Meeting: Inside the black box: the mitochondrial basis of life-history variation and animal performance: January 3-7, 2018: San Francisco, CA

线粒体在决定动物生产性能中起着关键作用。线粒体产生细胞能量分子，为几乎所有的生物过程提供燃料，但也负责产生活性氧，进而产生氧化应激，这是导致衰老的重要因素。因此，个体之间线粒体特性的差异可以预测生长、繁殖和衰老速度的差异。虽然线粒体功能的综合测量开始提供新的见解，但与这些方法相关的理论和方法在研究界并不普遍。为了满足这一需求，将于2018年1月3日至7日在加州旧金山举行的综合与比较生物学学会全国会议上举行一次研讨会。该研讨会旨在帮助研究人员建立网络，并将线粒体功能的生态和进化影响扩大到更广泛的社区。研讨会将包括各种各样的科学家，包括学生和博士后研究员。受邀的演讲者将由同等数量的男性和女性组成，范围从博士后到助理、副教授和正教授。补充口头和海报会议将使研究生和本科生参加研讨会。所有的主讲人将提交一篇与他们的演讲相关的文章，发表在《综合与比较生物学》的特刊上。通过这次出版，在主要研讨会上提出的想法将被传播给更多的受众，并逐渐为未来线粒体功能和生活史变异的研究提供基础。线粒体通过产生ATP在决定机体性能方面起着关键作用。但是，它们也会产生活性氧，进而产生氧化应激，这是导致衰老的重要因素。因此，个体间线粒体特性的差异可以预测机体维持、生长和繁殖方面的差异。研究人员已经开始将生物医学研究中常见的线粒体功能测量方法引入到生态和进化研究中。此外，研究人员已经开始通过线粒体和编码线粒体蛋白的核基因之间复杂的相互作用来评估线粒体性能的遗传基础和遗传。将这些测量与氧化应激、代谢率和其他与能量能力和效率相关的变量相结合，已经开始揭示有助于机体性能的过程。因此，这是一个将研究人员聚集在一起的有组织的研讨会，展示他们的研究并评估这项研究的前进方向的时机。本次研讨会将介绍该领域的新研究者，提供一个网络论坛，并促进线粒体功能的生态和进化影响方面的专业知识的扩展。

Mitochondria play a critical role in determining animal performance. Mitochondria produce cellular energy molecules that fuel nearly all organismal processes, but also are responsible for the production of reactive oxygen species - and in turn oxidative stress - an important contributor to senescence. As a result, variation in mitochondrial properties between individuals can predict differences in growth, reproduction, and rate of aging. While integrative measures of mitochondrial function are beginning to provide new insight, the theory and methods associated with these approaches are not widespread in the research community. To address this need, a symposium will be held at the national meeting of the Society for Integrative and Comparative Biology, Jan 3-7, 2018 in San Francisco, CA. The symposium is designed to aid networking among investigators and expand the appreciation of the ecological and evolutionary effects of mitochondrial function to a wider community. The symposium will include a wide diversity of scientists, including students and postdoctoral fellows. The invited speakers will be made up of an equal number of men and women ranging from the level of post-doc, through to assistant, associate, and full professors. Complementary oral and poster sessions will enable graduate and undergraduate students to participate in the symposium. All presenters in the main symposium and companion sessions will submit an article associated with their talk that will be published in a special issue of Integrative and Comparative Biology. Through this publication, the ideas presented in the main symposium will be disseminated to a larger audience and cumulatively provide a basis for future studies of mitochondrial function and life history variation.Mitochondria play a critical role in determining organismal performance through their production of ATP. But, they also generate reactive oxygen species - and in turn oxidative stress - an important contributor to senescence. As a result, variation in mitochondrial properties between individuals can predict differences in organismal maintenance, growth, and reproduction. Researchers have begun bringing measurements of mitochondrial function common to biomedical research to ecological and evolutionary studies. In addition, researchers have begun to evaluate the genetic basis and in turn heredity of mitochondrial performance via the intricate interactions between mitochondria and nuclear genes coding for the mitochondrial proteins. The integration of these measures with oxidative stress, metabolic rate, and other variables related to energetic capacity and efficiency have begun to shed new light on the processes that contribute to organismal performance. Thus, it is an opportune moment to bring investigators together in an organized symposium, to present their research and assess the way forward in this research. The symposium will introduce new investigators to this field, provide a forum for networking, and promote expansion of expertise in the ecological and evolutionary effects of mitochondrial function.