I-Corps: Nipple regeneration for breast cancer survivors

I-Corps:乳腺癌幸存者的乳头再生

基本信息

  • 批准号:
    1743950
  • 负责人:
  • 金额:
    $ 5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-06-15 至 2018-05-31
  • 项目状态:
    已结题

项目摘要

The broader impact/commercial potential of this I-Corps project is the development of a process technology that provides patients with a naturally pigmented donor skin scaffold (allograft) for recovery from surgeries, burns, and other procedures that require tissue regeneration. The availability of a natural scaffold helps improve patient physiological outcomes, and the use of similar pigmentation can improve natural integration with the recipient's existing skin, easing their emotional recovery and self-image. There is a growing demand for such engineered allografts in surgeries, including breast reconstruction. The incidence of breast cancer diagnosis has been increasing rapidly in the united states. Furthermore, the last few decades have seen an increasing trend for women to undergo a double mastectomy for preventative measures, even if breast cancer was only detected in one breast. Such procedures require complete reconstruction of both breasts. In 2015, there were 176,308 breast reconstructions and this number is expected to continue rising. This process technology will help meet some of this demand by improving the production of scaffolds, and may lead to new methods by which individuals planning surgeries can have their own tissue processed and reused in their procedures (autograft).This I-Corps project will develop a scaffold for nipple regeneration derived from human nipple areolar complex tissue. Currently, the best option for nipple reconstruction required in breast reconstruction is cutting and suturing the skin on the breast to create a scar mound with a subsequent tattoo for desired pigmentation that recreates the appearance of a nipple. Unfortunately, this method results in nipple flattening due to retraction forces of the underlying tissue and contraction of scar tissue. Instead of just recreating the appearance of a nipple, like current reconstruction methods, our engineering process technology allows the patient to have a scaffold assist in the regeneration of a nipple made from her own cells. Portions of the scaffold processing we are developing have been demonstrated in a laboratory setting. Advantages of this technology include improved cell proliferation, differentiation, and migration when the scaffold is repopulated with cells from the patient. It is highly desirable to maintain native tissue composition when engineering tissue scaffolds for regenerative medicine applications, and recent studies have demonstrated that superior function and complex tissue formation occurred when such scaffolds were derived from site-specific homologous tissues.
该 I-Corps 项目更广泛的影响/商业潜力是开发一种工艺技术,为患者提供天然色素的供体皮肤支架(同种异体移植物),用于从手术、烧伤和其他需要组织再生的手术中恢复。 天然支架的可用性有助于改善患者的生理结果,并且使用类似的色素沉着可以改善与接受者现有皮肤的自然融合,从而缓解他们的情绪恢复和自我形象。 外科手术(包括乳房重建)对此类工程同种异体移植物的需求不断增长。在美国,乳腺癌诊断的发生率一直在迅速增加。此外,在过去的几十年里,女性接受双侧乳房切除术作为预防措施的趋势不断增加,即使仅在一侧乳房中检测到乳腺癌。此类手术需要完全重建两个乳房。 2015年,共有176,308例乳房再造手术,预计这一数字将继续上升。该工艺技术将通过改进支架的生产来帮助满足部分需求,并可能带来新的方法,计划手术的个人可以在其手术中处理和重复使用自己的组织(自体移植)。该 I-Corps 项目将开发一种源自人类乳头乳晕复杂组织的乳头再生支架。目前,乳房重建所需的乳头重建的最佳选择是切割和缝合乳房上的皮肤,以形成疤痕丘,随后进行纹身,以实现所需的色素沉着,从而重现乳头的外观。 不幸的是,这种方法会由于下面组织的牵拉力和疤痕组织的收缩而导致乳头变平。我们的工程工艺技术不像目前的重建方法那样仅仅重建乳头的外观,而是允许患者使用支架来帮助患者用自己的细胞再生乳头。我们正在开发的部分支架加工已在实验室环境中得到证实。 该技术的优点包括当支架上重新填充来自患者的细胞时,细胞增殖、分化和迁移得到改善。当设计用于再生医学应用的组织支架时,非常希望保持天然组织成分,并且最近的研究表明,当此类支架源自位点特异性同源组织时,会发生优异的功能和复杂的组织形成。

项目成果

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Cory Hallam其他文献

SARS-CoV-2 recombinant spike ferritin nanoparticle vaccine adjuvanted with Army Liposome Formulation containing monophosphoryl lipid A and QS-21: a phase 1, randomised, double-blind, placebo-controlled, first-in-human clinical trial.
SARS-CoV-2 重组刺突铁蛋白纳米颗粒疫苗辅以含有单磷酰脂质 A 和 QS-21 的 Army 脂质体制剂:一项 1 期、随机、双盲、安慰剂对照、首次人体临床试验。
  • DOI:
    10.1016/s2666-5247(23)00410-x
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Brittany L Ober Shepherd;Paul T Scott;Jack N Hutter;Christine Lee;Melanie D McCauley;Ivelese Guzman;Christopher Bryant;Sarah McGuire;Jessie Kennedy;Wei;Agnes Hajduczki;T. Mdluli;Anais Valencia;M. Amare;G. Matyas;M. Rao;M. Rolland;J. Mascola;S. D. De Rosa;M. McElrath;David C. Montefiori;Leonid Serebryannyy;Adrian B McDermott;S. Peel;Natalie D. Collins;M. Joyce;M. Robb;Nelson L. Michael;S. Vasan;K. Modjarrad;Beza Gebrehana;Melissa E. Greenleaf;M. Hamer;Nathan K Jansen;Xiaotang Jing;Jael Kagai;Kamila Kourbanova;Michael A Koren;Monica L Martin;K. Wuertz;J. Regules;Aaron D Sanborn;David Wallace;Lei Zhu;Gregory D. Gromowski;Courtney Corbitt;Janice M Darden;V. Dussupt;Emily Golub;Jarrett A. Headley;Umair M Jarral;Jocelyn King;S. Krebs;Jenny Lay;Regina Lilly;Jennifer Lynch;Elizabeth J. Martinez;Sandra V. Mayer;Samantha McGeehon;Hyunna Lee;S. Schech;Mekdi Tadesse;P. Thomas;Yahel Romem;Erifile Zografos;Bob C Lin;S. Narpala;Lingshu Wang;N. Doria;Robin Carroll;Amanda Eaton;Emily D Badraslioglu;Jason M Koontz;Ugo E Nwaeze;Peter Dawson;Alexander J Noll;Christine M. Orndahl;Amy Bray;Ricardo Carrion;Jean Patterson;Viraj Kulkarni;Cory Hallam;Olga Gonzalez;M. Gazi
  • 通讯作者:
    M. Gazi

Cory Hallam的其他文献

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{{ truncateString('Cory Hallam', 18)}}的其他基金

University of Texas at San Antonio - Center for Innovation Technology Entrepreneurship Innovation Corps Sites Program
德克萨斯大学圣安东尼奥分校 - 创新技术创业中心创新军团站点计划
  • 批准号:
    1347393
  • 财政年份:
    2014
  • 资助金额:
    $ 5万
  • 项目类别:
    Standard Grant

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  • 批准号:
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  • 批准号:
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