis

• DOI: 10.1093/icb/icy073
• 发表时间: 2018-09-01
• 期刊: INTEGRATIVE AND COMPARATIVE BIOLOGY
• 影响因子: 2.6
• 作者: Hood, W. R.;Zhang, Y.;Kavazis, A. N.
• 通讯作者: Kavazis, A. N.

Beyond the Powerhouse: Integrating Mitonuclear Evolution, Physiology, and Theory in Comparative Biology

超越动力源：在比较生物学中整合线粒体核进化、生理学和理论

• DOI: 10.1093/icb/icz132
• 发表时间: 2019
• 期刊: Integrative and Comparative Biology
• 影响因子: 2.6
• 作者: Havird, Justin C.;Weaver, Ryan J.;Milani, Liliana;Ghiselli, Fabrizio;Greenway, Ryan;Ramsey, Adam J.;Jimenez, Ana G.;Dowling, Damian K.;Hood, Wendy R.;Montooth, Kristi L.
• 通讯作者: Montooth, Kristi L.