The impact of biomimetic nipple on infant feeding function

仿生奶嘴对婴儿喂养功能的影响

• 批准号: 10671740
• 负责人: Christopher Mayerl
• 金额: $ 23.75万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671740
• 关键词: 3-Dimensional; Address; Anatomy; Animal Model; Automobile Driving; Behavior; Biomechanics; Biomimetics; Bolus Infusion; Brain Stem; Breast; Child; Chronic; Complex; Cranial Nerves; Data; Deglutition; Deglutition Disorders; Development; Discipline of Nursing; Electromyography; Environment; Ethics; Evidence based intervention; Exhibits; Faculty; Failure; Family suidae; Feedback; Food; Foundations; Funding; Generations; Goals; Hospitalization; Human; Infant; Intervention; Liquid substance; Measures; Mentors; Milk; Modeling; Motor; Motor output; Muscle; Muscle function; Musculoskeletal; Musculoskeletal System; Nature; Neuronal Plasticity; Nipples; Oropharyngeal; Outcomes Research; Output; Patients; Performance; Periodicity; Physiological; Physiology; Premature Infant; Productivity; Property; Radiation; Research; Resolution; Safety; Sensory; Speed; Suction; System; Testing; Translating; Variant; Viscosity; base; career; design; experience; experimental study; feeding; genioglossus muscle; improved; insight; kinematics; neonate; neural; neuromuscular; novel; premature; pressure; programs; response; sensory input; temporal measurement; therapy design; therapy development

Infant feeding is a complex behavior that requires the ability to both acquire milk, as well as transport and swallow it. Preterm infants often exhibit a decreased ability to generate suction pressure to acquire milk, and experience challenges transporting and swallowing milk. Understanding the mechanisms behind these challenges is difficult due to the complexity of infant feeding as well as the fragile nature of preterm infants. Feeding is controlled by multiple cranial nerves and over 25 muscles, yet we know little of how those muscles function due to the ethical and practical restrictions of acquiring data on human infants. Clinicians cannot control for the degree of prematurity in their patients, cannot measure muscle function accurately or precisely, and are limited in the temporal resolution of their data, due to radiation from videofluoroscopic swallowing studies. The objective of this proposal is to use a validated animal model to acquire controlled, high resolution data to study how term and preterm infants respond to interventions to improve feeding performance during feeding. This research will combine bi-planar (3D) high speed (100 fps) videofluoroscopy with chronic indwelling fine-wire electromyography to measure how muscles drive the kinematics, swallow safety, and fluid dynamics of term and preterm infant feeding. The central hypothesis is that term infants will show higher levels of pressure generation and ability to transport viscous fluids, but that the plastic neural system of preterm infants will enable them to exhibit a greater response to increases in pressure generation requirements and increases in viscosity. First, I will measure how the musculoskeletal system responds to changes in pressure generation requirements to acquire food in term and preterm infant pigs (SA1-K99), and then measure the neuromotor response to changes in viscosity in term and preterm infant pigs (SA2-K99). Following these, I will measure neuromotor function of term and preterm infants when feeding on a biomimetic nipple, compared to those currently available commercially (SA3-R00).This research will provide insight into the mechanisms driving feeding performance in infants and provide a foundation for developing interventions based off physiologic, rather than qualitative, indications of poor performance for patients with dysphagia. This is significant because it represents an important advance in the basic understanding of the mechanisms of infant feeding, and mechanisms of failure. As such these results will be the foundation for evidence-based interventions for neonate dysphagia. This project will directly advance my career goals to establish a federally funded research program grounded in understanding normal and pathophysiologic sensorimotor integration. NEOMED is an excellent environment for me to develop this research program, as there are an array of faculty within the department that conduct cutting edge research on musculoskeletal function, in addition to my research mentor, whom is an expert in the field of infant dysphagia.

婴儿喂养是一个复杂的行为，需要获得牛奶的能力，以及运输和 早产儿通常表现出产生抽吸压力以获取乳汁的能力下降， 在运输和吞咽牛奶方面遇到挑战。了解这些背后的机制 由于婴儿喂养的复杂性以及早产儿的脆弱性，挑战是困难的。 进食是由多个脑神经和超过25块肌肉控制的，但我们对这些肌肉是如何控制的知之甚少。 由于获取人类婴儿数据的道德和实际限制，功能。临床医生不能 无法控制患者的早产程度，无法准确或精确地测量肌肉功能， 并且由于视频荧光透视吞咽的辐射， 问题研究本提案的目的是使用经验证的动物模型来获得受控的高分辨率 研究足月儿和早产儿如何对干预措施作出反应，以改善喂养表现， 喂食本研究将联合收割机双平面（3D）高速（100 fps）视频透视与慢性 留置细线肌电图测量肌肉如何驱动运动学、吞咽安全性和流体 足月儿和早产儿喂养的动力学。中心假设是，足月婴儿将表现出更高的 水平的压力产生和运输粘性流体的能力，但塑料神经系统的 早产儿将使他们对压力产生需求的增加表现出更大的反应 并且粘度增加。首先，我将测量肌肉骨骼系统如何对 足月和早产仔猪获取食物的压力产生要求（SA 1-K99），然后 测量足月和早产小猪对粘度变化的神经运动反应（SA 2-K99）。 在此之后，我将测量足月儿和早产儿的神经运动功能， 仿生乳头，与目前市售的（SA 3-R 00）相比。这项研究将提供 深入了解驱动婴儿喂养表现的机制，并为开发 基于生理而非定性指征的干预措施， 吞咽困难这一点意义重大，因为它代表了对人类基本生活方式的理解的一个重要进展。 婴儿喂养机制和失败机制。因此，这些结果将成为 新生儿吞咽困难的循证干预措施。这个项目将直接推动我的职业目标， 建立一个联邦资助的研究计划，以了解正常和病理生理学 感觉运动整合NEOMED对我来说是一个很好的环境来发展这个研究项目， 系里有一批从事肌肉骨骼研究的教授 除了我的研究导师，他是婴儿吞咽困难领域的专家。