Analysing and modelling molecular rate variation among nuclear and mitochondrial genomes

分析和建模核和线粒体基因组之间的分子速率变化

• 批准号: DP0878014
• 负责人: Prof Simon Ho
• 金额: $ 16.49万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878014
• 关键词: Analysing; modelling; molecular; rate; variation

My research will have important practical benefits for bioinformaticians and evolutionary biologists, because existing analytical methods will be rigorously tested and new tools will be developed. Australia has a comparatively high concentration of researchers in this field, so my research will foster domestic collaboration and import international expertise. The research will provide important insights into the rates and patterns of genetic changes associated with domestication, and into variation in evolutionary rates among the primate ancestors of humans. In addition to developing new software, which will be made publicly available, I will develop new evolutionary models to supplement existing software packages.

我的研究将对生物信息学家和进化生物学家有重要的实际好处，因为现有的分析方法将得到严格的测试，新的工具将被开发。澳大利亚在这一领域的研究人员相对集中，因此我的研究将促进国内合作并引进国际专业知识。这项研究将为了解与驯化相关的基因变化的速度和模式，以及人类灵长类祖先进化速度的变异提供重要的见解。除了开发将公开提供的新软件外，我还将开发新的进化模型，以补充现有的软件包。