SBIR Phase I: e-CHEM: A fully-autonomous connected in-situ chemical sensor
SBIR 第一阶段:e-CHEM:完全自主连接的原位化学传感器
基本信息
- 批准号:1747293
- 负责人:
- 金额:$ 22.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-01-01 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this project addresses a great demand for in-situ chemical sensor technology with ability to (1) Measure with high resolution the environmental footprint of agricultural and urban development, and (2) Identify potential safety issues related to drinking water quality. High concentrations of nutrients (e.g. nitrate, nitrite, orthophosphate) in surface waters are the source of environmental, public health, and economic issues. Active monitoring of nutrient concentrations in surface waters such as estuaries, lakes and rivers is critical in assessing their health and implementing timely action to minimize ecosystem degradation. This SBIR project aims at developing a disruptive new type of highly miniaturized autonomous water quality chemical sensor, that can be operated remotely and autonomously, has minimal installation and maintenance requirements, is capable of performing thousands of measurements directly in-situ, in both reagent-based and reagent-less configuration, on a single battery charge. Applications that will greatly benefit from such sensors range from scientific research, to estimating nutrient loads, establishing discharge limits, predicting eutrophication conditions and demonstrating compliance with regulatory reporting requirements. Independently, the drinking water industry has its own requirements for autonomous chemical sensors for monitoring reservoirs and distribution networks, optimizing treatment processes and identifying tank nitrification issues early-on. This Small Business Innovation Research (SBIR) Phase I project aims to achieve the highest level of miniaturization and functionality attempted in a commercial water quality sensor. The core innovation of this proposed e-CHEM system is in the microfluidic chemical analysis module, combining a novel highly-efficient mixing mechanism to homogenize minute volumes of reagent with the fluid sample with a microfluidic implementation of dual reagent-based and reagent-less chemical measurement capability, the possibility of controlling relevant chemical reactions in-situ via precise on-chip temperature management, and finally the potential of overcoming the important hurdle of bio-fouling via novel surface nano-engineering. The parameters measured will include a selection from: ortho-phosphates, nitrites, nitrates, dissolved organic carbon, total and/or free chlorine, free ammonia, and pH. The system will include bidirectional wireless telemetry to enable automatic alert generation and data transmission to remote servers for visualization, analysis and interpretation. Target accuracy and response times are superior to traditional measurement techniques due to full process automation, elimination of sample degradation and transit times, reduction of human error, and automatic data centralization.
该项目更广泛的影响/商业潜力解决了对原位化学传感器技术的巨大需求,该技术能够(1)以高分辨率测量农业和城市发展的环境足迹,以及(2)识别与饮用水质量相关的潜在安全问题。地表沃茨中高浓度的营养物(如硝酸盐、亚硝酸盐、正磷酸盐)是环境、公共卫生和经济问题的根源。积极监测河口、湖泊和河流等地表沃茨的营养物浓度,对于评估其健康状况和及时采取行动尽量减少生态系统退化至关重要。该SBIR项目旨在开发一种具有颠覆性的新型高度小型化的自主水质化学传感器,该传感器可以远程和自主操作,具有最低的安装和维护要求,能够在单次电池充电时以基于试剂和无试剂的配置直接原位执行数千次测量。这些传感器的应用范围从科学研究到估计营养负荷,建立排放限制,预测富营养化状况以及证明符合监管报告要求。饮用水行业对用于监测水库和配水网络、优化处理过程和早期识别水箱硝化问题的自主化学传感器有自己的要求。这个小型企业创新研究(SBIR)第一阶段项目旨在实现商用水质传感器中最高水平的小型化和功能。该e-CHEM系统的核心创新在于微流控化学分析模块,结合了新型高效混合机制,将微量试剂与流体样品均质化,并具有基于试剂和无试剂的双重化学测量能力的微流控实现,通过精确的片上温度管理原位控制相关化学反应的可能性,最后,通过新的表面纳米工程克服生物污染的重要障碍的潜力。测量的参数将包括从以下中选择:正磷酸盐,亚硝酸盐,硝酸盐,溶解有机碳,总氯和/或游离氯,游离氨和pH值。该系统将包括双向无线遥测,以实现自动警报生成和数据传输到远程服务器,用于可视化,分析和解释。由于全过程自动化、消除样品降解和运输时间、减少人为错误以及自动数据集中,目标精度和响应时间上级传统测量技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joyce Wong其他文献
487 - Gastric Cancer in the Very Elderly: Benefit of Surgery and Systemic Treatment in a U.S. Population Study
- DOI:
10.1016/s0016-5085(17)34049-0 - 发表时间:
2017-04-01 - 期刊:
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- 作者:
Erin K. Greenleaf;Christopher S. Hollenbeak;Joyce Wong - 通讯作者:
Joyce Wong
Kiosk 4R-FC-05 - Pre-transplantation Right Ventricular Volumes Are Associated with All-cause Mortality After Lung Transplantation
4R-FC-05 自助服务终端 - 肺移植前右心室容积与肺移植后的全因死亡率相关
- DOI:
10.1016/j.jocmr.2024.100599 - 发表时间:
2024-03-01 - 期刊:
- 影响因子:6.100
- 作者:
Nikolaos Miaris;Georgia Sarri;Anne McDermott;Mandy McCurry;Alessandra Verzelloni Sef;Clarissa Borguezan Daros;John Dunning;Ulrich Stock;Felix Chua;Muhammad Usman;Chiara Bucciarelli-Ducci;Kavita Dave;Vicky Gerovasili;Nandor Marczin;Martin Carby;Anna Reed;Joyce Wong - 通讯作者:
Joyce Wong
Blood from Highly Allergic Donors Yields High-Affinity IgE Antibodies to Food and Non-food Allergens
高过敏供体的血液产生针对食物和非食物过敏原的高亲和力免疫球蛋白 E 抗体
- DOI:
10.1016/j.jaci.2021.12.537 - 发表时间:
2022-02-01 - 期刊:
- 影响因子:11.200
- 作者:
Derek Croote;Paige Creeks;Johanna Romero;Saba Sohail;Robert Sanchez Rodriguez;Joyce Wong - 通讯作者:
Joyce Wong
Tu1336 - Greater Lymph Node Retrieval Improves Survival in Node-Negative Resected Gastric Cancer
- DOI:
10.1016/s0016-5085(17)34293-2 - 发表时间:
2017-04-01 - 期刊:
- 影响因子:
- 作者:
Katelin Mirkin;Christopher S. Hollenbeak;Joyce Wong - 通讯作者:
Joyce Wong
DE-CMR and MPS for assessment of myocardial viability: to what extent do the two techniques agree?
- DOI:
10.1186/1532-429x-18-s1-p88 - 发表时间:
2016-01-27 - 期刊:
- 影响因子:
- 作者:
Thomas Alway;Charles Butcher;Evangelos Skondros;Richard Underwood;Joyce Wong - 通讯作者:
Joyce Wong
Joyce Wong的其他文献
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{{ truncateString('Joyce Wong', 18)}}的其他基金
SBIR Phase I: Automated In-Situ High-Resolution COVID-19 Wastewater-Based Epidemiology
SBIR 第一阶段:基于废水的自动化原位高分辨率 COVID-19 流行病学
- 批准号:
2041400 - 财政年份:2021
- 资助金额:
$ 22.5万 - 项目类别:
Standard Grant
SBIR Phase II: e-CHEM: A fully-autonomous connected in-situ chemical sensor
SBIR 第二阶段:e-CHEM:完全自主连接的原位化学传感器
- 批准号:
1927079 - 财政年份:2019
- 资助金额:
$ 22.5万 - 项目类别:
Standard Grant
I-Corps: Tissue-engineering vascular grafts using autologous cell sheets
I-Corps:使用自体细胞片进行组织工程血管移植
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1508331 - 财政年份:2015
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PESO: Engineered Platforms to Investigate Molecular Determinants of Tumor Metastasis to Targeted Niche Sites
PESO:研究肿瘤转移至目标位点的分子决定因素的工程平台
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1235316 - 财政年份:2012
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2011 Biomaterials & Tissue Engineering Gordon Research Conference
2011年生物材料
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1118459 - 财政年份:2011
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职业:生物医学工程细胞力学综合研究和教育项目
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9985338 - 财政年份:2000
- 资助金额:
$ 22.5万 - 项目类别:
Continuing Grant
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